Aqueous extracts of Pteryxia terebinthina var. terebinthina were shown to possess antiarrhythmic activity. A novel furanocoumarin, pterybinthinone, the known coumarins pteryxin and umbelliferone, and sucrose were isolated from this plant. Attempts to re-isolate a structurally undefined, defibrillatory substance by means of a published protocol were unsuccessful.

Aconitum↗

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Plant anticancer agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana.

The anticancer activity of the roots of Ervatamia heyneana (Apocynaceae) was found to be due principally to the known alkaloid, camptothecin (1). The closely related, but less active, 9-methoxycamptothecin (2) was also obtained. This is the first reported isolation of these biogenetically interesting alkaloids from the indole alkaloid rich Apocynaceae.

Antineoplastic Agents, Phytogenic↗

PubMedDate not supplied

Potential anticancer agents. XIV. Isolation of spruceanol and montanin from Cunuria spruceana (Euphorbiaceae).

Montanin (1) and spruceanol (2), two quite different diterpenes, were found to be responsible for the cytotoxic and antitumor activity of the root and root bark of Cunuria spruceana (Euphorbiaceae). The structure of spruceanol (2) was deduced from spectral interpretation and chemical correlation with 12-methoxycleistanth-8,11,13-trien-3-one (4).

Abietanes↗

PubMedDate not supplied

Constituents of Nealchornea yapurenis (Euophorbiaceae).

Extracts of Nealchornea yapurensis Huber (Euphorbiaceae) displayed cytotoxic activity; from the active fractions, five known compounds acetylaleuritolic acid, scopoletin, hexacosanoic acid, beta-sitosterol and beta-sitosterol glucoside were obtained. None of these compounds displayed cytotoxic activity.

Animals↗

PubMedDate not supplied

Potential anticancer agents. XVI. Isolation of bicyclofarnesane sesquiterpenoids from Capsicodendron dinisii.

The cytotoxic drimane derivatives cinnamodial (1), capsicodendrin (2), a partially characterized tetramer of 1, and cinnamosmolide (3) were obtained from Capsicodendron dinisii (Canellaceae). A new compound, 6 beta-acetoxyisodrimenin (4) and ugandensolide (5) and futronolide (6) were also isolated, but were not cytotoxic.

Animals↗