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Biomedical subjects

N R Galloway

Publications and source records attributed to N R Galloway.

6 recordsLinked to original sources
PubMed1979

Intraocular pressure reduction in chronic simple glaucoma by continuous infusion of dilute pilocarpine solution.

Ten hospital outpatients with bilateral chronic simple glaucoma received a single drop of 2% pilocarpine to one eye and a continuous infusion of 0.1 % pilocarpine at a flow rate of 0.01 ml/min to the other eye (both solutions were at pH 7.2). On another occasion the treatments were reversed. Measurements of intraocular pressure (IOP) and pupil diameter were made at 30 min intervals for 2 hours. The continuous infusion of dilute solution was as effective as the single drop of more concentrated solution in reducing IOP and in constricting the pupil; the drop was somewhat faster in producing its effect.

Aged↗
PubMed1976

A comparison of the pupilloconstrictor effect of pilocarpine solution administered to the conjunctival sac as a single drop or as a continuous infusion in normal subjects.

Pilocarpine was administered into the conjunctival sac of normal volunteers by single-drop administration or by continuous infusion of a solution to the inner canthus by means of a fine Silastic tube. Using pupilloconstriction as a measure of response it was shown that infusion with a 0-01 per cent solution of pilocarpine was as effective as a single drop of 0-5 per cent pilocarpine. The response to the single drop was faster at onset. It was demonstrated that at pH 7-2 pilocarpine was more effective than at acid pH. The infusion method is simple to use, comfortable for long periods, has potential for reducing the need for frequent drop administration and for reducing the total amount of drug administered, and could be used for drugs other than pilocarpine.

Administration, Topical↗
PubMed1976

Continuous infusion of the conjunctival sac with pilocarpine in normal subjects and in patients with chronic glaucoma.

(1) A drug solution can be infused into the conjunctival sac by a simple method that does not cause overflow of solution. (2) At near neutral pH, pilocarpine infused at 1 mug/min was as effective as a single dose of 125 mug as a pupilloconstrictor in normal subjects. (3) At near neutral pH, pilocarpine infused at 10 mug/min was as effective as a single dose of 1 mg as an ocular hypotensive in cases of chronic simple glaucoma. (4) The infusion system described could find application in those situations in which it is essential to maintain a known and constant concentration of drug in the conjunctival sac.

Conjunctiva↗
PubMed1976

Continuous infusion of the conjunctival sac with chloramphenicol in preoperative cataract patients.

(1) Administration of a drug solution to the conjunctival sac by means of continuous infusion through a fine-bore silicone elastomer tube has been shown to be a simple and practical method in hospital inpatients. The use of a body-borne clockwork-driven syringe ram allows the patient to be ambulant. (2) The use of continuous infusion reduces the nursing supervision required compared with repeated administration of drops. (3) Further work will be needed to established the optimum concentration of chloramphenicol needed to equal that achieved by repeated instillations. (4) The flow rate of the infusion producing no overflow, particularly in elderly patients, is likely to be less than 0-01 ml/min.

Aged↗