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Biomedical subjects

N Senninger

Publications and source records attributed to N Senninger.

At least 91 records · Page 5Linked to original sources

[Results of double kidney transplantation from elderly donors].

From July 1996 to November 1997 13 patients underwent "two-in-one"-kidney transplantation from marginal donors. Up to now all renal grafts show a stable function measuring an average creatinin of 1.73 mg/dl after an average follow up of 8.2 month. To take the decision between "one-in-one" or "two-in-two" transplantation in marginal donors we developed a specific score. This score needs more evaluation because of the still small amount of patients undergoing double-kidney-transplantation.

Age Factors↗

[Effect of proctocolectomy on fluid balance--comparison of conventional ileostomy, ileorectal anastomosis and ileoanal pouch operation].

Total colectomy for ulcerative colitis (UC) and familiar adenomatous polyposis coli (FAP) is mainly performed as an ileoanal Pouch procedure (IAP). Alternatives are ileorectal anastomosis (IRA) and conventional proctocolectomy with Brooke ileostomy (CPS). The different surgical techniques may influence the excretion of water and electrolytes in stool and urine and may lead to a higher risk for urolithiasis. We investigated patients (12 IAP, 12 IRA and 8 CPS) several years after surgery and compared them to twelve normal controls. Total fecal and urinary output was collected at two consecutive days. Volume and electrolytes were determined in stool and urine. The risk for urinary stone formation was calculated by nomograms. Fecal volume and sodium (Na+) excretion was increased in all therapy groups compared to controls. IAP and IRA had significant less stool volume and Na+ excretion compared to CPS. Augmented fecal Na+ excretion was compensated by reduction of renal output after colectomy compared to controls. There were no significant differences in the daily urine volume between any groups. There was no urolithiasis in any groups. The nomograms showed a risk for all groups and controls to develop urinary stones.

Adenomatous Polyposis Coli↗

[Esophageal carcinoma. Staging and necessary preoperative diagnosis].

The routine examination in esophageal carcinoma includes the following established recommendations: endoscopy with biopsy--X-ray of the esophagus--endosonography--cervico-thoraco-abdominal CT scan--bronchoscopy in tumors of the upper half of the esophagus. Diagnostic laparoscopy is gaining increasing importance, especially with regard to the distal adenocarcinoma of the esophagus. Other new diagnostic tools directly influencing clinical practice are magnetic resonance tomography, positron emission tomography and possibly the detection of circulating or bone marrow tumor cells.

Bronchoscopy↗

[Indications for restorative proctocolectomy in systemic colorectal diseases (ulcerative colitis and familial adenomatous polyposis coli)].

Restorative proctocolectomy is now the procedure of choice for patients suffering from ulcerative colitis (UC) and familial adenomatous polyposis coli (FAP). The majority of patients with UC require surgery for failure or development of side effects of medical therapy. Other indications include dysplasia, carcinoma and complications from either medical therapy or the disease, such as massive bleeding or perforation. In the adolescent patient, resection may be necessary owing to growth retardation. In patients with FAP the 100% risk of developing colorectal carcinoma can be avoided only by proctocolectomy. Crohn's colitis and carcinoma of the lower rectum represent absolute contraindications. A relative contraindication exists in indeterminate colitis, patients with poor sphincter function, mesenteric desmoids, obesity and an age above 65 years.

Adenomatous Polyposis Coli↗

[Guidelines and recommendations for a successful congress abstract].

The title and introduction of the abstract must clarify the intention of the study. The methods part must define the study and control groups and the statistical methods of comparison. In the results part, the data must be presented clearly, possibly in tables or graphs, interpretations must be strictly omitted. The text and the tables must not be redundant. The part discussion and/or conclusions may have the greatest variability. It is important, however, that the data presented support the interpretation and conclusion. And last but not least: the promise of too many additional studies may be unrealistic.

Abstracting and Indexing↗

[Clinical anatomy in surgical education and graduate education].

On the basis of the experience that knowledge of anatomy is not as sound in clinical education as it should be and with a view to the new licensing regulations for physicians, at the Westfälische Wilhelms-Universität Münster, Germany, we established an interdisciplinary anatomical education. Clinical practitioners from 14 different specialties together with anatomists give lessons in applied anatomy accompanying the dissection course, and clinical experienced anatomists guide senior medical students in parallel to the practical courses to refresh their anatomical knowledge. Conjointly clinical practitioners and anatomists initiate, organize and establish meetings in postgraduate surgical education and experimental surgery. All seminars are evaluated and have a very good compliance.

Anatomy↗

[Length of overseas research sojourn in the career path of academic surgeons].

