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Biomedical subjects

N Sansoy

Publications and source records attributed to N Sansoy.

11 recordsLinked to original sources
PubMed1993

Ocular involvement in two symptomatic congenital erythropoietic porphyria.

Congenital erythropoietic porphyria (Gunther disease, CEP) is a rare autosomal recessive disorder of haeme biosynthesis. It is characterized by extreme photosensitivity and the excretion of large amounts of uroporphyrin I and coproporphyrin I in the urine and coproporphyrin I in the faeces. We have diagnosed two cases of congenital erythropoietic porphyria, who were first cousins once removed. They had recurrent skin bullae, scarring on the face and hands, hirsutism, discoloured fluorescent teeth, red urine, increased haemolysis and grossly increased excretion of porphyrin. Both children had blepharitis and their sclera gave pink fluorescence under long wave ultraviolet light, mainly in the interpalpebral fissures. All the features of our two patients, except the ocular lesions, conformed to cases of CEP reported in the literature. We have encountered no other reports on ocular lesions in CEP since first described by Chumbley in 1977.

Adolescent↗
PubMed1990

Measurement of cardiac output by the thermodilution method during left thoracotomy in the lateral position in the dog.

The validity of cardiac output measurement by thermodilution in the lateral position during thoracotomy was assessed. Three balloon thermodilution Swan-Ganz catheters were placed in the pulmonary artery trunk and the right and left pulmonary arteries in 12 mongrel dogs, after left thoracotomy had been performed. Cardiac output was measured simultaneously from two of the three sites. The cardiac output measurements show no significant difference related to the location of the catheter extremities: the mean cardiac index was found to be 2.164 +/- 0.448 l/min/m2 from the pulmonary artery trunk, 2.127 +/- 0.404 l/min/m2 from the left branch and 2.116 +/- 0.421 l/min/m2 from the right branch. It is concluded that the measurement of cardiac output during left thoracotomy is valid, whether the thermistor is situated in the pulmonary artery trunk or in a main branch to either the dependent or non-dependent lung.

Animals↗
PubMed1980

[Current data on pain mechanisms (author's transl)].

Nocicepives messages are vehiculated mostly by the A delta and the C fibres, but not exclusively. Spinal cords cells of layers I and V play a very important role in the transmission of painful messages. Spinothalamic pathways include numerous projections among the reticular formation and the mid-brain. This allows the convergence of miscellaneous informations and creates marrow bonds with the structures implicated in comportmental aspects, such as the hypothalamus and the rhinencephalon. Painful message is under the influence of several controls, permanently. There is a metameric control multisegmental; there is a supremetameric one, the raphe nuclei form the essential stake. The discovery of stereospecific sites for the binding of opiates, led to the discovery of the endogenous opiate peptides. These may act as neuromodulators, specifically at the level of the dorsal-horn. Morphine seems to act like them, re-enforcing the physiological mechanism. Biogenic amines such as serotonin are implicated in the regulation of the painful message.

Humans↗
PubMedDate not supplied

Corneal sensitivity after penetrating keratoplasty.

In order to determine corneal sensitivity after penetrating keratoplasty, 71 corneal transplants and their recipient beds were tested using the Cochet-Bonnet esthesiometer. The periods from surgery to examination were two weeks to 15 years. When the test results were divided into six groups according to the postoperative period, correlation analysis revealed a progressive improvement of sensitivity in the central and peripheral graft as well as in the recipient cornea. Only one graft had normal central sensitivity at 24 months; 36 grafts were completely anesthetic while 35 grafts had some level of sensitivity at the time of last clinical testing. Age, preoperative diagnosis or graft size were not correlated with the recovery of sensitivity. The extent and time of reinnervation in corneal grafts varied in individual patients.

Adolescent↗