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Biomedical subjects

N Stasche

Publications and source records attributed to N Stasche.

29 records · Page 2Linked to original sources
PubMed1998

[Atypical localization of a small cell carcinoma in the paranasal sinus area--case report].

BACKGROUND: Malignant neoplasms of the paranasal sinuses are estimated at 3 to 5% of all head and neck malignant neoplasms. More than 50% of the cases are classified as squamous cell or anaplastic undifferentiated carcinomas. Extremely rare are small cell carcinomas localized in the paranasal sinuses. METHOD AND PATIENT: A 60-year-old male patient was seen in February 1996 in our ENT Department with unspecific pain on the left maxillary sinus and alveolar ridge. Anterior rhinoscopy revealed an extended tumor on the left nasal fossa; histopathological examination showed a small cell carcinoma. No other primary tumors or metastases were detected in extended staging. Due to the extended paranasal tumor as well as the histopathological findings, the patient was given induction chemotherapy followed by radiation therapy. RESULTS: To date (4/97), we achieved partial remission without any clinical complaints. CONCLUSIONS: The therapeutical result is comparable to other therapeutical regimens.

Aged↗
PubMed1997

[Icelandic moss lozenges in the prevention or treatment of oral mucosa irritation and dried out throat mucosa].

BACKGROUND: Icelandic Moss (Cetraria islandica) has been used to treat inflammation and dryness of the pharyngeal mucosa in the naturopathy for many years. It contains substances with protective and antiinflammatory effects for the oral mucosa. The necessary concentration of Icelandic Moss and its therapeutic effectiveness were analysed in this clinical study. METHODS: Sixty-one patients who recently underwent surgery of nasal septum were evaluated for this randomized study. These patients suffer especially from dryness and inflammation of the oral cavity due to breathing only through the mouth while the nose is permanently closed by a nasal package. Three groups of patients treated with three different concentrations of the active substance were compared, Coating, dryness, and inflammation of the mucosa, lymph nodes, tongue, the tolerance of the drug, and symptoms like hoarseness and sore throat were documented. The oral application was performed from the first to the fifth day after the operation. RESULTS: The treatment with Icelandic Moss caused a direct reduction of the observed pathological changes. There were no significant differences between the three test groups. A dose of 0.48 g per day (10 Isla-Moos lozenges per day) is a sufficient treatment. CONCLUSIONS: Icelandic Moss is an advisable therapeutic opportunity without interactions and side effects for the treatment of inflammation of the oral mucosa occurring after nasal surgery, after intubation, and for simple infections of the throat.

Adolescent↗
PubMed1997

[Problems in nasal CPAP management of the obstructive apnea patient--when is a tracheotomy indicated? A case report].

The use of nCPAP-ventilation has changed the rare indication for tracheotomy in patients with severe sleep apnoe syndrome. Only in cases where obstructive nasal and epipharyngeal processes are not resectable tracheotomy can be necessary. A case report shows one indication for such a surgical intervention. Increasing nasal obstruction usually can be treated successfully by operation.

Carcinoma↗
PubMed1996

[Surgically managed postoperative hemorrhage after tonsillectomy].

BACKGROUND: Bleeding after tonsillectomy is the most frequent and most dangerous complication. We compared the incidence of postoperative bleeding and secondary haemorrhage after tonsillectomy was examined using two methods of hemostasis (suture ligation versus electrocautery). METHODS: The study covered all tonsillectomies performed from 1992 to 1994. Data from about 2096 patients were assessed. RESULTS: The incidence of postoperative bleeding and hemorrhage was 5.4%. When suture ligation of vessels was used to obtain hemostasis during the operation it was evident that postoperative bleeding was rare but more difficult in comparison to the cases in which electrocautery was used alone. While primary bleeding for both methods was similar, secondary bleeding was more frequent after hemostasis achieved with electrocautery. DISCUSSION: Injury of the vessel by suture ligation is thought to be responsible for massive hemorrhage after tonsillectomy. Using electrocautery avoids this pathogenic mechanism. Since electrocautery of the tissue surrounding a vessel produces initial hemostasis, secondary bleeding is more frequent after the wound clot is opened. CONCLUSION: Use of electrocautery for hemostasis is justified since bleeding after primary hemostasis is usually easily managed.

Adolescent↗
PubMed1994

[Measuring vibrations by laser doppler vibrometry of the human tympanic membrane after stapes fixation].

