Biomedical subjects

N Serrallach Mila

Publications and source records attributed to N Serrallach Mila.

At least 19 recordsLinked to original sources

PubMed2005

[Retrospective study of 130 patients with organconfined prostate cancer treated with brachytherapy].

INTRODUCTION: The prostate brachytherapy with I 125 seeds has an indication in patients with organconfined prostate cancer. Our objective is to describe the population treated in our institution with permanent I125 seeds implants, the dosimetric characteristics of the technique and the preliminary results of our group-study in terms of evolution and toxicity. MATERIAL AND METHODS: Between May 2000 and March 2003, 130 patients with permanent implants of I125 seeds were treated. Beforehand we did prostate volumetric with transrectum prostate echography in order to assess the configuration of the implant, number of seeds and their place in the prostate with the objective to get a fine coverage of PTV (planet target volume). Stage distribution: 75.72% T1c; 24.28% T2a; Gleason<6, 94%. The PSA pretreatment average was 6.38 ng/ml. The average prostate volume was 30 cc. The 16.67% of the patients included had hormonal treatment previously to get the implants. The average age was 64 years. The characteristic techniques of the implants were: the average width of the needle as 24 (14-35) and the average of the seeds 76 (46-111). Finally the average activity was 0.39 mCi/seed, which means average total implant activity of 80 mCi. RESULTS: We analyzed 130 patients with average follow up 6 months. A 1 to 2 year surveillance was carried out on 98.9% and the global free disease surveillance (biochemic relapse) of 98.9% at the year and of the 87.8% at the end of the 2 years. The relapse in the low risk patients was 98.8% after the first year and 88.7% at the end of 2 year. On the contrary in the middle risk was of 100% and 83% respectively, although the amount of patients in significantly less. As a relevant acute secondary effects we found slight rectitys or GI (RTOG scale) in 1.4 and that needs synthomatic medication or GII (RTOG scale) in 0.8%. We found slide hematuria or GI (RTOG scale) in the 53% and other measures or GII (RTOG scale) in the 2.64% was needed. Finally we had to set a urinary prove for acute retention in 4.3%. CONCLUSION: The prostate brachyterapy is a complex procedure that needs a multidisciplinary team participation in order to be able to carry out. It avoids a long term hospitalization and allows for the patient to have daily activity within a short period of time. Despite the fact of the brief follow-up, the results over biochemical relapse and toxicity were similar to the ones in the literature. Tolerance to the implant was good. It would necessary a longer follow-up in order to be able to come to long term conclusions.

Brachytherapy↗

PubMed2001

[Incidence and treatment of urinary lithiasis in renal transplantation].

INTRODUCTION: Urinary calculi is an uncommon complication in kidney transplantation; several stone risk factors are found in transplanted patients, but in most cases there is not a relationship between these risk factors and stone formation. The treatment of these patients is complex due to their both immunosuppressive status and border-line renal function. MATERIAL AND METHOD: From 1980 to February 2000, 1198 kidney transplant have been performed in our institution. We describe our series consisting in 22 urinary calculi (15 in the graft, 3 in the urether and 4 in the bladder) in 18 patients, including 7 stones detected in cadaveric donor patients. RESULTS: We performed external shock wave lithotripsy in 7 patients, bench surgery in 4, endoscopic mechanic lithotripsy in 5, open surgery in 1 and observation in 6. Calcium oxalate (mono and dihidrate) was found in 9 of 13 calculi. Metabolic changes were found in 15 of the 18 patients, the most common was hiperuricemia. There were not complications of every treatment applied and 9% of them needed a savage treatment. We found recurrence in 4 cases (22.2%). Now 12 of the patients are stone-free (66.7%) and three have non-significative stones (83.3% without symptoms). CONCLUSIONS: Detection of renal calculi in cadaveric renal donors is not a reason to refuse the graft for further transplantation. In both renal calculi up to 2 cm and uretheric calculi surgical treatment is assessed as first option. In caliceal stones smaller than 5 mm observations is the best treatment.

