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N Segovia-Riquelme

Publications and source records attributed to N Segovia-Riquelme.

7 recordsLinked to original sources
PubMed1984

Effects of different diets on voluntary consumption of ethanol in UChA and UChB rats.

Based on the decrease of voluntary consumption of ethanol observed in rats of UChA (low ethanol consumer) and UChB (high ethanol consumer) strains, coincident to the use of a new issue of a commercial diet, the effects of two new diets devoid of animal food were studied. One of these diets (Diet 3) induced an increase of the voluntary consumption of ethanol in a proportion of UChA rats, in such a way that its frequency distribution curve resulted in a bimodal one because of the presence of individuals which drank as much alcohol as UChB rats. This diet is a useful tool for the study of eventual nutrimental factors which decrease ethanol intake.

Alcohol Drinking↗
PubMedDate not supplied

A method for recognizing specific effects on ethanol intake by experimental animals.

A method of mathematical treatment of data concerning changes in voluntary consumption of ethanol solution, water and solid food, induced by experimental treatments in animals, in order to recognize effects on mechanisms involved in specific appetite and satiety for calories, water and ethanol is proposed. The need of such method arises from the fact that several experimental treatments tested by the effects on ethanol consumption alter at the same time the appetite or satiety for calories and/or for water, as well as ingestive behavior. The results of testing the method with the data obtained by treatment of UChA and UChB rats with disulfiram or cyanamide were consistent with the expected ones.

Alcohol Drinking↗
PubMedDate not supplied

Effects of serotonin uptake blockers and of 5-hydroxytryptophan on the voluntary consumption of ethanol, water and solid food by UChA and UChB rats.

The effects of zimelidine, fluvoxamine, and citalopram (serotonin uptake blockers), as well as those of 5-hydroxytryptophan (serotonin precursor), on the voluntary consumption of 10% ethanol solution, distilled water and solid food were tested in UChA (genetically low ethanol consumer) and UChB (genetically high ethanol consumer) rats. Since it is well known that drugs which stimulate central serotonergic synapses decrease food and water intake, the data concerning the difference of the respective consumption during the treatment period and the pretreatment one were analysed with a method previously proposed (Alcohol 5:15-19; 1988) to recognize specific effects on ethanol intake. The results showed that while the decrease of ethanol consumption induced by the three serotonin uptake blockers appeared not to be specific of ethanol, the effects of 5-hydroxytryptophan in UChB rats satisfy the criteria for being considered as an expression of a decrease of the specific appetite--or increase satiety--for ethanol. Experimental results cannot help in the explanation of this difference.

5-Hydroxytryptophan↗
PubMedDate not supplied

Thirty-two years of selection of rats by ethanol preference: UChA and UChB strains.

An overview of the development of two strains of rats with low and high consumption of ethanol is reported. Voluntary consumption of water and various concentrations of ethanol solution were studied in these strains as a function of diet, supplementation with vitamin B complex components, housing conditions and coefficient of heredity. Both distribution factor of the consumption of ethanol in hybrids and the course of voluntary intake of ethanol have been described. In addition, a comparison was made between these rat strains developed for low and high preference to ethanol drinking in reference to their voluntary intake of ethanol, water and food. The metabolic concomitant to these two strains has been studied in relationship to ethanol metabolism and to other substrates, i.e., acetate, pyruvate, glucose, citrate and fructose. Behavioral studies were also performed. This included the measurements of duration of ethanol narcosis and evaluation of tolerance to ethanol drinking.

Alcohol Drinking↗