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Biomedical subjects

N Sakabe

Publications and source records attributed to N Sakabe.

9 recordsLinked to original sources
PubMed1979

Crystallization and preliminary crystallographic data of chicken gizzard G-actin . DNase I complex and Physarum G-actin . DNase I complex.

Smooth muscle G-actin from chicken gizzard and Physarum plasmodium G-actin both interact with DNase I and form 1 : 1 complexes. These complexes were crystallized by using polyethylene glycol 6000 as a precipitant. Both crystals belong to the same orthorhombic space group P2(1)2(1)2(1). The cell dimensions of chicken gizzard G-actin.DNase I complex are a=42.00 +/- 0.07 A, b=225.3 +/- 0.4 A, and c=77.4 +/- 0.1 A, while those of Physarum G-actin.DNase I complex are a=42 A, b=221 A, and c=77 A.

Actins↗
PubMed1978

Modification and application of the computerized automatic audiometer.

Recently, medical information processing systems applying computers have achieved marked advances in parallel with the development of highly accurate automatic measuring instruments. The authors already in 1974 developed and reported a computerized automatic audiometer containing a micro-computer which stored a program for audiometric procedures. Subsequently the authors have developed a compact, multi-purpose audiometric instrument which executes the standard air-bone conduction audiometry, with the exclusion of masking, automatically with a built-in micro-computer. An outline of the instrument is as follows: 1. The instrument is composed of a memory, a control unit, programs for data processing and measurement, a character display for instructing subjects and an audiogram display. It can be operated manually in the same way as a conventional audiometer. 2. Test errors and any abnormally large differences between the responses of the two ears can be detected automatically, and the tests can then be re-executed manually after finishing the automatic procedure for correction of the data. 3. The instrument is provided with output terminals for connection to an external computer or other peripheral equipment. It is designed to be compact and light weight.

Adult↗
PubMed1978

Development of an audiometry data processing system.

The development was reported of an electronic data processing system of computerized automatic audiometry and of Bekesy audiometry. This system using a microcomputer has the following features: (1) The large amount of data obtained through (a) automatic audiometry, (b) Bekesy audiometry (measurement at fixed or continuous frequency plus test practice, and (c) the Temporal Tone-Decay test can be stored on-line in real time, and are processed and displayed off-line at any time. (2) When retrieved, the output format of these audiometric data is of the same pattern as the conventional audiogram. (3) The output pattern on the CRT graphic display can be hard-copied whenever desired. (4) The system can be operated manually in the same way as the conventional method. (5) The SISI and DL tests can be executed manually and the resultant data keyed into computer storage. And (6) The operation from the data input to the retrieval output is performed interpretively through the CRT display, so that anyone even without special computer or audiological training can operate it at any time.

Audiometry↗
PubMedDate not supplied

Reliability and validity of late vertex-evoked response audiometry.

In order to evaluate the current visual scoring technique in the late vertex-evoked response audiometry (ERA), the detectability of the response, errors in judgment, consistency between scorers and test-retest reliability were studied in adults and young children in waking and sleeping states. In waking adults, ERA proved to be a quite reliable and valid method for testing hearing objectively. On the contrary, a marked inconsistency was found in the appearance of the response in children during sleep. From a clinical standpoint, ERA in waking adults and sleeping children should be regarded as two substantially different methods.

Acoustic Stimulation↗
PubMedDate not supplied

Power spectral analysis of auditory evoked response.

Five normal hearing adults were examined for power spectral analysis of AER to 1000-Hz pure tone. Major frequency components of responses to stimuli at 50 dB hearing level exist at 1 to 14 c/s. The power spectra of responses to stimuli at 10 dB hearing level are greater than those of the SBA in the frequency components between 3 and 9 c/s; furthermore, the total power of 3 to 9 c/s indicates a clear difference between the 2. Incidentally, at 512-msec analysis time, the total power of 3 to 9 c/s of the AER are significantly greater than that at 1024-msec analysis time, whereas those of the SBA show little discrepancy at the 2; thus at 512-msec analysis time, the total power of 4 to 9 c/s yields a clear difference between the AER and the SBA responses averaged over 50 stimuli even at 10 dB hearing level.

Adult↗