Humans↗

PubMed2001

[Iliac pseudoaneurysm in non-functioning renal graft 10 years after embolization].

The arterial pseudoaneurysms are an infrequent complication or renal transplantation. Depending on her localization, are divided in intra and extrarenal. The first are relacionated with the practice of percutaneous needly biopsy. The seconds are associated with defects of vascular anastomose or infection onsurgical area (with relative precocious presentation). Presentation of case of a iliac pseudoaneurysm in non-functional kidney allograft embolizated ten years before. This pathology, for this clinic gravity, requires urgent surgical treatment.

Adult↗

PubMed1998

[Diverticulum of the female urethra: presentation of 3 cases].

Contribution of three cases of female urethral diverticulum diagnosed and treated in our Service. Presence in women presenting to the practice with chronic signs and symptoms of the lower urinary tract unresponsive to conventional medical management should be ruled out. A review is made of the most significant aspects in terms of clinical presentation, diagnosis and therapeutic options.

Adult↗

PubMed1998

[Role of electrohydraulic extracorporeal shockwave lithotripsy (Dornier HM 4) in the treatment of caliceal diverticulum lithiasis].

UNLABELLED: Caliceal diverticula may be congenital or acquired malformations of the collecting system, normally asymptomatic and discovered during an IVP. Indications for treatment included chronic vague flank pain, acute renal colic, urinary tract infection and hematuria. We present the results of 29 patients with symptomatic calculi in caliceal diverticula who were managed by ESWL monotherapy. All treatments were performed with electrohydraulic machine (Dornier HM 4) in ambulatory form. RESULTS: The average followup was 42 months. 12 patients (40%) had passed successfully all of the stone fragments, while 2 patients (7%) had passed more than half and 4 (13.5%) had passed less than half of the fragments. 66 per cent of patients had been rendered free of symptoms. The possibility of producing a satisfactory result (66% free of symptoms and 40% stone free by X ray) and the low morbidity of ESWL suggest that this treatment may be appropriate for majority of calculi in calicea diverticula.

Adult↗

PubMed1997

[Primary adenoma of the female urethra].

Primary melanoma of the female urethra is very rare. Early diagnosis is very difficult and thus involves a long-term non-resolutive therapeutic approach. This paper presents the case of a 61-year old female patient with this type of tumour and nodular dissemination at the time of diagnosis. The patient developed lung and cranial metastasis with 5-year survival.

Female↗

PubMed1997

[Renal hematoma after shockwave extracorporeal lithotripsy].

OBJECTIVE: Renal haematomas after shock wave extracorporeal lithotripsy (SWEL) represent a potentially serious complication. This paper examines those cases of post-SWEL renal haematoma seen in our Centre, analyzing the likely risk factors. PATIENTS AND METHODS: Between May 1988 and June 1996, 12,800 patients were treated with 15100 lithiasis at some level of the urinary tract requiring 16,000 SWEL sessions. All treatments were done with a Dornier HM-4 lithotripter. Voltage applied ranged from 18 to 26 Kv, averaging 2500 waves/session. Complementary testing (ultrasound/computerised tomography) was requested immediately after treatment if clinical complications were suspected. RESULTS: A total of 10 renal haematomas (0.078%) were diagnosed. Six cases were mild, but 4 presented extensive haematoma with significant haemodynamic consequence. Although in one case nephrectomy was undertaken to control haemorrhage, death finally occurred by disseminated intravascular coagulation. Four patients who developed haematoma were hypertensive and 3 had a previously corrected haemostasis alteration. CONCLUSIONS: The possibility of renal haematoma should be taken into account in the face of persistent and unjustified pain after SWEL treatment. Normalization of blood pressure values, correction of urinary infection as well as adequate correction of haemostatic disorders is advisable.

Adult↗

PubMed1996

[Kidney transplantation with donors in heart block. Long-term results].

