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Biomedical subjects

N Spencer

Publications and source records attributed to N Spencer.

At least 19 recordsLinked to original sources

Family and carer smoking control programmes for reducing children's exposure to environmental tobacco smoke.

BACKGROUND: Exposure to other people's cigarette smoke (environmental tobacco smoke, or ETS) is an important child health issue. OBJECTIVES: To determine the effectiveness of interventions aiming to reduce exposure of children to ETS. SEARCH STRATEGY: The Tobacco Addiction Group register of studies was searched. MEDLINE, EMBASE and four other health and psychology databases were searched electronically, bibliographies of retrieved primary studies were checked and specialists in the area consulted. SELECTION CRITERIA: Controlled trials with or without random allocation were included in this review if they addressed participants (parents and other family members, child care workers and teachers) involved with the care and education of infants and young children (aged 0-12 years). All mechanisms for reduction of children's environmental tobacco smoke exposure, and smoking prevention, cessation, and control programmes targeting these participants are included. These include smoke free policies and legislation, health promotion, social-behavioural therapies, technology, education and clinical interventions. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed studies and extracted data. Due to heterogeneity of methodologies and outcomes, no summary measures were possible and results were synthesised using narrative summaries. MAIN RESULTS: Nineteen studies met the inclusion criteria, one of which was subsequently excluded. Three interventions were targeted at populations or community settings, seven studies were conducted in the well child health care setting and eight in the ill child health care setting. Twelve of these studies are from North America. In 12 of the 18 studies there was reduction of ETS exposure for children in both intervention and comparison groups. In only four of the 18 studies was there a statistically significant intervention effect. Three of these successful studies employed intensive counselling interventions targeted to smoking parents. There is little difference between the well infant, child respiratory illness and other child illness settings as contexts for parental smoking cessation interventions. The fourth successful intervention was in the school setting targeting the ETS exposure of children from smoking fathers. REVIEWER'S CONCLUSIONS: Brief counselling interventions, successful in the adult health setting when coming from physicians, cannot be extrapolated to adults in the setting of child health. There is limited support for more intensive counselling interventions. There is no clear evidence for differences between the respiratory, non-respiratory ill child, well child and peripartum settings as contexts for reduction of children's ETS exposure.

Age Factors↗

The effects of work on the growth of Jordanian boys.

OBJECTIVE: To examine the effects of work on growth among boys aged 10-16 years in Jordan. STUDY DESIGN: Cross-sectional health survey comparing working and non-working boys. MAIN OUTCOMES: Height for age z-score; weight for age z-score. METHODS: One hundred and thirty-five working and 405 non-working boys aged 10-16 years were studied in the Jordanian areas of Irbid, Jarash and North Jordan Valley. The boys and their mothers were interviewed and data collected on work status, child's smoking status, and family socio-economic characteristics including per capita income, family size, maternal and paternal education, area of the house in square metres and expenditure on household durables. Height and weight were obtained at the time of interview. Linear regression models were fitted on height for age z-score and weight for age z-score. RESULTS: In bivariate analysis, child's work status (r = -0.221), household per capita income (r = 0.104), family size (r = -0.102), house m2 per capita (r = 0.090) and monthly expenditure on durables (r = 0.086) were significantly correlated with height z-score. Work status (P < 0.0001) and household m2 per capita (P = 0.002) were retained in the regression model fitted on height z-score which explained 9.8% of the variance. The model fitted on weight z-score explained 6.5% of the variance and work status (P < 0.0001), household per capita income (P = 0.041) were retained. CONCLUSIONS: The results of this study suggest that, independent of a range of socio-economic factors, work has a negative effect on child growth. Given the extent of child labour internationally these findings have profound implications for global child well-being and for global social and economic policy.

Adolescent↗

Social patterning and prediction of parent-reported behaviour problems at 3 years in a cohort study.

OBJECTIVE: To study the determinants of parent-reported behaviour problems at 3 years and the value of behaviour problems reported at 8 and 18 months as predictors of behaviour at 3 years STUDY DESIGN: A whole year birth cohort SETTING: Coventry MAIN OUTCOMES: Parent-reported behaviour problems at 3 years PARTICIPANTS: A total of 2580 infants were enrolled into the Coventry Cohort Study at the birth visit by their family health visitor. Data on parent-reported behaviour at all three ages (8 months, 18 months and 3 years) were available on 775 infants. RESULTS: Living in rented accommodation [adjusted OR 2.38 (95% CI 1.36, 4.21); OR, odds ratio; CI, confidence intervals] and living in a smoking household [adjusted OR 2.47 (95% CI 1.53, 3.99)] were independently associated with parent-reported behaviour problems at 3 years after controlling for other sociodemographic variables in logistic regression. The risk of behaviour problems at 3 years was increased in those reporting behaviour problems at 8 months [OR 3.77 (95% CI 1.73, 8.20)] and 18 months [OR 5.84 (95% CI 3.34, 10.23)] after adjustment for sociodemographic variables and other health problems. Behaviour at 8 months as a predictor of behaviour at 3 years had a sensitivity of 13.9%, a specificity of 95.7%, a positive predictive value of 32.6%, and positive and negative likelihood ratios of 3.23 and 0.90. For behaviour at 18 months, the sensitivity was 35.6%, the specificity 92.9%, the positive predictive value 42.9%, and positive and negative likelihood ratios 5.01 and 0.69. CONCLUSIONS: Parent-reported behaviour problems at 8 and 18 months are highly specific but not particularly sensitive as predictors of behaviour problems at 3 years. Assuming the availability of an effective early intervention, use of a question such as that in the Warwick Child Health and Morbidity Profile at 8 and 18 months will identify, respectively, 21% and 36% of children at risk of parent-reported behaviour problems at 3 years.

