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Biomedical subjects

N S Smith

Publications and source records attributed to N S Smith.

11 recordsLinked to original sources
PubMed1994

Applying population-based case mix adjustment in managed care: the Johns Hopkins Ambulatory Care Group system.

When analyzing medical utilization or other health care-related measurements across provider panels, case mix adjustment is required because "illness burden" is often unevenly distributed across these patient populations. This article develops the rationale for case mix adjustment and walks readers through the case mix adjustment process using the Johns Hopkins Ambulatory Care Group (ACG) Case-Mix System as a model. The ACG system is a population-oriented patient classification tool based on diagnoses assigned by providers and found in payors' data systems. The system categorizes patients according to illness burden. It does not categorize visits, encounters, or episodes. ACGs adjust for case mix differences in the analysis of ambulatory, laboratory, pharmacy, and total health care service delivery.

Ambulatory Care↗
PubMed1978

Bleomycin (review).

Since the original observation and description of the various forms of Bleomycin (BLM), numerous articles have appeared dealing with the activity on mammalian cells and its possible clinical use. The present review on this very important compound, although not very comprehensive, deals with the important characteristics; such as the action of DNA and cells, and its chromosome breaking effects. The manner in which the minute detail of the action of BLM on cells has helped to implement in vivo chemotherapeutic regimes, is also discussed.

Animals↗
PubMed1977

Carcinogenic and possible mutagenic effects of stilboestrol in offspring exposed in utero.

The relevant literature has been reviewed and it appears that there is no doubt that in utero exposure to stilboestrol is related to the eventual development of vaginal adenocarcinoma in young females. Although cancer of other types are also prevalent, the incidence is not great and may be related to other types of drugs taken during pregnancy. The review attempts to correlate the genetic effects with the abnormal development, but on account of the scarcity of data such correlation is not possible. Further work on the genetic effects and the development of the lower genital tract in the female needs to be carried out.

Abnormalities, Drug-Induced↗
PubMed1970

Temporal summation and refractoriness in hypothalamic reward neurons as measured by self-stimulation behavior.

A neurophysiological technique of double-pulse stimulation has been applied to freely moving rats with chronic indwelling electrodes in the hypothalamic reward area. Self-stimulation thresholds, measured as a function of the interpulse interval, generated curves with time constants characteristic of refractory periods and temporal synaptic summation. The results indicate a way of studying central neuronal processes for which the overt behavior of the animal is the dependent variable.

Animals↗