OBJECTIVES: The shortage of renal grafts has led to the search for other alternatives. The use of grafts from non-heart-beating donors (NHBD) can increase the number of transplants 8% to 20%. Clinical studies conducted by different groups, have found that the long-term graft and patient survival are not different from those of recipients of kidneys from heart-beating donors (HBCD). METHODS/RESULTS: The long-term results of a group of 52 recipients of NHBD kidneys were compared with those of 98 recipients of HBCD grafts. There were no differences in donor and recipient ages, HLA compatibility, reperfusion and cold ischemia times. There were no differences in the incidence of rejection episodes or non-functioning kidneys. Warm ischemia between 30 to 60 min or < 30 min did not influence the incidence of non-functioning kidneys. However, NHBD graft recipients had a higher incidence of acute tubular necrosis (67% versus 46%), recovers of renal function was slower, the duration of oliguria was longer and dialysis was required. The 8-year actuarial survival data were similar for both groups; 65% for the NHBD and 70% for the HBCD graft recipients. CONCLUSIONS: We can conclude that NHBDs are an important source of donor kidneys. The 12 points established by The First International Workshop on Non-Heart-Beating Donors which appear at the end of the present article are embodied in the Treaty of Maastricht regulations of organ transplantation from non-heart-beating donors.

Actuarial Analysis↗

PubMed1994

[Renal angioscopy].

Presentation as a novelty of the application of endoscopic methods in the display of the renal artery (angioscopy). Review of findings seen in the renal artery of a donor corpse with polytraumatism using direct view with a MiniScope-type rigid urethroscopy and the possible future application of this technique.

Angioscopy↗

PubMed1993

[Transplantectomy today: indications and complications].

Analysis of the indications for transplantectomy and its complications over a 12-year period. Over a total of 159 failure grafts, we performed 53 transplantectomies (33.3%). The percentage of complications was 16.9%. Three patients died (5.6%) during the more or less immediate post-operative period. In our experience, consistent and prolonged maintenance of immunosuppression should avoid the need for transplantectomy in a high percentage of grafts. Only 15 transplantectomies were made on 104 failure grafts after 6 months (14.4%). Our short but successful experience with embolization of 2 rejected grafts confirms the validity of this conservative alternative versus conventional surgical transplantectomy in selected cases.

Humans↗

PubMed1993

[Arteriovenous fistulae following percutaneous renal biopsy in renal transplantation. Selective arterial embolization].

Five cases of clinically severe arteriovenous fistulae (AVF) secondary to percutaneous renal biopsy in patients carrying a functional renal graft were diagnosed and treated in our centre. Occlusion via superselective intraarterial embolization accomplished successful control in every case. We insist on the therapeutical value of this minimally invasive technique, which furnish it with a particularly relevant role in renal transplantation.

Adult↗

PubMed1993

[Renal angiomyolipoma. Our case histories].

We reviewed the cases of angiomyolipoma that had been diagnosed and treated in our urology services from 1978 to 1991. The study showed a higher incidence in the females; it frequently presented as a solitary tumor; a high specificity was found for the US (hyperechoic mass) and CT (areas of low attenuation ratio) findings. Owing to these diagnostic techniques, conventional surgery is no longer the only treatment. Embolization is considered to be the first therapeutic approach.

Adult↗

PubMed1992

[Renal transplantation in patients over 50 years old: our experience with 58 cases].

Retrospective analysis of the results from corpse renal transplantation, under immunosuppressive therapy with cyclosporin in a group of 58 elderly receptors (greater than or equal to 50 yr). The results are compared with those obtained in 152 receptors under 50 year of age transplanted during the same period of time (1984-1988). No statistical differences were seen between both groups regarding immunosuppressive therapy, number of transfusions, HLA histocompatibility, number of transplantations and percentage of hypersensitive patients. Incidence of rejection is significantly higher in the younger patients group, as well as graft loss due to immunological reasons. Mortality was significantly higher in the elderly group. Actuarial survival of the graft after two years is similar in both groups. It is concluded that in the era of cyclosporin, the receptor's age should still be considered a risk factor and, therefore, that maximum precautions should be taken in order to detect any additional risk factor within this group in a strategy to improve their survival.

