Biomedical subjects

N S Kartavova

Publications and source records attributed to N S Kartavova.

10 recordsLinked to original sources

PubMed1989

[Anti-carcinogenic and anti-blastic effect of vitamin A in various modes of its administration to random-bred rats during carcinogenesis of the mammary gland, induced by 7,12-dimethylbenz(a)anthracene].

The dependence of the anticarcinogenic and antiblastic effect of retinoid on the regime of its inoculation and on the process stage has been established using the 7,12 dimethylbenz(a)anthracene-induced mammary carcinogenesis of rats. The prophylactic administration of retinoid alone and its therapeutic inoculation against a background of hormonal correction resulted in the most expressed effect that was estimated by the elongation of the latent period, incidence and growth rate of tumours, lifespan of treated animals as well as by the distribution of malignant and benign tumours.

9,10-Dimethyl-1,2-benzanthracene↗

PubMed1986

[Estradiol and progesterone receptors in DMBA-induced mammary neoplasms in rats under cyclic hormonal exposures].

Hormones in physiological doses and under cyclic regime were injected to rats with DMBA-induced mammary tumours. It is demonstrated that 17-alpha-hydroxyprogesterone capronate (HPC) alone administered once every 6 days reduces estradiol receptor (ER) and progesterone receptor (PR) levels and the frequency of R+ tumours. Under the influence of a successive use of HPC and testosterone (TS) the level of PR and the frequency of PR+ tumours were reduced. A high level of ER and PR and a high frequency of R+ tumours were observed after a successive administration of insulin, prednisolone, HPC and TS. All the variants of hormonal influences resulted in an increased life duration of animals, a reduced growth rate, and an increased degree of mammary tumour differentiation.

17-alpha-Hydroxyprogesterone↗

PubMed1986

[Effect of vitamin A and hormones on the hormonal sensitivity of DMBA-induced mammary tumors in rats].

The treatment of rats with DMBA-induced mammary tumours with vitamin A and hormones in the cyclic regime increases the lifetime of animals, decreases both the tumour growth rate and increases the degree of their differentiation. The treatment with vitamin A alone and in combination with hormones lowers the level of estradiol and progesterone receptors in the rat mammary tumours. The high frequency of receptor-positive tumours and high level of estradiol and progesterone receptors in them were observed under the influence of hormones alone in the cyclic regime.

17 alpha-Hydroxyprogesterone Caproate↗

PubMed1980

[Steroid balance in breast cancers of varying histological structure].

Patients with breast cancer in stage I--II of various histological structure showed varied hormonal disturbances. In adenocarcinoma a high level of classic estrogens or total phenolsteroids was noted. In low differentiated cancers (solid, scirrhus) the values of estrogens excretion were considerably lower, but, if correlated with other hormones (androsterone), a relative hyperestrogenization is observed. Scirrhous cancers are characterized by the increased 17-ketogenic steroids excretion. The character of hormonal disturbances concomitant with the predominant development of certain breast tumor structures (adenocarcinoma, solid cancer, scirrhus) is identical for the patients being in their reproductive and menopausal period.

17-Ketosteroids↗

PubMed1978

[Steroid balance in patients with breast hyperplasia].

A correlation was found between the character of hormonal disorders and the morphological organization of dyshormonal hyperplasias of the mammary gland. Patients with fibroadenoma and fibrous-cystic mastopathy are characterized by a high diurnal urine content of glucocorticoids and low estrogens level, especially estradiol. Patients with cystic fibroadenomatosis of the mammary gland show the high level of the excretion of classical and total phenolsteroids and low androsterone level.

Adenofibroma↗

PubMed1977