Search PubMed⌕ Search

Biomedical subjects

N Sawabu

Publications and source records attributed to N Sawabu.

At least 145 records · Page 8Linked to original sources
PubMed1983

[Tumor markers of hepatocellular carcinoma with special reference to diagnostic efficacy of combination of these markers and relation to its stages].

The authors concurrently determined four markers consisting of novel gamma-GTP isoenzyme (Novel gamma-GTP), variant alkaline phosphatase (VAALP), basic fetoprotein (BFP) and CEA in addition to AFP in 144 patients having HCC. Serum AFP levels below 400ng/ml, a condition commonly seen in sera of hepatobiliary diseases other than HCC were obtained in 60 our of patients, or 42%. There was little correlation among positivities of these markers, and the diagnostic usefulness was increased by combination assay of these markers, except in the case of CEA. Specific diagnosis of HCC could be made in 78% by a combination of Novel gamma-GTP and VAALP in addition to AFP. Moreover, diagnosis of an existing malignancy could be made in 87% by BFP in addition to AFP, Novel gamma-GTP and VAALP. Positive ratios of BFP and CEA increased in proportion to staging, whereas those of AFP and Novel gamma-GTP were independent of the stage and relatively high even in patients within the early stage. In general, incidences of these markers were relatively lower in patients having small HCC, however, markers of a secreting type such as AFP and Novel gamma-GTP were relatively useful for early diagnosis of HCC.

Alkaline Phosphatase↗
PubMed1980

Novel gamma-GTP isoenzyme as diagnostic tool for hepatocellular carcinoma.

Out of 13 bands of gamma-GTP isoenzymes which were separated by our method, band II, II' and I' were specifically found in sera of patients with hepatocellular carcinoma (HCC), and therefore were called HCC specific novel gamma-GTP isoenzyme (novel gamma-GTP). One or more of these bands were detectable in 95 out of 178 patients with HCC. The positive ratio of novel gamma-GTP was 53% in total patients of HCC, and corresponded to 71% in patients whose serum activity of gamma-GTP was more than 100 mu/ml. In general, there was significant correlation between positivity of the novel gamma-GTP and titer of AFP. However, it was found in 33% of patients with AFP levels below 400 ng/ml which were frequently encountered in liver diseases other than HCC. From these results novel gamma-GTP can be useful also in diagnosis of HCC patients in whom serum AFP is lower or negative.

Carcinoma, Hepatocellular↗
PubMed1975

A case of watery diarrhea, hypokalemia and hypercalcemia associated with nonulcerogenic islet cell tumor of the pancreas.

A case of watery diarrhea, hypokalemia and hypercalcemia associated with an islet cell tumor was described. A 62-year old man exhibited frequent watery diarrhea and hypokalemia for two years. He had no peptic ulcer and serum gastrin level was normal. His serum calcium was abnormally high and serum phosphate was lowered. He had secretin-like activity in his plasma. Autopsy revealed a small islet cell tumor in the pancreas and several metastatic masses in the liver. Microscopic examination revealed the tumor cell was not beta, alpha nor D cells. By electron microscopy the secretion granules of the tumor cell resembled those of S, M and T cells. It was not possible to decide which of the tree cell types was responsible for the pancreatic cholera.

Adenoma, Islet Cell↗