Child Behavior Disorders↗

Services for pre-school children with behaviour problems in a Midlands city.

OBJECTIVES: To study the services for pre-school children with behaviour problems in a Midlands city and the level of co-ordination and co-operation between providers. SETTING: A socially and ethnically diverse Midlands city in the UK. METHODS: Survey methods were employed with city health visitors in order to determine their role and identify service providers. Service providers from different agencies were interviewed and data collected related to service offered, materials used, theoretical basis of interventions, referrals to and from the service, inclusion and exclusion criteria and co-ordination and co-operation with other providers. Themes were identified related to the content and process of the services using qualitative data analysis methods. Frequencies of themes were estimated for different provider groups. RESULTS: Health visitors and nursery nurses working in the primary care services were the primary point of contact for children with pre-school behaviour problems. Nursery nurses were one of the major sources of referral for children with pre-school behaviour problems and a significant majority of these providers had not received any specific training for this role. The majority of the providers used evidence-based programmes but few adhered strictly to a particular programme and instead used a mixture of materials drawn from different programmes. Many health service providers in particular offered interventions to parents on a one-to-one basis only. Most providers used behaviour modification approaches. While many providers claimed to have knowledge of other local providers and have good links, there was little evidence of co-ordination within and between agencies. CONCLUSIONS: While there appears to be high levels of activity by providers from both statutory and voluntary sectors in providing services for pre-school children with behaviour problems, there is evidence to suggest that some of the main providers of services are not being adequately prepared and supported in the role. There is a lack of co-ordination within and between services, and indication that evidence-based programmes are being modified and used in an ad hoc manner. It is concluded that surveys of this nature may be an important preliminary step in establishing co-ordinated services for the primary and secondary prevention of pre-school behaviour problems.

Attitude to Health↗

Parent reported longstanding health problems in early childhood: a cohort study.

AIM: To study changing prevalence and correlates of longstanding health problems across early childhood. METHODS: Of 2576 infants enrolled in the Coventry Cohort Study at birth, parents of 2157 at 8 weeks, 1752 at 8 months, 1521 at 18 months, and 1182 at 3 years completed the Warwick Child Health and Morbidity Profile. RESULTS: The prevalence of parent reported longstanding health problems was 4.3% at 8 months, 6.9% at 18 months, and 9.7% at 3 years. Congenital anomalies accounted for 42.1% of longstanding health problems at 8 months, 40.0% at 18 months, and 27.8% at 3 years. The proportion accounted for by asthma was 17.1% at 8 months, 21.9% at 18 months, and 24.3% at 3 years. In each age period, children reported to have longstanding health problems were at increased risk of impaired functional health, poorer general health, and reduced health related quality of life. Low birthweight infants were most at risk of longstanding health problems at 8 months. By 3 years, risk of longstanding health problems was associated with living in rented accommodation and living in a smoking household. CONCLUSIONS: The prevalence of parent reported longstanding health problems increased across early childhood. Congenital anomalies constituted the major cause, particularly in infancy, with asthma and developmental delay becoming more prominent by 3 years of age. Social patterning of longstanding health problems and the association with smoking were clearly established by 3 years of age but the relation may have been mediated by low birth weight earlier in infancy.

Asthma↗

Effect of work related variables on growth among working boys in Jordan.

OBJECTIVE: To study the effect of work related variables on the height, weight, and body mass index (BMI) of working boys aged 10-16 years. DESIGN: Cross sectional survey. SETTING: Irbid, Jarash, and North Jordan Valley in Jordan. PARTICIPANTS: 135 working boys aged 10-16 years and their mothers. OUTCOME MEASURES: Height for age z score; weight for age z score; BMI for age z score. RESULTS: In bivariate analysis, child's duration of work (r=-0.20), maternal height (r=0.26), and household per capita income (r=0.23) were significantly correlated with height for age z score and duration of work (r=-0.24), maternal height (r=0.24), and household per capita income (r=0.19) with weight for age z score. Duration of work (p<0.001), child's monthly income (p=0.044), maternal height (p=0.002), and household per capita income (p=0.005) were retained in the regression model fitted on height z score that explained 20.1% of the variance. The regression model fitted on weight z score explained 20.1% of the variance and duration of work (p<0.001), child's monthly income (p=0.022), household per capita income (p=0.017), and maternal height (p=0.004) were retained. Only duration of work (p=0.001) was retained in the model fitted on BMI for age z score. CONCLUSION: The results of this study suggest that the length of time children have been working and low monthly income have a detrimental effect on growth of working boys independent of the effects of low household per capita income and small maternal stature. Relevance of these findings for social policy and health care of working boys in Jordan and elsewhere is discussed.

