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Biomedical subjects

N Sasano

Publications and source records attributed to N Sasano.

At least 127 records · Page 7Linked to original sources
PubMed1978

Autopsy findings in a case of acute paraquat poisoning with extensive cerebral purpura.

An autopsy case of paraquat poisoning in an adult male died on the 6th day of intoxication was presented. Histological and electron microscopic observations demonstrated interstitial pneumonia with distinct interstitial fibrosis and the initial stage of alveolar fibrosis with coexisting edema and hyaline membrane formation. Striking hemorrhagic leukoencephalopathy, i.e. 'purpura cerebri,' was noted throughout the central nervous system involving almost exclusively the white matter. It consisted of focal hemorrhages of various stages accompanied by demyelinating processes of various extent. Globular and/or amorphous proteinaceous materials of uncertain nature were demonstrated in the vascular lumina throughout the brain.

Adult↗
PubMed1976

Polyps and diverticulosis of large bowel in autopsy population of Akita prefecture, compared with Miyagi. High risk for colorectal cancer in Japan.

A necropsy study of polypoid lesions and diverticula of the large bowel in the Japanese prefectures of Akita and Miyagi indicated that adenomatous polyps were more numerous in Akita (30%) than Miyagi (18.3%). They also were larger and showed more severe atypia in Akita. The sigmoid colon and rectum showed the most severe atypia in both prefectures. Hyperplastic polyps and diverticula were very uncommon in both prefectures. These results are discussed in relation to the different levels of risk to colorectal carcinoma in these prefectures and in Japanese migrants to Hawaii.

Adolescent↗
PubMed1976

Histopathological studies on intrahepatic bile ducts in the vicinity of porta hepatis in biliary atresia.

Intrahepatic bile ducts in the vicinity of the porta hepatis were histologically investigated in 9 cases of biliary atresia and the pattern of bile duct was divided into two groups. In the first group, there were a few large bile ducts which had continuity to the extrahepatic bile duct. In the second group, many small bile ducts were histologically observed, but there was no large bile duct at the porta hepatis. This type of abnormal bile ducts was seen in the cases of obliteration of bile ducts at porta hepatis.

Bile Ducts↗
PubMed1976

Comparative studies on dysplasia of esophageal epithelium in four prefectures of Japan (Miyagi, Nara, Wakayama and Aomori) with reference to risk of carcinoma.

Distal two-thirds of the esophagus without macroscopically detectable malignant lesions from a total of 248 autopsy cases were examined for epithelial dysplasia on histological sections from serial blocks. The autopsy specimens had been obtained from Miyagi. Nara and Wakayama prefectures known for high incidence of esophageal carcinoma in Japan, and Aomori prefecture where the incidence of the disease is low. Epithelial dysplasia was classified into mild, moderate, and severe including carcinoma in situ according to the grade of epithelial atypism. Of 248 cases 91 (36.7%) had epithelial dysplasia and 30 (12.1%) had moderate and severe dysplasia. In one of the cases of severe dysplasia, in situ carcinoma was diagnosed. Lesions of dysplasia of the resected specimen were displayed in a diagram for the distribution of the abnormal epithelium. Cases of higher grade dysplasia tended more extensive in area and were slightly dominant in the distal third of the esophagus. Possible relationships of dysplasia with long-standing irritation to the esophagus and with precancerous lesions were discussed.

Adult↗
PubMed1975

Reconstruction of intrahepatic bile ducts in congenital biliary atresia.

Macroserial reconstruction of the main intralobular bile ducts was made in 7 cases of biliary atresia; 2 cases of type I, 1 case of type II and 4 cases of type III according to Kasai's classification. From the results of these reconstruction studies, it was confirmed that the main interlobular bile ducts are usually patent through the liver regardless of the type of atresia of the extrahepatic bile ducts. A microserial reconstruction of bile ducts and ductules of a small portal tract performed in one case disclosed that a number of ductules make a network around the main duct and have some communications with the main duct. These results were compatible with the fact that active excretion of bile was obtained in many postoperative patients with biliary atresia. As observed in one case of the present series, postoperative complication of severe ascending cholangitis seemed to be an important cause of destruction or disappearance of intrahepatic bile ducts, which has also seen in older infants with this disease without complicaion of cholangitis. In view of these facts the operation of an early stage of life is recommended in biliary atresia.

Autopsy↗
PubMed1975

Consecutive radiography of breast slices for estimation of glandular volume and detection of small subclinical lesions. A comparison between Japan and Hawaii Japanese.

A technique of consecutive radiography of the serially sliced breast was evolved and applied to a comparative study on the breast of Japanese in Japan (75 subjects) and Hawaii (49). Increased mammary fat accounts for an increase in the size of the Hawaii Japanese breast (mean; 152.4 cm3) in comparison with that in Japan (82.5 cm3). However, the glandular volume calculated from the radiography and lobular structures in histology were not significantly different in the two groups. A small subclinical lesion measuring over 3 mm in diameter in a histological section was radiographically detected. In Hawaii, duct-epithelial hyperplasia and apocrine metaplasia were significantly more prevalent in Japan, and the former lesion was most conspicuous in the large mammary gland.

Adult↗