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Biomedical subjects

N Peparini

Publications and source records attributed to N Peparini.

27 records · Page 2Linked to original sources
PubMedDate not supplied

[Sialomucins in the follow-up of patients surgically treated for colorectal cancer: preliminary results of a prospective study].

Preliminary results of a prospective study on sialomucin content found either at resection margins of colo-rectal cancer after curative surgery or in endoscopic biopsy specimens of colonic mucosa in thirteen patients selected for the follow up are reported. Though not statistically significant because of the small number of cases enrolled, preliminary data indicate that clinical application of differential mucin staining in colo-rectal neoplasms is potentially useful to predict subgroups of patients at risk for local recurrence as well as metachronous colo-rectal cancers.

Adult↗
PubMedDate not supplied

[Lymphadenectomy and nerve sparing technique in radical surgery of rectal cancer].

The extension that should be given to lateral lymphadenectomy in the surgical treatment of extraperitoneal rectal cancer has not yet been assessed because of the difficulty of realizing randomized prospective clinical trials. The theoretical advantage of an extended lateral lymphadenectomy is represented by an accurate staging of the tumour in patients undergoing surgery for possible curative resection; even if the high percentage (20 per cent) of pelvic node metastasis was already demonstrated, the prognostic impact of lateral lymphadenectomy was not proven until now. The results of the Literature demonstrated that an advanced rectal cancer can not be treated only by conventional surgery: radical surgery (with total mesorectal excision and pelvic lymphadenectomy) or, in alternative, a combined approach-chemo-radiotherapy+surgery-should-be applied in order to improve the 5-year survival and to reduce the percentage of local recurrence. With regard to surgery the main disadvantage for an extended lateral dissection is represented by the high incidence of urinary and sexual dysfunctions. The nerve-sparing technique, when combined to pelvic lymphadenectomy, allows preservation of autonomic innervation to the pelvis. The results of our experience demonstrated that nerve-sparing technique is an effective procedure that reduces the incidence of urinary and sexual dysfunctions when accurately performed.

Adult↗
PubMedDate not supplied

[Our experience with lymphadenectomy in gastric cancer surgery].

The Authors in this work study a comparison between 27 patients who underwent total gastrectomy with "regional" lymphadenectomy for gastric cancer during the period 1986-1991 (Group A), and 27 patients who underwent total or sub-total gastrectomy associated to D2 or D3 lymphadenectomy (Group B) according to the rules of the Japanese School (localization of the neoplasia and node involvement). No statistically relevant differences were shown in the overall long term survival, although in the group B there were both an high number of patients with stage III neoplasia and more invasive carcinomas. Extended lymphadenectomies, regional and D2 or D3, gave good results as far as long term survival was concerned in early stage cancers, but the same success was not achieved in advanced cancers especially in stage III. In order to improve the survival in advanced neoplasias since one year a D4 lymphadenectomy is performed in T2 or T3 and/or N2+ cases.

Female↗