Search PubMed⌕ Search

Biomedical subjects

N Rao

Publications and source records attributed to N Rao.

At least 109 records · Page 6Linked to original sources

Autopsy findings in the eyes of fourteen fatally abused children.

The eyes of fourteen fatally abused children and sixteen control cases were examined histopathologically. Ten of the abused children showed intraocular change. The most common ocular changes were subdural hemorrhage of the optic nerve and retinal hemorrhage which involved all the layers of the retina, but most commonly the nerve fiber layer, ganglion cell layer and inner nuclear layer. The presence of blood cavities within the retina partially supported the hypothesis of traumatic retinoschisis. The control cases of non-abused children rarely showed intraocular hemorrhage.

Child Abuse↗

Cost-effective eradication of an outbreak of methicillin-resistant Staphylococcus aureus in a community teaching hospital.

During an eight-month period, 25 hospitalized patients became infected or colonized with methicillin-resistant Staphylococcus aureus (MRSA) in a 464-bed acute care, medical-surgical teaching hospital. There were only five cases during the eight months prior to the outbreak period (P less than 0.0001). Initial measures, including category-specific isolation and education, did not limit the spread of the outbreak of a strain of MRSA. This prompted institution of additional measures including (1) strict isolation of all infected and colonized cases; (2) prospective microbiological surveillance to detect additional cases; (3) multiple site cultures of identified cases to determine the extent of colonization; (4) employee and environment surveillance; (5) antibiotic decolonization of patients and employees; and (6) educational efforts. The highest number of personnel carriers were noted in one of the critical care units where most of the cases occurred. The decolonization protocol was 100% effective for personnel carriers. The incidence of nosocomial cases of MRSA fell to zero in the five months following the implementation of the strategy. The cost of the entire eradication process was approximately half that of treating a single MRSA bacteremia.

Cost-Benefit Analysis↗

The art of medicine: subjective measures as predictors of outcome in stroke and traumatic brain injury.

This study was designed to explore new ways of predicting the functional outcomes of stroke and brain injury patients. Upon admission and initial assessment of functional performance, we used an on-line computer program to indicate the most important and subjective judgment items to set rehabilitation goals for patients. The functional performance and discharge outcomes of patients from an inpatient program were measured by using five nonmedical functional items from the patient evaluation conference system (PECS). For stroke patients we most frequently selected motor loss, perceptual/cognitive deficit, spasticity, sensory deficit (PECS medical items), and comprehension (subjective cue). For traumatic brain injury patients, however, we selected motor loss, perceptual/cognitive deficit, spasticity (PECS medical items), communication, and comprehension (subjective cues). Data were statistically analyzed using the Fisher Exact Test. Of the medical function items, a level of independence in the sensory deficit function in stroke patients at admission was associated with a patient achieving independence in ambulation at discharge. Demonstrating a moderate or maximum level of attention, concentration, and realism was positively related to a patient achieving a level of independence in ambulation at discharge. Independence in the function items of behavior and interaction was associated with moderate or maximum levels of comprehension at admission. In traumatic brain injury patients, none of the subjective cues were associated with achieving independence at discharge in any of the functional levels. This paper demonstrates the value of developing a way to assess subjective measures that are based on their ability to predict outcomes. Using such a method, new predictive measures can be developed.

Adolescent↗

Mycobacterium chelonei keratitis after radial keratotomy.

Two patients who had undergone radial keratotomy developed delayed postoperative infectious keratitis. Both patients had surgery at the same outpatient facility, and their procedures had been performed by the same surgeon. The corneal lesions appeared similar in both cases, consisting of white irregular infiltrates with radiating projections and fluffy, indistinct margins. Although they were found at all levels, the lesions were most concentrated in the mid-to-deep stroma and were associated with overlying epithelial defects. In both cases, Mycobacterium chelonei was isolated from corneal biopsy specimens. Both patients were treated with topical fortified amikacin; in one there was complete resolution of the corneal infiltrates with medical therapy alone. Although the other patient's lesions initially appeared to resolve with medical therapy, she eventually required corneal transplantation because of recurrence of the infiltrates. Histopathologically, the infiltrates consisted of myriads of acid-fast bacteria with rare inflammatory cell infiltrations.

Adult↗

Rehabilitation team and family assessment of the initial home pass.

Brain-injured individuals may have neurologic damage resulting in physical, cognitive and personality sequelae. Rehabilitation promotes recovery for these patients by restoring cognitive and social functions and focusing attention on medical-physical and cognitive-social intervention. A major component in rehabilitation is to teach family members to understand the process of recovery and their role in teaching and reinforcing desired behaviors at home. To investigate the utility of the family's role, we studied the effects of allowing patients to return to the home/family environment for short stays (therapeutic pass). By comparing functional ratings obtained from family and rehabilitation team members, we found families rated brain-injured patients higher in medical-physical areas and more equally in cognitive-social areas. Although we do not control for the family's frame of reference regarding the patient's premorbid status, we conclude that impaired cognitive functioning has a profound impact on family members who, like the patient, must make adjustments because of the disability. We recommend therapeutic passes as a meaningful tool in the process of educating families about the disability, its scope and impact, as well as its accompanying effects on cognitive and social functioning.

