[Research on blood acetoacetate, pyruvate, lactate and citrate in chronic hyperazotemic renal insufficiency].
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Acetoacetates↗
Biomedical subjects
N Siliprandi
Publications and source records attributed to N Siliprandi.
On the biochemical significance of phosphoserine: a working hypothesis.
The significance of the presence of free phosphoserine in living cells represents an intriguing problem. Its utilization for the synthesis of phosphoproteins and phospholipids has been ruled out. It is produced extensively by hydrolysis of phosphoproteins or phosphatidylserine since no phosphorylating enzyme for serine is present. So far the only significance of phosphoserine has been related to its participation in the exchange reaction with serine, the meaning of which is quite unclear. Evidence is presented that phosphoserine could modulate the activity of phospholipase A2, thus regulating the permeability properties of cellular and intracellular membranes which depend largely on phospholipase pattern. Phosphoserine in fact inhibits in a competitive way phospholipase A2 from cobra venom.
Animals↗
On the transport mechanisms of carnitine and its derivative in rat heart slices.
The transport of L-carnitine and analogs in exchange with previously loaded 3H-carnitine has been studied in heart tissue slices. The slices are first loaded with 3H-carnitine; then they are transferred in vessels containing the same medium with possible exchangers. Acetylcarnitine, L-carnitine, D-carnitine and deoxycarnitine exchange with internal 3H-carnitine. The exchange with acetylcarnitine, the largest among the compounds tested, appears to be a saturation process and is not affected either by oxidative phosphorylation and glycolysis inhibitors. The exchange of external acetylcarnitine with internal carnitine support that also in vivo heart tissue can utilize acetylcarnitine present in blood. Finally the observed deoxycarnitine/carnitine exchange, occurring in the reverse direction, may be the mechanism by which the heart accumulate external carnitine in exchange with endogenous deoxycarnitine.
Animals↗
[Support for the parents after the death of a newborn infant].
The neonatologist in NICU has many duties, first of all caring the baby and supporting the parents in facing stressing situations. When the baby dies most doctors think their job is over, and only in few hospitals there is the opportunity for the parents to meet the staff again. We report our recent experience to meet parents after baby's death. We offer them this possibility when they are leaving the hospital and, after about one month, we call them by phone to arrange an appointment. We have realized that they need to talk at least once with the staff (doctors and nurses) to examine and solve doubts about cares and to relieve their sufferance. In our experience, even limited, we found that nobody refuses this opportunity and that in most instances parents required more than one meeting and, finally, that talking of the baby with people who took care of him helps them in accepting baby's death. We found this experience very useful both for parents and staff, so we hope this opportunity will extend to other hospitals.
Adult↗