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Biomedical subjects

N S Mann

Publications and source records attributed to N S Mann.

At least 37 records · Page 2Linked to original sources

Sclerosing cholangitis and oxalate urolithiasis in ulcerative colitis.

We report a 56-year-old man with sclerosing cholangitis and oxalate urolithiasis. These complications occurred five years after proctocolectomy and ileostomy were performed for ulcerative colitis. Two years before, at the time of proctocolectomy, there was no clinical or biochemical evidence of liver abnormality. The occurrence and progression of sclerosing cholangitis five years after proctocolectomy is unusual. Also unusual is the occurrence of oxalate urolithiasis; more common in ulcerative colitis, especially after ileostomy, are uric acid stones.

Calcium Oxalate↗

Nasoenteral feeding tube insertion via fiberoptic endoscope for enteral hyperalimentation.

Total parenteral nutrition can maintain good nutritional status in selected patients. However, it can be accompanied by serious complications. It is generally agreed that enteral alimentation is more economical and safer. Gut should be used for nutritional replenishment whenever feasible. However, large-bore nasogastric feeding tubes can cause problems. Even fine-bore nasogastric tubes can cause aspiration pneumonia in obtunded and debilitated patients. In some patients it is clearly desirable to have the tip of the feeding tube in the distal duodenum or proximal jejunum. Previously described methods for placement of nasoenteral tubes may be unsatisfactory. We describe a safe, simple, and reliable method for endoscopic insertion of fine-bore nasoenteral feeding tube. We have used this method on 15 patients without complication.

Aged↗

Upper esophageal dysphagia due to marked cervical lordosis.

A 62-year-old patient had upper esophageal dysphagia secondary to curvature and marked lordosis of the cervical spine. Hypertrophic spurring and cervical osteophytes are known to cause difficulty in swallowing solids, but cervical lordosis is an unusual cause of upper esophageal dysphagia.

Cervical Vertebrae↗

Experimental colitis studied by colonoscopy in the rat: effect of indomethacin.

Diffuse colitis was produced in rats by the intracolonic administration of 10% acetic acid. The course and evolution of this chemical colitis was followed by performing serial fiberoptic colonoscopy and biopsy. The effect of intrarectal indomethacin on the prostaglandin E content of the colonic mucosa and on the severity of colitis as judged by endoscopic and histologic criteria was evaluated. Intrarectal administration of indomethacin was associated with decreased severity of inflammation and decreased prostaglandin E2 content of the colonic mucosa. This model may be useful in evaluating other potential therapeutic agents.

Acetates↗