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Biomedical subjects

N Sterescu

Publications and source records attributed to N Sterescu.

At least 37 records · Page 2Linked to original sources
PubMed1969

Non-steroidal antifertility agents affecting brain mechanisms.

Many non-steroidal agents prevent ovulation by acting on the nervous structures that control the secretion of gonadotrophins. Information on the neuroendocrine factors involved in the process of ovulation in mammals is presented in this paper and is then used as the background for explaining the mode of action of drugs which inhibit ovulation through an effect on the central nervous system. Such drugs are found among the following classes of compounds: CNS depressants, tranquillizers, cholinergic blocking agents, and adrenergic blocking agents. Although it is unlikely that any of the specific agents discussed in this paper will have clinical application, because of associated behavioural effects, the knowledge gained by studying the mode of action of these compounds indicates pathways to follow in the search for new anti-ovulatory drugs.

Acetylcholine↗
PubMedDate not supplied

Hormonal influences on RNA and DNA synthesis in developing rat brain.

In recent years, authors' interest was focussed on the role of hormones in the brain biochemical maturation during the early postnatal life. One-day-old rats were used in the investigation of the following hormones: thyroxine (T4), hydrocortisone, aldosterone and ACTH, in unique or repeated administration. Dynamics of cerebral RNA and DNA synthesis, a realiable indicator of central nervous system (CNS) maturation, was investigated. Authors' research led to the following conclusions: In infant rats, cerebral RNA and DNA synthesis exhibits a continuous increase, with a peak between 7 and 14 days after birth. Hydrocortisone induces a significant inhibition of cerebral RNA and DNA synthesis, more important in 7-day-old rats. In ACTH-treated newborn rats, RNA and DNA synthesis presents a high stimulation in 7- and 14-day-old rats. Aldosterone elicits an enhancement of brain nucleic acid synthesis, more marked in 7- and 14-day-old rats. Thyroxine administration induces a marked stimulation of cerebral RNA and DNA synthesis, greatest at 7 and 14 days after birth. The results confirm the important, even decisive, role of endocrine secretions during the early postnatal life, as far as the subsequent individual development is concerned.

Adrenocorticotropic Hormone↗