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Biomedical subjects

N Schaul

Publications and source records attributed to N Schaul.

23 records · Page 2Linked to original sources
PubMed1977

Brain lesions that produce delta waves in the EEG.

Localized delta activity appears in cortex overlying a circumscribed white matter lesion. Less commonly, localized delta activity may result from a localized thalamic lesion. Unilateral diffuse delta activity appears on the side of thalamic or hypothalamic lesions. Bilateral delta activity results from bilateral lesions of the midbrain tegmentum. Localized lesions of the cerebral cortex, unilateral mesencephalic tegmental lesions, and vasogenic edema of the cerebral white matter do not produce delta activity. Marked edema of a cerebral hemisphere when no surgical decompression is provided may produce unilateral delta activity by pressure on or displacement of the brain stem or diencephalon.

Animals↗
PubMedDate not supplied

Contralateral temporal hypometabolism on positron emission tomography in temporal lobe epilepsy.

INTRODUCTION: No detailed case studies report lateralised hypometabolism on positron emission tomography (PET) contralateral to the epileptogenic focus in temporal lobe epilepsy (TLE). MATERIAL AND METHODS: We performed 18F fluorodeoxyglucose (FDG) PET in two intractable TLE patients. RESULTS: One had right temporal interictal spikes on electroencephalography (EEG) and a right medial temporal lobe lesion on magnetic resonance imaging (MRI). FDG-PET showed decreased uptake in the left temporal lobe. Right temporal ictal onset, with bilateral interictal epileptiform activity, occurred on intracranial EEG. He is seizure free after right temporal lobectomy and ganglioglioma resection. The second had right temporal lobe interictal and ictal EEG activity. MRI demonstrated right anteriomedial temporal increased T2 signal. Neuropsychology revealed bilateral cognitive dysfunction. FDG-PET showed left anterior temporal and lateral frontal hypometabolism. He is seizure free after right temporal lobectomy. CONCLUSION: These findings suggest that regional uptake asymmetry on FDG-PET may be give misleading lateralising information in TLE.

Adult↗
PubMedDate not supplied

Three-dimensional fast low-angle shot imaging and computerized volume measurement of the hippocampus in patients with chronic epilepsy of the temporal lobe.

This study investigated the use of three-dimensional fast low-angle shot (FLASH) imaging and computer-assisted morphometry for identifying hippocampal changes associated with unilateral temporal lobe seizures. Contiguous 3.1-mm coronal FLASH images were obtained in 28 patients with electroencephalographically verified left (n = 17) or right (n = 11) temporal lobe seizures and 28 age- and sex-matched control subjects. Hippocampal volumes were calculated with the use of a computerized mensuration system developed for detailed morphometric assessment. The results of a multivariate analysis of variance revealed a significant group difference by hemisphere interaction (F = 26.3, p less than .001). Significant reductions in left hippocampal volume (32%, p less than .001) were exhibited in patients with left temporal lobe seizures, and significant reductions in right hippocampal volume (35%, p less than .001) were seen in patients with right temporal lobe seizures. A discriminant analysis with the use of left and right hippocampal volumes classified patients with left temporal lobe seizures with 94% sensitivity and 73% specificity and patients with right temporal lobe seizures with 89% sensitivity and 94% specificity. The results of this study demonstrate that unilateral temporal lobe seizures are accompanied by significant reductions in hippocampal volume ipsilateral to the seizure focus. The use of FLASH imaging and computer-assisted morphometry of the hippocampus appears to provide valuable structural information for confirming the laterality of the electroencephalographic seizure focus.

Adolescent↗