Diencephalic sites responsive to prostaglandin E2 facilitation of sexual receptivity in estrogen-primed ovariectomized rats.
Crystalline prostaglandin E2 (PGE2) induced high levels of sexual receptivity when stereotaxically implanted into the antirior-bala hypothalamic and preoptic regions of estrogen-primed, ovariectomized rats. Anterior- as well as medial basal hypothalamic implants of PGE2 induced a significant elevation of rectal body temperature, but had no effect on open-field activity scores. The possibility that PGE2 exerts its facilitatory effects upon sexual receptivity via an LHRH mechanism is discussed.
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