Adolescent↗

Nanochemical surface analyzer in CMOS technology.

We have developed an atomic force microscopy (AFM) cantilever system, fabricated using a standard CMOS process and a few post-processing steps, capable of detecting the difference between hydrophilic and hydrophobic samples for the purpose of nanochemical surface analysis. The fully integrated cantilever comprises a thermal actuator for cantilever deflection and a Wheatstone bridge to sense cantilever bending, thus obviating the need for cumbersome laser detection and external piezoelectric drives. Glass microspheres have been affixed to the cantilevers and, were either modified with a self-assembled monolayer to form hydrophobic tips, or left unmodified for hydrophilic tips. Force-distance curves have been used to measure the force between the functionalized/unfunctionalized tips and hydrophobic/hydrophilic sample surfaces. In an optimization step three different Wheatstone bridge sensors have been designed and characterized; best Wheatstone bridge sensitivity is 8.0 microV/nm with a 713 nm/mW actuator efficiency.

Journal Article↗

Growth of working boys in Jordan: a cross-sectional survey using non-working male siblings as comparisons.

OBJECTIVES: To study the effects of work on growth of Jordanian boys, aged 10-16 years, using non-working male siblings as controls. SETTING: The Jordanian areas of Irbid, Jarash and the North Jordan Valley. STUDY DESIGN: Cross-sectional survey of working boys and their non-working brothers. MAIN OUTCOMES: Height-for-age z-score; weight-for-age z-score. METHODS: Working boys (103) and non-working male siblings (103) (nearest in age to the working child) were interviewed, with their mothers, in the family home. Heights and weights of the working boys and their non-working male siblings were measured, and capillary blood was taken for packed-cell volume estimation. Heights and weights were converted to z-scores, and means for all three outcomes were compared between working boys and non-working siblings, using independent sample t-tests. The effect of the proportion of household income contributed by the working child's income on the main outcomes, among non-working siblings, was estimated by simple linear regression. RESULTS: Means for height-for-age z-score (p < 0.001), weight-for-age z-score (p < 0.001), and packed-cell volume (p < 0.001) among working boys were significantly lower than means for their non-working siblings. The main outcomes among non-working siblings were not significantly correlated with the proportion of household income contributed by the working child. CONCLUSIONS: The results of this study suggest that work among boys aged 10-16 years in Jordan puts them at increased risk of stunting, wasting and anaemia. Previous studies have suggested this relationship but have suffered from confounding by socioeconomic status. Comparison with non-working siblings reduces the chances of socioeconomic status confounding.

Adolescent↗

Transfer of stereochemical information in a minimal self-replicating system.

[structure: see text]. The rational design, synthesis, and characterization of a minimal self-replicating system based on a 1,3-dipolar cycloaddition between a nitrone and a maleimide is presented. The importance of molecular recognition in this system is demonstrated using a competitive inhibitor. Doping experiments demonstrate that only one of the two diastereoisomeric products of the cycloaddition reaction is capable of acting as an efficient template for its own formation, accelerating the reaction between the nitrone and maleimide and controlling the stereochemical outcome of the reaction.

Journal Article↗

Work, family socioeconomic status, and growth among working boys in Jordan.

AIMS: To describe the work, family socioeconomic characteristics, and growth of a representative sample of working children in Jordan. METHODS: In a cross sectional survey of growth and health, 135 working children (aged 10-16 years) were studied in the areas of Irbid, Jarash, and North Jordan Valley. The children and their parents were interviewed and data collected on length of working week, income earned by the child, duration of work in years, age of starting work, type of work, child's smoking status, and family socioeconomic status. RESULTS: The mean age of the children was 13.3 years; 14.8% had started work before the age of 10 and 12.6% had been working for more than four years. Mean income was 34 Jordanian Dinars but 6.7% were unwaged; 34% were working more than 60 hours per week, and 85.9% more than 40 hours. Monthly income and working hours were positively correlated with the age of the child. There was no correlation between age and smoking status; 37.8% smoked more than five cigarettes per day. Mean height and weight z scores were -0.365 and -0.081 of the UK standard respectively. Packed cell volume was within the anaemic range in 34.1% of children. CONCLUSIONS: In Jordan many children start work at an early age and work long hours for little or no income. Stunting and anaemia are common and many are established smokers. Relevance of these findings for social policy and health care of working children in Jordan and elsewhere is discussed.

Adolescent↗