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Biomedical subjects

N Shigematsu

Publications and source records attributed to N Shigematsu.

At least 163 records · Page 9Linked to original sources
PubMed1982

A possible role of a nonadrenergic inhibitory nervous system in airway hyperreactivity.

To investigate a possible role of a nonadrenergic inhibitory nervous system in airway hyperreactivity, we measured changes in RL and CL caused by electrical stimulation of cervical vagus nerve during the infusion of 5-HT, after treatment with atropine and propranolol in 18 cats. RL decreased to 56 +/- 3% (mean +/- SE) and CL increased to 186 +/- 13% of the prestimulated values, respectively, after stimulation. Hexamethonium diminished these responses significantly. Airway reactivity to 5-HT was reduced by continuous electrical stimulation of cervical vagus nerve in cats pretreated with atropine and propranolol. Hexamethonium potentiated airway reactivity to 5-HT. These results suggest that a nonadrenergic inhibitory nervous system could play an important role in the control of the bronchomotor tone and contribute to airway hyperreactivity.

Airway Resistance↗
PubMed1980

Giant cell carcinoma arising in a pulmonary bulla.

A 57-year-old male showed an abnormal mass shadow in a pulmonary bulla. Thoracotomy was performed and it was ascertained histologically that the tumour was a giant cell type carcinoma. Clinical features, histological findings and prognosis are reported.

Carcinoma↗
PubMed1979

Histopathological factors predictive for prognosis of lung cancer.

This study was done on 110 lung cancer patients who had received surgical resection consisted of two groups; one group of 43 who survived more than 5 years without recurrence and the other group of 67 who died within one year following surgery. Prognostic significance of the histopathological features at the primary tumor site as well as the regional lymph nodes were compared between the two groups. Blood vessel invasion by the tumor and lymph node metastasis appeared to be equally significant prognostic factors. Patients having the both factors had little chance for survival. Abundant lymphoid cell infiltration around the tumor was associated with longer survival. Lymphoid cell infiltration at the site of blood vessel invasion also was associated with better prognosis. Follicular hyperplasia and paracortical hyperplasia in the regional lymph nodes were favorable prognostic indicators, whereas sinus histocytosis was poorly significant prognostic indicator.

Adenocarcinoma↗