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Biomedical subjects

N Rushton

Publications and source records attributed to N Rushton.

85 records · Page 5Linked to original sources
PubMed1989

Total hip replacement in the renal transplant recipient.

Osteonecrosis of the femoral head is a severely disabling complication of steroid immunosuppression in renal transplant patients. We report 31 total hip arthroplasties in 21 renal transplant recipients with an average follow-up of six years. There were no problems with wound healing or infection despite full immunosuppression. Four hips developed symptomatic loosening but the other results were excellent, comparing well with other methods of treatment for osteonecrosis. Ten patients died during the follow-up period. Total hip replacement is a safe and effective treatment for transplant recipients and, in view of their limited life expectancy, should be considered at an early stage in their treatment.

Aged↗
PubMed1989

The influence of the surface energy and roughness of implants on bone resorption.

We investigated the possibility that the macrophages which are seen around implants may stimulate bone resorption and cause loosening. We found that macrophages release mediators that stimulate bone resorption, and that the amount of resorption increased by between 2.5 and 10 times when the macrophages adhered to a foreign surface. This bone resorption depended on the surface energy and roughness of the foreign surface, varying with these physical properties rather than with the chemical nature of the material. It is concluded that loosening of orthopaedic implants is likely to be influenced by the surface energy and roughness of the implant.

Animals↗
PubMed1989

The effect of starch glove powder on joint and other tissues.

The purpose of this research was to establish the possible role of starch glove powder in complications following orthopaedic surgery using in vivo and in vitro techniques. Exposure of primary mouse peritoneal macrophages to starch glove powder caused 10% release of prostaglandin E2 (0.1 mg/ml, 16 h) but no increased release of lactate dehydrogenase, demonstrating that cell integrity had not been compromised. Long-term tissue reaction to starch glove powder was investigated in vivo by injection into mouse knee joints. Over a period of 52 weeks no inflammatory response was elicited, no starch was observed in the regional lymph nodes and none was found in joints after the 8th week. Starch glove powder appeared to be innocuous in the joint and although prostaglandin E2 release was stimulated in vitro, this had no apparent effect on joints in vivo.

Animals↗
PubMed1987

Three years after Colles' fracture. A prospective review.

A prospective study was made over a three-year period of 900 consecutive unilateral Colles' fractures. The radiographic features at the time of fracture, after reduction and one week later were measured and correlated with grip strength and range of movement at three years. The most significant radiographic feature to influence the outcome was the presence of shortening of the radius one week after reduction of the fracture. Persistent dorsal tilt, radiocarpal joint involvement and ulnar styloid fracture were each associated with reduced range of movement, but had no effect on grip strength. Extension of the fracture into the distal radio-ulnar joint was associated with reduced grip strength but had no effect on range of movement. Radial tilt of the radial fragment did not correlate with any aspect of the result after three years.

Aged↗
PubMed1984

The intra-articular response to particulate carbon fibre reinforced high density polyethylene and its constituents: an experimental study in mice.

Carbon fibre reinforced high density polyethylene (CFRHDP) Meuller acetabular cups are available for total hip replacement. Despite the improved mechanical properties of CFRHDP over high density polyethylene (HDP) the wear characteristics of CFRHDP are a contentious issue. The biocompatibility of CFRHDP wear debris was investigated by intra-articular injection into mice and compared with that induced by HDP and carbon fibres. The response to CFRHDP was identical to that seen with HDP: the carbon fibre component did not appear to modify the response. From the biological point of view, therefore, the wear properties of CFRHDP must be better than those of HDP to offer a significant advantage.

Animals↗
PubMed1983

The clinical, arthroscopic and histological findings after replacement of the anterior cruciate ligament with carbon-fibre.

