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Biomedical subjects

N Saha

Publications and source records attributed to N Saha.

At least 199 records · Page 11Linked to original sources
PubMed1981

Energy balance study in pregnant Asian women.

Twenty-four pregnant Asian women resident in Singapore were tested for the determination of energy cost of rest and various common daily activities. The average daily energy expenditure was estimated from a diary of activities of seven days. The average daily energy intake was computed from Food Tables on the basis of consumption of measured dressed raw materials of food over seven days in the same period of measurement of energy expenditure. The average daily energy intake and expenditure in this group of pregnant women were found to be 2020 and 1810 kcal (8.5 and 7.6 MJ) giving a balance of +210 kcal (0.9 MJ) per day.

Energy Intake↗
PubMed1980

Some blood genetic markers of selected tribes in Western Saudi Arabia.

A total of 292 randomly selected subjects belonging to two indigenous Arab tribes (Harbi and Ghamid) and two immigrant tribes (Mograbi and Mowallad), residents in Western Saudi Arabia, have been tested for genetic variants of six blood groups, four serum proteins, and five red cell enzyme systems. The distribution of the polymorphic systems was different between indigenous and immigrant tribes, and the present Arab population shows a considerable degree of admixture from the surrounding countries, in particular Africa.

Blood Group Antigens↗
PubMed1980

Blood protein polymorphism in the one-humped camel (Camelus dromedarius) in the Sudan.

The blood protein polymorphism of serum albumin, haptoglobin, transferrin, ceruloplasmin and haemoglobin have been studied in 135 samples from one-humped Arabian camel (Camelus dromedarius) of the Sudan by starch gel electrophoresis. Only the serum albumin and haptoglobin systems exhibited polymorphism with the estimated frequencies of 0.0222, 0.2227 and 0.7773 for Albv, Hp1 and Hp2 respectively. The frequency of Hp0 was 0.0325. No electrophoretic variant was observed at transferrin, ceruloplasmin and haemoglobin loci in the camel. The activity of the ceruloplasmin of the camel sera was weak.

Animals↗
PubMed1980

Genetic association in vitiligo: ABO, MNSs, Rhesus, Kell and Duffy blood groups.

One hundred and seventy Sudanese patients suffering from vitiligo were investigated for the distribution of A1A2BO, MNSs, Rhesus (genotypes), Kell and Duffy blood groups. The same genetic markers were investigated in Sudanese controls, consisting of two series: a published population series and a random sample of healthy blood donors. The relative frequencies of these blood groups were examined between the vitiligo patients and either or both of the control series. There was no significant association of ABO, Ss, Rhesus, Kell and Duffy blood groups in vitiligo. However, a significant association was observed with the MN system with an excess of homozygotes and of the M gene in vitiligo.

ABO Blood-Group System↗
PubMed1980

Mitochondrial malic enzyme polymorphism in an Indian population.

Mitochondrial malic enzyme (MEM) was examined by starch-gel electrophoresis in 182 brain samples from 102 male and 62 female subjects of Indian origin in Calcutta, Eastern India. The estimated gene frequencies of MEM were 0.56 for MEM1 and 0.44 for MEM2 in this population. There was no difference in gene frequency between the sexes. No deviation from the Hardy-Weinberg equilibrium was observed. MES did not show any polymorphism.

Brain↗
PubMed1979

Association of glucose-6-phosphate dehydrogenase deficiency with diabetes mellitus in ethnic groups of Singapore.

Six hundred and nine male patients suffering from maturity onset diabetes mellitus, comprising 422 Chinese, 66 Malays, and 121 Indians, were investigated to determine the incidence of G6PD deficiency, ABO blood groups, and haemoglobin types, and these were compared with normal healthy controls. A positive association with a higher incidence of G6PD deficiency in diabetics was observed in Chinese and Indian patients. There was no significant difference in the frequencies of ABO blood groups and haemoglobin types between the patients and the controls in any of the ethnic groups studied.

ABO Blood-Group System↗
PubMed1979

Haemoglobin and erythrocytic glucose-6-phosphate dehydrogenase variants among selected tribes in Western Saudi Arabia.

638 subjects from six tribes in Western Saudi Arabia were tested for haemoglobin and G-6-PD variants. In the bedouins of Harbi and Sahafi tribes there was no sickling but a low frequency of both G-6-PD deficiency (1.7%) and the Gd A+ variant (1.7%) in Harbi. In Mograbi and Mowallad tribes who immigrated recently from Africa, the frequency of Hb S was 4.1 and 3.5%, G-6-PD deficiency 7.5 and 8.5% and the Gd A+ variant 15.1 and 8.5% respectively, which are higher than in bedouins. In Ghamid tribe 4% had Hb S and there was a low frequency of both G-6-PD deficiency (4.8%) and Gd A+ variant (1.6%). However a new B slow variant is common among the Ghamid (16.1%). Hb S frequency in Zahran tribe was 2.6%. Six of the 12 g-6-PD deficient (screening) were found to be positive on starch gel electrophoresis.

