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Biomedical subjects

N S Garin

Publications and source records attributed to N S Garin.

At least 19 recordsLinked to original sources
PubMed1976

[Production and study of anthrax antigen. I. Nutrient medium for production of native anthrax protective antigen].

The authors present the results of studies concerning the choice of nutrient bases and elaboration of a medium for obtaining anthrax protective antigen providing an active preparation. Filtrates of crude cultures obtained on the nutrient medium prepared of 3% hydrochloric hydrolyzate of fish flour, corn extract, glucose, sodium bicarbonate and mineral salts proved to be the most active. Tests for determination of usefulness of the culture fluids with the maximum content in them of the protective antigen are recommended.

Anthrax↗
PubMed1976

[Preparation and study of the anthrax protective antigen. II. Development of test preparations for the assessment of the quality of anthrax chemical vaccines and of the antigens obtained at various stages of its preparation].

A homogeneous anthrax protective antigen (from the ST-I strain) characterized by a high immunogenicity and stability was obtained. Hyperimmune, monospecific to this preparation antiserum was prepared. It is suggested that these preparations can be used for the assessment of the quality of the anthrax chemical vaccine and of the antigens obtained at various stages of its preparation.

Animals↗
PubMed1975

[Preparation and comparative evaluation of experimental anthrax diagnostic sera in experiments on animals].

The authors present the results of studies on obtaining and comparative assessment of experimental anthrax diagnostic sera in experiments on various animals. Donkeys, sheep, horses, rabbits and monkeys (Papio hamadryas) were immunized with the STI-I vaccine by a single scheme. The activity of the obtained sera was tested in the diffuse precipitation reaction by the amount of the detected antibodies and the titre. The most active sera were obtained from donkeys and sheep: their titre was 5.5 and 4 times greater and amount of the detected antibodies 2.6--2 times greater than in the sera of horses used up to the present time as producers of diagnostic anthrax preparations. The least active sera were obtained from monkeys.

Animals↗