At times preoperative diagnosis of otosclerosis can prove difficult. Even the objective measurement of the stapes reflex is not very conclusive in patients suffering from more severe hearing loss. Laser-Doppler vibrometry measures the velocity or amplitude of the tympanic membrane (umbo) vibrations. Laser-Doppler vibrometry has a sensitivity that is highly by the factor 10(4) than tympanometry. The herewith presented examinations show, that there is a correlation between the frequency patterns of the displacement amplitudes and experimentally simulated otosclerosis.

Fourier Analysis↗
PubMed1994

Middle ear transmission disorders--tympanic membrane vibration analysis by laser-Doppler-vibrometry.

Laser-Doppler-vibrometry is a useful method to measure vibrations of the tympanic membrane. It is suitable to objectively diagnose the middle ear. In comparison to tympanometry, laser-Doppler-vibrometry has greater sensitivity. Temporal bone specimens were specially prepared to simulate middle ear disorders like middle ear effusion, fixation of the malleus head, fixation of the stapes footplate and removal of the incus. A correlation between the displacement function of the umbo and the experimentally produced middle ear disorders could be demonstrated. For the first time it was possible to measure the vibration of the tympanic membrane by using a laser-Doppler-vibrometer in a healthy 25-year-old male.

Adult↗
PubMed1994

[The lidocaine test in tinnitus. Determination of its current status].

Intravenous administration of high doses of lidocaine has been used as a treatment modality for tinnitus. From 1991 to 1992 we treated 108 patients with high-dose lidocaine and had each patient complete a special tinnitus questionnaire. The effects of therapy were estimated on patients' subjective responses concerning loudness, suppression, stress relationships and mastering of tinnitus. These parameters were recorded before and after 5 days of lidocaine therapy. Quantification of tinnitus in acute and chronic disease showed significant temporary diminution of tinnitus in all patients. Complete alleviation of tinnitus was so impressive that personal attitudes concerning tinnitus were changed. These findings demonstrated that lidocaine was a useful strategy for significant relief of symptoms due to tinnitus.

Administration, Oral↗
PubMed1993

[Snoring and sleep apnea syndrome: surgical treatment and MESAM-IV controlled, postoperative results].

Approximately 20% of the population snore. Snoring is caused by a vibration of oropharyngeal soft tissues during air flow. The anatomical origin of snoring can be the soft palate with a hyperplastic uvula or the region of the base of tongue. An uvulopalatopharyngoplasty (UPPP) as a mode of surgical treatment is only appropriate in the first case. A patient can be considered to be suffering from sleep apnea syndrome if snoring is associated with a temporary complete obstruction of the upper airway with a subsequent decrease in oxygen saturation. In this case continuous positive airway pressure (CPAP) therapy can be beneficial; however, the role of surgery is confined to those operations providing unimpaired nasal air flow. Following extensive preoperative diagnostics, including sleep monitoring with the MESAM-IV-system, 68 patients with palatal snoring underwent surgery. 46 could be examined 6 to 8 months postoperatively: In 41 patients snoring disappeared completely or was reduced to a few occasional episodes. 5 patients continued to snore after the UPPP. These patients were obese at the time of surgery and a preoperative attempt to lose weight was only partially successful. Although we identified the soft palate as the probable cause of snoring by fiberoptic examination, especially the overweight patients bear the risk of additional narrow segments in the region of the base of the tongue. The appropriate weight loss is therefore a fundamental prerequisite for successful treatment. 5 patients with sleep apnea syndrome combined with nasal obstruction underwent septum, turbinate and sinus surgery to create unobstructed nasal airflow. The following CPAP treatment was of great benefit to them.(ABSTRACT TRUNCATED AT 250 WORDS)

Follow-Up Studies↗
PubMed1993

[Laser Doppler vibrometry of the tympanic membrane. Possibilities for objective middle ear diagnosis].

In the diagnosis of hearing disorders, the laser velocimeter can be used to advantage. In contrast to previously published studies on measurements at exposed middle and inner ear structures of the human temporal bone, we used a clinically more practical method to obtain results through the intact auditory meatus. We used a laser intensity of less than 1 mW. The measurements were performed in a room with unlimited sound transmission of frequencies between 0.5 and 8 kHz. The signals from the vibration of the tympanic membrane, obtained by this touch-free method, were analyzed by Fourier transform, showing only the fundamental oscillation but not the higher harmonics. Experimental data on middle ear effusions, obtained by fixation of the malleus head and by drilling the temporal bone, are presented.

Acoustic Stimulation↗