Biomedical subjects
N Roberts
Publications and source records attributed to N Roberts.
The relationship arrhythmias and conduction disturbances to other manifestations of cardiopulmonary disease in progressive systemic sclerosis (PSS).
Disorders of rhythm and conduction are characteristic of the cardiac involvement in progressive systemic sclerosis (PSS), but their over-all frequency in PSS is not well established. Therefore, 46 ambulatory patients with PSS underwent several tests of cardiopulmonary function, including a 24-hour continuous electrocardiogram (Holter monitor). Conduction disturbances (sinus node dysfunction, first-degree heart block, pre-excitation), supraventricular arrhythmias (supraventricular tachycardia, atrial fibrillation, premature contractions of atrial or junctional origin) and ventricular arrhythmias (ventricular tachycardia, multifocal premature contractions) were observed on Holter monitoring in 26 subjects. Although these arrhythmias and conduction disorders were predictably observed in patients who complained of palpitations or syncope, or who had an electrocardiogram which showed first-degree heart block, ventricular bigeminy, left anterior superior hemiblock, prolonged p wave, right or left axis deviation, right or left ventricular hypertrophy, pathologic Q waves or low voltage, they were often found in patients who lacked other clinical evidences of heart disease. Arrhythmias and conduction disturbances were not significantly more frequent among patients with cardiomegaly or interstitial change on chest roentgenogram nor were they related to the presence or severity of abnormal lung function. This study suggests that Holter monitoring may be a valuable adjunct in evaluating heart disease in PSS.
Occurrence of Vibrio cholerae serotype O1 in Maryland and Louisiana estuaries.
Vibrio cholerae serotype O1 has been isolated from Chesapeake Bay in Maryland and estuaries and sewers in Louisiana. The occurrence of V. cholerae O1 in the aquatic environment in the absence of human disease suggests that this organism survives and multiples in the natural environment.
The effect of ranitidine and cimetidine on pentagastrin and insulin stimulated gastric secretion.
Explore the source record for details and available documents.
Prenatal care in the prevention of infection.
Explore the source record for details and available documents.
Presence of serotonin in the palate just prior to shelf elevation.
Since serotonin and its antagonists affect shelf rotation in mouse embryo culture, experiments were carried out to determine whether a serotonergic system is present in the palate. Employing [3H]5-HT, day-14.5 embryos incorporated the monoamine into palates. Active uptake of [3H]5-HT was shown since excised palates incorporated 9-fold more radioactivity at 37 degrees C than at 4 degrees C. Synthesis of palatal serotonin was measured. Embryos were cultured in the presence of the serotonin precursor, [3H]5-HTP, and radioactive 5-HT was monitored in the palate by thin-layer chromatography. Furthermore, excised palates were incubated with [3H]5-HTP and radioactive 5-HT was measured. Incorporation was linear for about 6 h. In addition, another radioactive compound was detected which had the same Rf as the methylated derivative, 5-methoxytryptamine. Synthesis of this compound was appreciable, about 30% of that of serotonin. Levels of serotonin in the palate were measured by high pressure liquid chromatography. Palates at day 14.5 of gestation contained 0.40 ng serotonin/mg protein, which was greater than that of tongue (0.33), body (0.14) but less than that of brain (3.09). Serotonin in palate and other embryonic tissues increased with time of development. Dopamine levels in the palate and other tissues were also determined. The distribution of serotonin in the palate was analyzed by culturing day-14.5 embryos in the presence of [3H]5-HTP, and after aldehyde fixation, paraffin embedment and sectioning, autoradiography was performed. Grains were observed throughout the palate in cells of regions 2 and 3, internal mesenchyme, tooth germ, and epithelium. Surprisingly, the pterygopalatine nerve, maxillary nerve and pterygopalatine ganglion contained an appreciable concentration of grains. Thus, the presence of serotonin in the palate is consistent with the neurotransmitter playing a role in shelf elevation.
Congenital heart disease in Florida. A predictive study.
Explore the source record for details and available documents.
A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma?
Six long term survivors of bone marrow transplants developed a syndrome similar to progressive systemic sclerosis (PSS). Cutaneous involvement (6/6), pulmonary disease (6/6), musculoskeletal involvement (4/6), keratoconjunctivitis/positive Schirmer's test (4/6), Raynaud's phenomenon (2/6), and renal and cardiac disease (1/6) were similar to findings in PSS patients. T and B lymphocyte counts and functions were also similar. This PSS-like syndrome, including visceral involvement, after bone marrow transplantation lends support to an immunologic hypothesis of the pathogenesis of progressive systemic sclerosis.
A predictive study of congenital heart disease and need for care.
For long-term planning in the delivery of health care, prevalence data are essential for budget estimates in terms both of distribution and training of manpower and fiscal responsibility. From incidence figures, from the knowledge of the natural history of congenital heart disease and from predicted population estimates it is possible to construct a model that reflects the prevalence of congenital heart disease. This has been done for the state of California; the methods used and the data gathered should prove useful nationally. It is estimated that there were in 1975 in California 17,531 children under 21 years of age with congenital heart disease; 24 percent of these had ventricular septal defects and 23 percent had pulmonary stenosis, 11 percent had atrial septal defects and 9 percent had aortic stenosis; the other forms of congenital heart disease constituted the remaining 33 percent. Based on these estimates it is then possible to plan the medical resources necessary for optimal care.
Postoperative trifascicular block complicating tetralogy of fallot repair.
Transient and residual conduction defects, including early and late complete heart block, are not uncommon in children following the intracardiac repair of tetralogy of Fallot. The case of a young girl is described, in whom early, transient complete heart block was found to be due to trifascicular damage. Through serial electrophysiological studies, gradual improvement in the conducting system was documented, although residual trifascicular damage remained. It is believed that all children with evidence of residual trifascicular damage are subject to possibly fatal bradyarrhythmias due to late postoperative complete heart block.
Mothers' speech to children of four different ages.
This study reports analyses, in terms of five different measures, of the speech on two standard tasks of 32 middle-class mothers to their children aged 1 1/2, 2 1/2, 4, and 6 years. Sex and birth order of child were not found to be related to mothers' speech. On four of the measures, both task and age of child had strongly significant effects. In general, with increasing age of child, mothers spoke more, in longer and grammatically more complex utterances, with greater diversity of vocabulary. The differences in speech addressed to 1 1/2-year-olds and that addressed to 2 1/2-year-olds were particularly marked.
Denervation in the primary olfactory pathway of mice: biochemical and morphological effects.
Explore the source record for details and available documents.
Prediction of left ventricular pressure from the vectorcardiogram in transposition of the great arteries.
Explore the source record for details and available documents.
Supravalvular pulmonary stenosis.
Explore the source record for details and available documents.
His bundle electrogram in children. Statistical correlation of the atrioventricular conduction times in children with their age and heart rate.
Explore the source record for details and available documents.
Mimics of bacterial endocarditis.
Explore the source record for details and available documents.
Sir Walter Mercer.
Explore the source record for details and available documents.
The heights and weights of Indian and Eskimo school children on James Bay and Hudson Bay.
Explore the source record for details and available documents.