Thirty-nine patients underwent reconstruction of the anterior cruciate ligament with carbon-fibre and a MacIntosh repair; all had a negative pivot shift test after operation. Some patients had persistent pain, mild effusion and synovial thickening; in 10 of these patients the symptoms warranted arthroscopic examination and biopsy at a mean of 16.9 months after the repair. Arthroscopy revealed that the carbon-fibre had not induced the formation of a "new ligament" and that the repair was merely covered by a thin, fibrous sheath. Histological investigations confirmed this finding, with only a suggestion of a fibroblastic response to carbon-fibre found in two patients. Particles of carbon-fibre were found scattered through the knees. Synovitis and breakdown of the skin over subcutaneous carbon-fibre complicated treatment. Failure of the carbon-fibre to bond to bone was detected radiographically.

Adolescent↗
PubMed1982

Revision hip arthroplasty. A retrospective survey.

A survey of revision hip arthroplasties was performed, using a retrospective review of the patients' case notes and radiographs, and an assessment of the patients, at least 1 year after the revision. The patients were divided into three categories: a) First revision hip arthroplasty (41 patients); b) Second revision hip arthroplasty (8 patients); c) Revision of femoral hemi-arthroplasty (14 patients). The reasons for revision, the type of revision and the final outcome have been identified in each group. This is the first study which allows direct comparison of the final outcome, as assessed by accurate objective criteria, between patients having revision hip arthroplasty for different reasons. Radiographs of the hip arthroplasty after the original operation and after revision have been analysed. The final outcome of first revision hip arthroplasty and revision of hemi-arthroplasty to total hip replacement was generally good. The outcome of second revision hip arthroplasty was generally poor.

Adult↗
PubMed1980

Technetium 99m methylene diphosphonate scanning in Thompson hemiarthroplasties.

Fourteen patients who had had Thompson hemiarthroplasties at least ten months previously were scanned using 555 MBq (15mCi) 99Tcm methylene diphosphonate. No hips were infected, the control group of eight firmly fixed prostheses showed a weak diffuse uptake pattern whilst five of six patients with loose prostheses showed a characteristic focal distribution of increased uptake.

Aged↗
PubMedDate not supplied

Neoplastic transformation of cells by soluble but not particulate forms of metals used in orthopaedic implants.

Recent developments in cell culture techniques have made it possible to study the cellular mechanisms involved in carcinogenesis and to apply these methods as screening tools in vitro. This study investigated and compared the ability of the metals most commonly used in orthopedic implants to induce toxicity and neoplastic transformation in the C3H10T1/2 mouse fibroblast cell line. Eight metals (cobalt, chromium, nickel, iron, molybdenum, aluminium, vanadium and titanium) and their alloys (stainless steel, cobalt-chrome alloy and titanium alloy) were tested, both as soluble salts and as solid particles. There were marked differences between the various metals in terms of both toxicity and transforming ability. Significant increases in the incidence of cell transformation were seen with soluble forms of cobalt, chromium, nickel and molybdenum but not with iron, aluminium, vanadium or titanium. For most of the metals. transforming ability was directly related to toxicity, although this correlation did not hold for either molybdenum or vanadium. The physical form of the metal was critically important in determining its effects, and transformation occurred only with soluble metal salts.

Alloys↗
PubMedDate not supplied

The surgical anatomy of the stifle joint in sheep.

OBJECTIVE: To provide a detailed description of the surgical anatomy of the stifle joint in sheep. STUDY DESIGN: The results from analysis of cadaveric dissections (14 stifle joints) and stifle radiographs (8 sets of mediolateral and craniocaudal radiographs) are presented. ANIMALS: Skeletally mature ewes of mixed breeds. CONCLUSIONS: Although the anatomy of the ovine stifle joint is similar to that of the human knee joint, a number of unique features were identified. These included the presence of the tendon of the m. extensor digitorum longus on the craniolateral aspect of the stifle joint, the absence of a cranial meniscofemoral ligament (ligament of Humphrey) in the caudal joint space, and attachment of the patellar tendon to the cranial pole of the patella (rather than to the distal pole, as in humans). The implications of these differences are discussed with reference to the suitability of the ovine stifle as a surgical model for the human knee joint.

Animals↗