Biomedical subjects
N Simpson
Publications and source records attributed to N Simpson.
Treating hyperhidrosis.
Explore the source record for details and available documents.
Ligands for imaging opioid receptors in conscious humans by positron emission tomography (PET).
Explore the source record for details and available documents.
Memory assessment using the Strub-Black Mental Status Examination and the Wechsler Memory Scale.
A systematic mental status exam often can differentiate accurately patients with organic brain disease from normal persons and those with functional disorders. The present study attempts to validate the memory portion of the Strub-Black Mental Status Exam by comparing it to the Wechsler Memory Scale. Twenty-five brain-damaged and 25 routine medical patients were given Form I of the Wechsler Memory Scale and the memory portion of the Strub-Black Mental Status Exam at their hospital bedside. Results indicate significant differences in almost all scores between the brain-damaged and normal groups on both the Wechsler Memory Scale and Mental Status exam; the Mental Status Exam differentiated between groups at a higher level of significance of ANOVA and ANCOVA comparisons of total memory scores, as well as several subtests. In these samples, age, more than education, was an important factor that affected memory test performance. The Mental Status Examination appears valid for the differentiation of clinical samples and for the documentation of specific aspects of memory dysfunction in individual brain-damaged patients. This study represents a beginning step in providing normative data on components of the Strub-Black mental status examination.
Adrenergic mechanisms in the control of plasma lipids in man.
The effects on plasma lipids of beta-blocking antihypertensive agents with differing degrees of selectivity and intrinsic sympathomimetic activity were studied. The interrelationship between changes in lipid factors, lipoprotein lipase function, the degree of response, and pretreatment characteristics were examined. Beta-adrenergic blockade increased plasma triglycerides but decreased high-density lipoprotein cholesterol. Cardioselective drugs (atenolol and metoprolol) had less effect on triglyceride and very low-density lipoprotein cholesterol than the nonselective beta blockers (propranolol and oxprenolol). Inhibition of lipoprotein lipase was suggested by a reduction of the fractional removal rate of triglyceride in conjunction with increased total and very low-density lipoprotein cholesterol levels and reduced high-density lipoprotein cholesterol. Consistent decreases in free fatty acids lend argument against elevated triglyceride synthesis.
Neurotoxicity associated with therapeutic serum lithium levels.
Explore the source record for details and available documents.
Metabolic consequences of atenolol and propranolol in treatment of essential hypertension.
A six-month study of triglyceride, cholesterol, free fatty acid (FFA), glucose, insulin, growth hormone, and glucagon concentrations was carried out in asymptomatic hypertensive normal-weight men randomly allocated to treatment with atenolol or propranolol. A highly significant increase in the basal plasma triglyceride concentration was observed in propranolol-treated patients after three and six months' treatment, with a smaller but significant increase in atenolol-treated subjects after six months' treatment. The changes in triglyceride concentration could not be ascribed to variations in plasma insulin, growth hormone, or glucagon concentrations. Basal FFA concentrations were reduced during the first three months of treatment in both groups but returned to pretreatment levels after six months. Plasma cholesterol concentrations were unchanged by either agent.
Interaction of normal and unusually modified microbial DNA with cultured mammalian cells. Breakdown and reincorporation vs. uptake of polymerized DNA.
The uptake of radioactively labeled bacterial and phage DNA and the incorporation of acid-soluble DNAase I digests of these DNAs by cultures of human foreskin and 3T3 cells were studied. The presence of large amounts of unusually modified pyrimidine residues in donor phage DNAs allowed radioactive donor DNA in the nuclei of DNA-treated cells to be distinguished from host DNA labeled with breakdown products derived from donor DNA. This distinction could be made because it was found that radioactively labeled 5-methylcytosine residues in predigested XP-12 DNA and glucosylated 5-hydroxymethylcytosine residues in predigested T4 DNA could not be incorporated in an unaltered form into animal cell DNA. The results obtained from the study of uptake of these DNAs suggest that approx. 4--40 ng of phage DNA per 10(6) cells was transported to the nuclei of DEAE-dextran-pretreated cells during 3 days of incubation in medium after treatment with the DNA. However, interpretation of the results is complicated by the finding of considerable amounts of donor DNA binding to and persisting at the cell surface, which might attach to nuclei during subcellular fractionation.
Effects of calcitonin therapy in deafness associated with Paget's disease of bone.
Explore the source record for details and available documents.
The Sheffield region. Development and future plans for physical medicine and rheumatology.
Explore the source record for details and available documents.
East-West conflict in child of a "mixed" marriage.
Explore the source record for details and available documents.
The second foreign body in children.
Explore the source record for details and available documents.
Pruritus in diabetes mellitus: investigation of prevalence and correlation with diabetes control.
Three hundred diabetic and 100 nondiabetic hospital outpatients (both groups of comparable age and sex distribution) were assessed for the presence of generalized and localized pruritus. Pruritus vulvae was significantly more common in diabetic women (18.4%) than in controls (5.6%) and was significantly associated with poor diabetes control (mean glycosylated hemoglobin level less than 12%). Other forms of localized pruritus were equally common in diabetic and nondiabetic patients, regardless of glycosylated hemoglobin levels. Generalized pruritus was present in 14 diabetic patients, but in 5 cases the symptom was ascribed to intercurrent illness or drug administration. Thus, generalized pruritus without apparent cause was present in only 8 diabetic patients (2.7%) and was not significantly more common than in nondiabetic patients. It is doubtful if diabetes mellitus per se should be regarded as a cause of generalized or localized pruritus, other than pruritus vulvae.