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Biomedical subjects

N R Farnsworth

Publications and source records attributed to N R Farnsworth.

240 records · Page 14Linked to original sources
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Potential anticancer agents IX. Isolation of a new simaroubolide, 6alpha-tigloyloxychaparrinone, from Ailanthus integrifolia ssp. calycina (Simaroubaceae).

Chaparrinone (1) and 6alpha-tigloyoxychaparrinone (2) were shown to be responsible for the antitumor and cytotoxic activities of the root bark of Ailanthus integrifolia ssp. calycina. The structure of the latter compound was established by analysis of spectral data. Compound 2 exhibited a more pronounced biological activity than chaparrinone (1) and demonstrates, for the first time, anticancer activity of a simaroubolide ester substituted at only the 6-position.

Animals↗
PubMedDate not supplied

Biological and phytochemical investigations of Dianthus barbatus cv. "China Doll" (Caryophyllaceae).

From the aerial parts of Dianthus barbatus cv. "China Doll", two saponins (barbatosides A and B) were isolated and shown to have analgesic and anti-inflammatory activities. The aglycone of each saponin was identified as quillaic acid. The glycone of barbatoside A consisted of rhamnose, arabinose, fucose, xylose, galactose, glucose and one unidentified sugar; whereas the glycone of barbatoside B contained arabinose, fucose, xylose, mannose, galactose, glucose and three unidentified sugars. Astragalin, kaempferol-3-O-beta-D-sophoroside, D-pinitol and L-leucine were also isolated.

Acetates↗
PubMedDate not supplied

Structure elucidation of norlaureline and puterine, new noraporphine alkaloids from Guatteria elata.

The structures of norlaureline (1) and puterine (4), new noraporphine alkaloids isolated from Guatteria elata (Annonaceae), were established by interpretation of the optical rotation, uv, ir, pmr, and mass spectral data of their N-acetyl derivatives. Proposed structures were confirmed by transformation of 1 and 4 to laureline (3) and pukateine methyl ether (6), respectively.

Aporphines↗
PubMedDate not supplied

Alkaloids and coumarins of Thamnosma montana.

From the turpentine broom, Thamnosma montana, four alkaloids and three coumarins were isolated and characterized. Skimmianine (5), N-methyl-acridone (4) and 5-(3'-methyl-2',3'-dihydroxybutanyl)-8-methoxypsoralen (1) were obtained previously from T. montana. Robustine (2) is reported from a Thamnosma species for the first time and acridone (6), thamnosmonin (9), and thamontanin (14) are reported from a natural source for the first time. Evidence for the structures of the new isolates is presented.

Alkaloids↗