Search PubMed⌕ Search

Biomedical subjects

N Schaub

Publications and source records attributed to N Schaub.

25 records · Page 2Linked to original sources
PubMed1985

[Ischemic colitis as a cause of intestinal bleeding after marathon running].

A 33-year-old long-distance runner had three episodes of bloody diarrhoea, all occurring after competitive marathon runs. Colonoscopy revealed a small lesion in the caecum histologically compatible with ischaemia of the mucosa. The discussion centres on the pathophysiology of impaired intestinal blood supply during excessive effort and the frequency of gastrointestinal symptoms and occult blood loss due to jogging.

Adult↗
PubMed1985

[Pathogenesis of gastroesophageal reflux].

Gastro-oesophageal reflux (GOR) is common. Nearly all healthy individuals experience occasional or frequent reflux episodes, with or without symptoms, which occur during spontaneous relaxations of the lower oesophageal sphincter, predominantly after meals. It is not known how neural, hormonal and muscular factors contribute to this. A proportion of the patients with reflux disease have normal lower oesophageal sphincter pressures, and their reflux episodes occur during spontaneous sphincter relaxations following the pattern of normals. Nevertheless, most patients with reflux disease have decreased lower oesophageal sphincter pressure, and manoeuvres which increase the intraabdominal pressure provoke "stress" reflux. If the sphincter pressure is very low, "free" reflux occurs; the cause of decreased sphincter pressure is not known. Pharmacological and gastric factors also facilitate GOR. The noxious potency of reflux material on the oesophageal epithelium depends on its components [( H+], pepsin, bile salts, trypsin) and the contact time, which is prolonged during supine and nocturnal reflux episodes, i.e. when clearance function is impaired. In complicated reflux disease it is necessary to consider this multifactorial model of the pathogenesis of reflux disease, and to go on to more sophisticated diagnostic procedures (manometry, scintiscanning, prolonged pH-monitoring) in order to identify an individual patients' predominant pathogenetic factor.

Cholecystokinin↗
PubMed1981

[Atrioventricular block after carotid pressure in hypothyroidism: normalisation after substitution treatment (author's transl)].

Severe auto-immune hypothyroidism, probably after hyperthyroidism, was diagnosed in a 79-year-old woman with hypothyroidism (T3 and T4 immeasurably low) without the classical signs of myxoedema heart. On carotid sinus pressure transitory first degree AV block occurred and, on one occasion, complete AV block. This response disappeared after substitution treatment for four weeks with 50 microgram L-thyroxine. Further examination half a year later, on a maintenance of 75 microgram thyroxine, also gave a negative response to carotid sinus pressure.

Aged↗
PubMed1975

[Incidence of postoperative deep vein thrombosis in general surgical and urological patients an investigation by means of the 125I-Fibrinogen test in 95 patients withoug prophylaxis (author's transl)].

We present the results of a control group of 95 patients who were thoroughly investigated in a prospective, randomized study, where the efficacy of small doses of s.c. heparin and dextran 40 is checked. The 125I-fibrogen test was used in all patients. 1. 35.8% of the patients develop deep vein thrombosis (DVT) during the first post-operative week. More than half of them show bilateral thrombosis. 2. There is no statistically significant difference in the thrombosis incidence between males and females. 3. 47% of the patients over 60 years develop postoperative DVT. Among those younger than 60 years, only 23% have DVT (P less than 0.025). 4. The DVT incidence in surgery of the colon is 58.3%. 5. Surgery for a malignant disease means probably increased risk for DVT (P less than 0.025). 6. More than half of the patients having a previous history of varicose veins develop postoperative DVT (P less than 0.025). 7. Obese patients are statistically seen not more prone to develop DVT than those of normal body build. 8. Immediately after operation 32.4% of DVT are diagnosed, 24 hrs. later 61.8%. 94% of all DVT are diagnosed up to the third postoperative day. 9. With the exeption of one patient, all DVT develop in the calf veins, 3/4 of all abnormal values were measured in the midcalf region.

Adult↗