Adolescent↗

PubMed1989

[Fibrous polyp of the ureter].

We report on a 72-year-old male patient with fibrous ureteral polyp which had been diagnosed following the incidental finding of a ureteral filling defect on radiographic evaluation for prostatism and gross intermittent hematuria of several months. We underscore the low frequency of this disorder and the therapeutic implications of differential diagnosis to distinguish this condition from other causes of ureteral filling defects.

Aged↗

PubMedDate not supplied

[Partial nephrectomy in renal cell carcinoma].

INTRODUCTION AND OBJECTIVES: Renal Cell Carcinoma (RCC) represents 3% of all neoplasm. The growing incidental diagnosis of small renal tumor has allowed the application of nephron sparing surgery (NSS), even in those cases with a normal contralateral kidney. We present the results of NSS at our center in the last decade. MATERIAL AND METHODS: A retrospective analysis of all NSS that were made at our center in cases of renal masses. Difference is made between elective surgery (tumors less than 4 cm with a normal contralateral kidney) and obligatory surgery (all other cases). RESULTS: From 1990 since 2000 a total of 65 NSS were made from a total of 436 surgeries for renal tumors (14.9%). In 22 patients NSS was obligatory, while in 43 was elective. Mean (SD) age was 59.1 years (+/- 11.7), mean tumor size 3.4 cm (+/- 1.4), mean hospital staying was 9.2 days (+/- 7). Renal normothermic ischaemia was use during surgery in all cases, with a mean ischaemic time of 25.7 min. Nine tumors (13.8%) were benign. Morbidity: 10.8%. Mortality: 1.5%. The cancer specific survival at 36 months of follow-up (mean 37.4) is 98.4% and global survival is 90.3%. CONCLUSIONS: Nephron Sparing Surgery is a valid alternative in the treatment of RCC, specially for tumors less than 4 cm in diameter and having a normal contralateral kidney; NSS is also an effective technique for patients bearing renal tumors in a solitary kidney.

Adult↗

PubMedDate not supplied

[Penile and urethral lesion caused by metallic ring. Reconstruction with radial free flap].

We report a case of a man with a severe penile injure caused by a metallic ring placed in the penile shaft for 48 hours, it coursed with partial urethral section and ischemia of the whole penile skin and dartos. It was solved with surgical excision of all death tissue and posterior reconstruction using a forearm free flap, the vascular supply came from epigastric vessels, we used hair-free skin from forearm for the urethroplasty. Ethetic and functional results obtained are successful.

Foreign Bodies↗

PubMedDate not supplied

[Treatment with the Newbit technique in patients with Peyronie's disease].

OBJECTIVE: Evaluate the results of Nesbit's technique in patients with Peyronie's disease. METHODS AND MATERIALS: Between 1990 and 2002, 45 patients were treated using the Nesbit's procedure to correct Peyronie's disease curvature. Mean age was 57.6 (range 41-73). Dorso lateral incurvation was the most common. RESULTS: Total correction of the curvature in 40 patients (88%). High grade of satisfaction in 39 patients (86.66%). CONCLUSION: Nesbit's operation is an easy and effective surgical technique in the peyronie's disease for curvature correction.

Adult↗

PubMedDate not supplied

[Preservation by pulsatile perfusion machine: the initial experience].

The increasing numbers of patients in a waiting list for a renal transplantation together with the epidemiological changes in donor's characteristics have given rise to a growing interest in preservation with pulsatile perfusion machines. The availability of objective predictive parameters of renal functioning after transplantation as well as of improving preservation to reduce the incidence of acute tubular necrosis (ATN) are the major features of this preservation technique. This paper presents our experience in preservation with pulsatile perfusion machines which have allowed us to have objective parameters to assess an organ's future functioning and to improve, as far as possible, the quality of treated kidneys preservation.

Adult↗