Tracheal allogenic immunoresponse is reduced by cryopreservation: canine experiment.
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Animals↗
Biomedical subjects
N Sawabata
Publications and source records attributed to N Sawabata.
[A case of mucoepidermoid carcinoma of the thymus].
A 19-year-old man was admitted to our hospital with anterior mediastinal cystic tumor. Subtotal thymectomy with the tumor was performed. The tumor was localized inside the thymus without outer infiltration. It weighed 145 g and measured 9 x 8 x 5 cm. The cut surface was cystic and spongy, partially with a solid focus. Pathological findings of the solid area was compatible with mucoepidermoid carcinoma of the thymus. The histogenesis of mucoepidermoid carcinoma of the thymus was discussed.
Adult↗
Flow cytometric analysis of the DNA content of thymomas.
In this study, the prognostic value of determining the nuclear DNA content of thymomas by flow cytometry was evaluated. Of a total 31 resected thymomas, 10 (32%) showed DNA aneuploidy, the presence of which was significantly correlated with an advanced clinical stage of disease. The patients with an aneuploid tumor had a poorer prognosis than those with a diploid tumor, demonstrating a survival rate of 50% at 7 postoperative years, which was considerably less favorable than that of the patients with a diploid tumor, being 100% in the same period (p < 0.05). Moreover, patients with a high DNA index (DI), i.e., a DI >or= 1.5, tended to have a poorer prognosis than those with a low DI. These findings indicated that the DNA content can be an important prognostic index in patients with thymomas.
Adult↗
Solitary lymphangioma of the lung.
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Child↗
[Morphological examination of the lung tissue ablated with Nd;YAG laser in the treatment of bullous pulmonary disease].
We conducted a morphologic examination of ablated pleurae and bullae to assess the efficacy of Nd;YAG laser irradiation to the lung tissue for the treatment of bullous pulmonary disease. Pleurae and bullae from surgically resected lung tissue to treat pulmonary carcinoma were ablated using a Nd;YAG laser at a power of 10 watts and 1.5 seconds within a 1-centimeter-diameter circle (about 0.2 joule/cm2). Samples were analyzed by light microscopy and scanning electron microscopy. Nd;YAG laser irradiation caused elastic fiber-contraction and gel from collagen both in pleurae irradiated once and in bullae irradiated three times. We conclude that Nd;YAG laser irradiation can be applied to ablate pleurae and bullae into a tight and continuous structure which is important in preventing air leak from the pulmonary parenchyma.
Emphysema↗
Angiographic demonstration of no-flow anatomical patency of internal thoracic-coronary artery bypass grafts.
To clarify the no-flow situation of the stringlike internal thoracic artery graft, we angiographically examined such grafts by temporarily occluding the recipient coronary artery with a percutaneous transluminal coronary angioplasty balloon and were able to reveal anatomical patency of the internal thoracic artery graft in 2 patients 1 year and 3 years after the operations. Thus, there is a possibility that internal thoracic artery grafts may continuously maintain anatomical patency even under no-flow situations just like nonfunctioning collateral vessels and may function properly later as a graft when the native coronary flow decreases. Also, this angiographic technique can be a new method for detecting anatomical patency of no-flow and functionally closed internal thoracic artery grafts.
Anastomosis, Surgical↗
Protection against lipid peroxidation induced during preservation of lungs for transplantation.
The questions of whether oxygen-derived free radicals are induced during preservation of lungs and, if so, how such radicals might relate to reperfusion injury were investigated by means of an isolated canine lung model. Lungs were obtained from 16 mongrel dogs and divided into groups 1 (n = 6), 2 (n = 5), and 3 (n = 5). The lungs of groups 1, 2, and 3 were flushed through the pulmonary artery with Euro-Collins solution alone, the solution with superoxide dismutase (120,000 U/L), and the solution with allopurinol (1 mmol/L), respectively, at 4 degrees C and then stored for 4 hours in the respective solutions at 4 degrees C with clamped bronchi. They were then reperfused for 2 hours by means of an isolated lung model. Lung lipid peroxidation was sequentially determined. The lung functional status was assessed by systolic pulmonary arterial pressure and end-inspiratory airway pressure. The lung edema was assessed by lung wet/dry weight ratio. Lipid peroxidation was induced after 1 hour of preservation and the first 30 minutes of the reperfusion in group 1 and only 2 hours of the reperfusion in group 2, whereas no induction was observed in group 3. Values for systolic pulmonary arterial pressure and end-inspiratory pressure in group 1 were significantly higher than those in group 3 (p < 0.05). The lung wet/dry weight ratio in group 1 was significantly higher than that in groups 2 and 3 (p < 0.05). The present results indicate that the administration of free radical scavengers in the preservation may effectively improve conditions for lung transplantation.
Airway Resistance↗