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Biomedical subjects

N Sakurada

Publications and source records attributed to N Sakurada.

At least 37 records · Page 2Linked to original sources
PubMed1982

[The relationship between the number of anti-thyroglobulin antibody forming cells from the cultured peripheral lymphocytes and the serum antibody titers in patients with chronic thyroiditis (author's transl)].

Anti-thyroglobulin antibody forming cells (AFC) were generated from the cultured peripheral lymphocytes of patients with chronic thyroiditis. In order to clarify whether this reflects the antibody formation in vivo, the number of antibody forming cells generated in the culture was related to the serum antibody titer in 121 cases. There was no case which produced more than 10 AFC from 2 x 10(5) B-cells in the group with the low serum antibody titer (less than 10(2)), while 29.4% produced more than 10 AFC in the patients with antibody titer of 20(2) and 20(4) and 65.2% in the group with titer of 80(2) approximately 640(2). The average number of AFC of the last group was 31.4 +/- 17.7 (SD). AFC and serum antibody titers were estimated on various occasions with the same patients. A good relationship was observed between these two parameters. There was no significant correlation between the numbers of AFC and serum antimicrosome antibody titers.

Adolescent↗
PubMed1981

Increased renal kallikrein excretion in SIADH after vincristine therapy.

This is a report about a 14-year old girl who, following chemotherapy for malignant teratoma, developed a clinical state of SIADH (syndrome of inappropriate secretion of antidiuretic hormone). The causative agent was most likely vincristine (VCR). The important feature in this case was that the urinary kallikrein activity was high when she was affected by SIADH and decreased when her hyponatremia improved. Sodium clearance was significantly correlated with the increase in urinary kallikrein activity. It is considered that the kallikrein-kinin system may in part participate in the excessive natriuresis of SIADH.

Adolescent↗
PubMed1979

Evaluation of cytological examination by aspiration biopsy for the diagnosis of chronic thyroiditis in childhood.

To evaluate the diagnostic value of cytological study of the goiter in pediatric practice, percutaneous aspiration biopsies were performed on 22 patients. In 13 of 14 patients whose physical and serological examinations suggested chronic thyroiditis, abundant lymphoid cells including germinoblasts and germinocytes were observed in the smeared preparation of aspirated materials. A few degenerated follicular epithelial cells, reticuloendothelial cells, and plasma cells were also occasionally seen. No fibrous clements were observed. In 5 of 8 patients with simple goiter, only a few intact follicular epithelial cells were seen. The procedure was simple, well tolerated by the patients, and there were no complications. Based on these results, it was concluded that percutaneous aspiration biopsy may be one of the useful methods for the diagnosis of chronic thyroiditis in childhood.

Adolescent↗
PubMed1974

[Neonatal goiter].

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Congenital Hypothyroidism↗