Since there are no data concerning the results/efficiency of research stipends in foreign countries, the aim of this study was to analyze the experience of German surgeons doing research work abroad. Seventy-four fellows (residents) in surgical training who conducted research outside Germany between 1986 and 1995 have been interviewed using a detailed questionnaire. Back in Germany, the results and the experience gained from research abroad led in the majority of cases to a post doctoral degree, a high number of publications, as well as to intensified research efforts in the same field, using the methods learned abroad. Back home, the possibilities of pursuing research were often compromised by clinical workload. In general, better support for researchers in terms of better clinical and scientific perspectives is urgently needed, a demand that is voiced in numerous comments.

Career Choice↗

[Graduate education for specialist in surgery in the USA--aspects for the young German and American physician].

Due to high standards in clinical practice and outstanding research opportunities in the USA, German residents wish to do a part of their surgical education in an American teaching hospital. Currently, German applicants must have an unrestricted license and a valid Standard ECFMG Certificate. For this certificate they must have passed Step I and II of the United States Medical Licensing Examination, which also includes an English test. The examination requirements are about to be changed. A 1-year participation in one of the 267 surgical residency programs is generally not possible. In Germany, American residents have the opportunity to apply for a supervised training year without passing the German medical exams. At present, there are no clinical exchange programs in surgery between Germany and the USA. Therefore, the German and American College of Surgeons should develop an exchange program for residents in surgery.

Curriculum↗

[Preoperative staging of stenosing esophageal carcinoma--prospective comparison of mini-endosonography with conventional endosonography].

Staging of esophageal malignancies can easily and safely be performed with ultrasonic miniprobes. Unlike large-diameter ultrasonic instruments, miniprobes may pass even high-grade malignant esophageal strictures without prior bouginage. Image quality and resolution of miniprobe sonography exceeds that of conventional endosonography, thus achieving higher accuracy rates for T staging, while those for N staging have found to be similar. As miniprobe sonography is able to improve patients' convenience and security and is highly cost effective compared to conventional endosonography, miniprobe sonography appears to be a valuable addition to the staging armamentarium in esophageal carcinoma.

Adenocarcinoma↗

[Prognostic differences in primary malignancies of the small intestine].

Malignant small bowel tumours are rare, with about 320 deaths every year due to metastases. Tumours of differing histologic entitites (adenocarcinomas, leimyosarcomas, non-Hodgkin, lymphomas, carcinoids) are detected at late stages of the disease because of non-specific symptoms. Valuable diagnostic means are small bowel enema, intestinoscopy and abdominal CT/ultrasound. Five-year survival rates are poor for carcinomas (21%), for sarcomas (37%), lymphomas (44%) and best for carcinoids (100%). Surgical options are poor for carcinomas with a high number of R2 resections and bypass operations. Multivisceral surgery is beneficial for sarcomas and lymphomas, followed by local radiation therapy or chemotherapy.

Adolescent↗

[Can noninvasive gadolinium 3D MR subtraction angiography of visceral arteries replace conventional intra-arterial catheter angiography?].

Classic catheter angiography is compared with 3D gadolinium MR angiography for evaluation of the vascular anatomy of the celiac trunk, liver supplying arteries, and the portal venous system. Based on 10 patients, this study shows the value of this new non-invasive method of angiography for the diagnosis of visceral vascular anatomy. For this diagnosis MR angiography is expected to replace conventional angiography in the near future.

Angiography↗

[Outcome of surgical therapy in asymptomatic primary hyperparathyroidism].

Surgery for symptomatic hyperparathyroidism remains the standard therapy. Asymptomatic primary hyperparathyroidism (pHPT) is being diagnosed with increasing frequency owing to broad serum testing. Indications for surgery in this setting are controversial. For evaluation of surgical safety we performed a retrospective analysis of our patients who were being operated on for asymptomatic pHPT. From January 1988 until August 1995, 243 patients were treated for pHPT and registered prospectively at our unit. Seventy-six patients were classified as asymptomatic. In all, 75% of the patients were female; the mean age was 62 years. In this group, 87% of the patients had cervical sonography in order to localize the adenoma. Highly selective venous catheterization was required in cervical reexplorations. Statistical analysis for potential prognostic factors for the clinical outcome was performed. Successful cervical exploration was possible in 71 patients (94.7%). With 4 patients remaining hypercalcemic, the rate of persistency was 5.2%. Localization procedures were correct in 58% for cervical ultrasound and 77% for selective venous catheterization. Postoperative morbidity included one permanent recurrent laryngeal nerve palsy and 2 patients with hemorrhage who were treated by reoperation. While one case of permanent hypoparathyroidism was well controlled by oral supplementation, 18 patients recovered from temporary hypoparathyroidism. No postoperative mortality occurred. Risk factor analysis revealed only cervical reexplorations for HPT to be associated with a higher morbidity (P = 0.02). Surgery for asymptomatic pHPT can be performed with reasonable safety. Cervical reexplorations in asymptomatic patients should be reserved for special indications. Apart from this small group, all patients should be evaluated for surgery.