Brain Injuries↗

Mucoepidermoid carcinoma of the lacrimal gland. Case report and review of the literature.

A 12-year-old girl was diagnosed as having mucoepidermoid carcinoma of the lacrimal gland. To our knowledge, only 14 cases of mucoepidermoid carcinoma of the lacrimal gland have been reported in the literature; this is the first case occurring in a child. Clinically, this tumor presented as a painless proptosis with inferonasal displacement of the globe. Histologically, it showed infiltrating lobules of neoplastic cells consisting of epidermoid cells admixed with mucin-containing cells and a mild lymphocytic infiltration in the stroma. The mucous cells stained positively with periodic acid-Schiff, Alcian blue, and mucicarmine dyes, but resisted digestion with hyaluronidase. This case illustrates that one should not exclude any diagnostic possibility just because the patient does not seem to belong to the appropriate age group.

Carcinoma↗

Agitation in closed head injury: haloperidol effects on rehabilitation outcome.

The role of agitation as a prognostic indicator of outcome in 26 patients with severe traumatic closed head injury was studied to explore haloperidol effects on the outcome of rehabilitation treatment. The incidence and degree of agitation and post-traumatic amnesia (PTA) in brain-injured patients undergoing comprehensive inpatient rehabilitation were also studied. Variables measured included length of coma, PTA, rehabilitation admission and discharge functional status, and CT scan results. Of the 26 patients, 25 were agitated after emerging from coma and 11 required intervention with haloperidol. Treated and nontreated patients were compared statistically. No differences were found between groups as to demographics, length of coma, and most importantly, in success of rehabilitation outcome. The duration of PTA was significantly longer in the treated group.

Amnesia↗

18F positron emission computed tomography in closed head injury.

Locus and extent of cerebral dysfunction in five closed head injured patients as inferred from positron emission tomography (PET) and computed tomography (CT) scan studies were compared with locus and extent inferences made in the same five patients using three additional independent sources of data. These data included: (1) clinical neurologic examination findings, (2) an extensive battery of neuropsychologic tests (including WAIS, Wechsler Memory, Halstead Reitan procedures), and (3) a comprehensive speech and language assessment battery (including the Boston Diagnostic Aphasia Examination (BDAE) and the Token Test). Neurologic, psychologic, and speech examinations were conducted within one week of the PET and CT studies. Three patients were studied at three months, one patient at six months, and one patient at two years after head injury. Follow-up CT scans were done 14 months later on four of five patients. This study supported the following major conclusions: the PET findings closely correspond with the site and extent of cerebral dysfunction inferences derived from the neurologic and behaviorial examinations but the CT findings did not; the follow-up CT scans, however, showed structural abnormalities (ie, encephalomalacia and atrophy) that were consistent with the PET, neurologic examination, and behavioral assessment findings; the study strongly supports the validity and predictive utility of neurobehavioral data which are directly pertinent to rehabilitation planning/programming in patients with closed head injury.

Brain↗

Computerized tomography head scans as predictors of rehabilitation outcome.

This study explored the relationship between rehabilitation functional outcome, demographic characteristics, and predicted goal achievement for 30 patients with closed head injury according to characteristics of their computerized tomography (CT) head scans performed within 10 days of injury. Goals and outcome were measured according to levels of independent/dependent function at discharge from an interdisciplinary inpatient rehabilitation program by means of the Patient Evaluation Conference System (PECS). Patients were classified into the three following major subgroups according to CT findings: (1) normal; (2) 1 hemisphere lesion; and (3) bilateral lesion. Marked differences in patient outcome and in the team's ability to accurately predict outcome were found to match the subgroups so classified. The need to incorporate CT scan data into early team planning and goal setting is stressed.

Adult↗

Cytochrome c oxidase is preferentially synthesized in the rough endoplasmic reticulum--mitochondrion complex in rat liver.

The specific activity and content of cytochrome oxidase in the rough endoplasmic reticulum--mitochondrion complex are higher than in the mitochondrial fraction. Radiolabelling studies with the use of hepatocytes and isolated microsomal and rough endoplasmic reticulum--mitochondrion fractions, followed by immunoprecipitation with anti-(cytochrome oxidase) antibody, reveal that the nuclear-coded cytoplasmic subunits of cytochrome oxidase are preferentially synthesized in the latter fraction. The results have a bearing on the mechanism of transport of these subunits into mitochondria.

Animals↗

Crystal structure of galactan-binding mouse immunoglobulin J539 Fab at 4.5-A resolution.

An electron-density map of the mouse galactan-binding immunoglobulin J539 (IgA2,kappa) Fab has been calculated to a resolution of 4.5 A by the method of heavy atom isomorphous replacement with four derivatives. The map has been interpreted with the aid of a computer program which systematically searched for the best fit between the electron-density map and the known coordinates of individual immunoglobulin domains. The quaternary structure of J539 Fab at this resolution appears similar to that of another mouse immunoglobulin, IgA2,kappa Fab, McPC603. The model coordinates for J539 Fab should allow us to proceed directly to a high-resolution structure determination without further heavy atom isomorphous replacement.

Animals↗