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Biomedical subjects

N Sculerati

Publications and source records attributed to N Sculerati.

23 records · Page 2Linked to original sources

Diagnostic flexible bronchoscopy in human immunodeficiency virus (HIV)-positive children.

Twelve children with laboratory evidence of human immunodeficiency virus (HIV) infection underwent diagnostic flexible bronchoscopy with washings or bronchoalveolar lavage at Bellevue Hospital Center from October 1987 to April 1989. The patients included 7 boys and 5 girls ranging from age 3.5 months to 10 years 5 months. Indications for bronchoscopy included respiratory distress with or without focal changes on chest radiograph in 11 patients, and persistent but asymptomatic right middle lobe collapse in one child. The etiology of pneumonia was diagnosed in 7 children and included Pneumocystis carinii, (PCP) (17%), Streptococcus viridans (17%), mechanical obstruction (17%) and cytomegalovirus (CMV) (8%). Bronchoscopy was non-diagnostic in 5 cases. Techniques for maximal yield of information using flexible bronchoscopy in HIV-positive children are discussed.

Bronchoalveolar Lavage Fluid↗

Pathogenesis of cholesteatoma.

Aural cholesteatomas consist of accumulations of desquamating keratinized epithelium within the middle ear or other pneumatized portion of the temporal bone. Cholesteatomas may be classified according to presumed etiology as congenital or acquired. The theoretical mechanisms of the pathogenesis of the two types are discussed.

Cholesteatoma↗

Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.

The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

Amphetamine↗

Congenital facial hemihypertrophy: report of a case with airway compromise.

Facial hemihypertrophy, first described by Beck in 1836, aroused some interest in the early part of this century among European and American clinicians. However, a search of the otolaryngologic literature failed to reveal hemihypertrophy of the head and neck area as a well-recognized entity. We recently encountered a case of hemifacial hypertrophy in a 2-year-old. The child presented with airway compromise and swallowing difficulty. The treatment of this child and a review of associated head and neck findings are discussed.

Airway Obstruction↗