Adult↗

[Transtracheal monitoring of the recurrent laryngeal nerve. Prototype of a new tube].

A new sensing device for the continuous intraoperative monitoring of the recurrent laryngeal nerve is presented. It is based on a double ballooned endotracheal tube including stimulating and tracing electrodes. The system is characterised by three advantages: 1) it is atraumatic, 2) it is operating completely outside the operating field (extraterritorially), 3) nerve function is being monitored continuously from the time of intubation to the time of extubation. The presented system has been evaluated in piglets. First results in humans will be available shortly.

Animals↗

[The patient with respiratory problems].

Despite improvements in operative and anesthesiological techniques, respiratory problems in surgical patients have been minimized but not eliminated. In addition to risks which are typical for the individual patient, the perioperative respiratory morbidity is affected by anesthesiological manipulations as well as the operation and the nature of the operation (elective versus emergency). In this paper, after describing anesthesia-associated disturbances of the respiratory situation together with worsening due to the disease in patients with COLD, techniques and methods for therapy, prophylaxis, and prognostic assessment are delineated. Two examples are given for patients with respiratory problems (abdomino-thoracic esophageal resection as a example of local trauma in patients with numerous preoperative risk factors and acute necrotizing pancreatitis to describe the sequelae of a toxic process). The essence of our discussion is that, prognostically, preoperative diagnosis is of reduced value. Only a synopsis of clinical findings together with spirometry and blood gas analysis appears to be relevant. Early mobilization in conjunction with excellent postoperative pain therapy is of utmost importance, which is equivalent to the almost routine placement of a patient controllable epidural analgesia technique. These concepts have shown in the two patient groups described that respiratory morbidity may be reduced significantly. Cooperation between surgeons and anesthesiologists, which is characterized by complete and mutually high competence on both sides, is essential for successfully managing patients at increased respiratory risk.

Anesthesia, Epidural↗

Common biliary-pancreatic conduit stenosis induces pancreobiliary reflux.

A striking pancreatic juice reflux toward the biliary tree (PR) has frequently been found in subjects with common bile-pancreatic conduit (CBPC) and gallstone-induced acute pancreatitis (SAP). Our aim was to determine the role of the CBPC functional diameter as a potential trigger of PR. The CBPC was calibrated in three groups of patients: (A) patients with gallbladder stones using intraoperative direct cholangiometry (n = 24), (B) patients after surgical removal of common bile duct stones using postoperative cholangiometry via T-drain (n = 6), and (C) patients with SAP using the same procedures as in group B (n = 6). In all patients in groups B and C, aliquots of bile were collected and assayed for pancreatic amylase content. The mean functional diameter of the CBPC varied from 0.80 mm in patients in groups A and B to 0.47 mm in group C (p < 0.001). The bile samples of group B contained low concentrations of amylase, whereas high values could be found in all samples of group C. We conclude that PR is a frequent event occurring after bile duct revision concerning small amounts of pancreatic juice. However, CBPC functional stenosis as seen in patients with SAP obviously induces PR with high amounts of pancreatic juice.

Acute Disease↗

[Standardization in sigmoid diverticulitis surgery planning: indications based on evaluation with the Hughes classification].

Sigmoid diverticulitis accounts for the most frequent colonic disease in Western countries. We studied 145 patients with diverticulitis (elective resection in 105, emergency resection in 40 patients) using the HUGHES classifications-based indication of the resection procedure (Stage I, acute diverticulitis/colonic wall phlegmonia, continent resection; Stage II, perforated diverticulitis with local perotinitis, continent resection, Hartmann's procedure exceptionally; Stage III/IV, Hartmann's procedure, continent resection exceptionally). Stage-specific morbidity was I: 18%, II: 22%, III/IV: 60%; emergency case mortality was 15%; elective case mortality was 0%. Severe local failure was significantly higher in stage II/IV than stage II/I class diverticulitis. Early elective resection is recommended with regard to morbidity, mortality, and hospitalisation time and related costs.

Adult↗

[Calcium metabolism after thyroidectomy with modified radical neck dissection and parathyroid gland autotransplantation].

The issue of parathyroid autotransplantation in oncologic thyroid surgery is discussed controversially. In a series of 15 patients who underwent bilateral modified radical neck dissection for thyroid malignancy, parathyroid autotransplantation was carried out. Six months after surgery only one patient was hypoparathyroid, requiring permanent medication, thus autotransplantation is a safe procedure for the prevention of accidental hypoparathyroidism.

Adult↗