Erythrocytes↗
PubMed1978

A study of some genetic characteristics of the population of the Sudan.

300 random blood samples collected from residents of Khartoum, Sudan, were analysed for 5 blood group systems, 4 serum proteins, 9 red cell enzymes, abnormal haemoglobins and beta-thalassaemia. The results suggest varying degrees of admixture of the local tribes by migration from the surrounding regions. Two samples showed a probable new variant of glucose 6-phosphate dehydrogenase (? GdB Khartoum) with normal red cell activity. In spite of the presence of a high degree of consanguinity in the population, there was no significant deviation from Hardy-Weinberg equilibrium in any of the polymorphic systems.

Blood Group Antigens↗
PubMed1978

A population genetic study of the Vania Soni in Western India.

A total of 267 blood samples from persons belonging to the Shrimali Vania Soni caste group in Gujarat State, Western India have been analyzed for 6 blood group, 4 serum protein and 19 red cell enzyme systems, for haemoglobin and beta-thalassaemia and for red-green colour blindness. A number of rare genetic variants were detected, including a unique electrophoretically fast variant of superoxide dismutase. Genetic distance comparisons with other caste groups in Gujarat State show that Vania Soni from Surat are a distinctive group clustering with another subdivision of the Vania. The remaining Vania Soni cluster together and are distinct from the other caste groups examined in Gujarat. However, on the basis of individual genetic markers the Vania Soni appear not to be genetically differentiated in any remarkable way from other Hindu populations in western and northern India.

Blood Group Antigens↗
PubMed1978

Further data on mitochondrial malic enzyme in man.

Mitochondrial malic enzyme was examined by starch-gel electrophoresis in human brain samples from 291 adults and 118 fetuses, all of European origin. Gene frequencies were estimated as MEM10.65 and MEM20.35. There was no significant difference in phenotype distribution between the sexes nor between adults and fetuses. No deviation from Hardy-Weinberg equilibrium was found. Malic enzyme was examined in various other tissues and although strongest in brain, it was also frequently active in adult testis, heart and kidney. An additional isozyme migrating less anodally than mitochondrial malic enzyme and especially prominent in heart muscle was found to be attributable to a combination of aconitase and isocitrate dehydrogenase acting on citrate in the gel buffer.

Adult↗
PubMed1976

Characterization and tissue distribution of N-acetyl hexosaminidase C: suggestive evidence for a separate hexosaminidase locus.

1. An electrophoretic system in which N-acetyl hexosaminidase C (HEX(C)) MIGRATES LESS ANODALLY THAN N-acetyl hexosaminidase A (HEX(A)) is described. 2. HEX(C) is shown to differ from HEX(A) and HEX(B) in substrate specificity, molecular size and affinity for Concanavalin-A. 3. HEX(C) is present in a wide range of adult and foetal tissues and in tissues from patients with Tay-Sachs and Sandhoff's diseases. It is particularly prominent in brain, testis, thymus and lymphoblastoid cell extracts and in several foetal tissues. 4. It is suggested that HEX(C) is coded at a separate gene locus from HEX(A) and HEX(B).

Acetylglucosaminidase↗
PubMed1976

Population genetic studies in kerala and the nilgiris (South West India).

A total of nearly 1,000 persons belonging to a number of caste, religious and tribal groupings in Kerala and the Nilgiri Hills of South India have been tested for genetic variation in 4 blood group, 5 serum protein and 17 enzyme systems as well as haemoglobin. The distribution of blood groups, serum protein and enzyme groups is similar to that reported for other South Indian populations. Abnormal haemoglobins were detected in several populations. Abnormal haemoglobins were detected in several populations, HbS being present in more than 20% of the Irula and Kurumba in the Nilgiri Hills. In the Kerala populations there were 4 examples of Hb AD and 1 of Hb AE. Genetic distance estimates using the gene frequency data indicate that the closest groups are the Nayar and Izhava and the Brahmin and Nayar. The tribal populations are approximately twice as far from the Nayar as they are from the Izhava. The Todas of the Nilgiri Hills are somewhat closer to the Brahmin of Kerala than they are to the other tribal populations.

ABO Blood-Group System↗