Biomedical subjects

N S Campbell

Publications and source records attributed to N S Campbell.

3 recordsLinked to original sources

PubMed2000

Duplex Doppler ultrasonography of lower limb veins: detection of cardiac abnormalities.

AIM: We describe the detection of right sided cardiac abnormalities by Doppler ultrasonography of the lower limb veins. We also attempt to quantify the degree of tricuspid regurgitation (TR) by analysis of the femoral vein Doppler waveform (DW). MATERIALS AND METHODS: The DWs of the lower limb veins were examined in 276 patients over a 17-month period. The detection of abnormal pulsatile DW was compared with echocardiography on these patients. The reports of chest radiographs (CXR) obtained on 104 of the 276 patients were reviewed. RESULTS: Abnormal cardiac pulsatility of the DW was detected in nine patients (3.3%), with abnormally high retrograde velocity peak (RVP) recordings. These abnormal RVPs are compared to RVPs in a normal control group. The RVPs in the abnormal group revealed a statistically significant (Pearson's r = 0.9113) correlation with the degree of TR observed on echocardiography. All nine patients (100%) demonstrated cardiac enlargement on CXR compared to 16 of the 95 (16.8%) with a normal DW and available report of recently performed CXR. CONCLUSION: Doppler ultrasonography of lower limb veins is a frequently performed examination in most Radiology departments. We describe a simple, effective and reproducible ultrasound technique enabling detection of an underlying cardiac abnormality that may provide an estimation of the degree of TR. These important signs should alert the examining radiologist to the presence of an underlying cardiac dysfunction that may require further appropriate cardiac evaluation.McClure, M. J. (2000). Clinical Radiology 55, 533-536.

Adult↗

PubMed2000

Clinical and hemodynamic performance of the Toronto SPV bioprosthesis.

BACKGROUND AND AIM OF THE STUDY: By providing a superior hemodynamic profile, the stentless valve design allows ventricular remodeling and may improve patient survival after aortic valve replacement (AVR). Compared with stent-mounted prostheses, implantation is more complex and requires a longer ischemic time; this may adversely affect surgical risk, especially if patients are elderly or require a concomitant procedure. The mid-term clinical and hemodynamic performance of the Toronto SPV bioprosthesis in a predominantly elderly patient group was analyzed. METHODS: A total of 123 patients (median age 72 years) underwent AVR with the Toronto SPV. Concomitant procedures (mainly coronary artery bypass grafting, CABG), were performed in 60 patients (49%). Clinical details were recorded, with 100% follow up (total 317 patient-years). Hemodynamic evaluation, by serial echocardiography, was performed at four and 18 months after implantation. RESULTS: The early mortality rate was low (0.8%). Mean (+/- SD) actuarial survival at 53 months was 78 +/- 5.9%, with most patients (91%) in NYHA classes I and II. Freedom from valve-related complications were: endocarditis 93.8 +/- 2.3%, thromboembolism 90.3 +/- 3.7% and bleeding 95.8 +/- 1.8%; there were no structural failures. The valve hemodynamic profile was excellent for all sizes: peak gradient 8.8 +/- 4.3 mmHg, effective orifice area 1.9 +/- 0.54 cm2 with significant improvement in left ventricular fractional shortening. CONCLUSION: In this patient population the Toronto SPV was a suitable choice. Advanced age, a requirement for concomitant procedures and increased ischemic times did not adversely affect surgical risk. AVR with the Toronto SPV provided an excellent hemodynamic profile, and improved both left ventricular function and NYHA functional class.

Adult↗

PubMed1970

The Indiana Biomedical Information Program.

In 1966, the Indiana University School of Medicine Library became part of a statewide teletype network. Biomedical personnel throughout Indiana may use the resources of the Library by requesting either specific books and articles or bibliographic searches through local public libraries which relay the requests to the School of Medicine Library. All transactions except reference questions receive twenty-four-hour service. The popularity of such a facility is indicated by the fact that 472 identified borrowers used it during the twenty-five months between its inception and December 31, 1968. Over half of the borrowers have used it repeatedly, and as many as 358 transactions have occurred in a single month. The largest group of borrowers consists of practicing physicians. It is felt that the enthusiastic response to the service justifies its continuation and expansion.

Indiana↗