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Biomedical subjects

N Parhami

Publications and source records attributed to N Parhami.

25 records · Page 2Linked to original sources
PubMed1979

Determination of C1q in human sera.

All detectable C1q in serum is precipitated with the euglobulin fraction, and all other detectable hydroxyproline-containing protein in serum is excluded from this fraction. Since C1q contains 4.3% hydroxyproline, an estimate of its content in serum can be calculated by multiplying the hydroxyproline content of the euglobulin fraction by 23.3. The mean value of C1q in five normal male subjects determined by this method was found to be 63 microgram/ml as compared with 144 microgram/ml when determined by RID, indicating that the latter procedure seriously overestimates C1q in serum. C1q content of serum from patients with RA was found to be elevated by both procedures.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Frostbite arthritis.

We report a case of unilateral frostbite arthritis in a 58-year-old male. Clinical and radiological changes mimicked those of erosive osteoarthritis. Patients with this presentation should be carefully questioned for a history of exposure to cold, and frostbite arthritis should be considered in the differential diagnosis.

Acute Disease↗
PubMedDate not supplied

Gangrene of a foot secondary to systemic lupus erythematosus with large vessel vasculitis.

A 28-year-old man developed gangrene of a foot leading to a below-the-knee amputation. Although initially diagnosed as atherosclerotic vascular disease, clinical and laboratory findings of systemic lupus erythematosus (SLE) developed over the next 18 months. Histologic review of popliteal and femoral artery specimens showed acute and chronic changes consistent with the vasculitis of SLE. Subsequent treatment with prednisone controlled the vasculitis as well as the other clinical manifestations of SLE. The diagnosis of SLE should be considered in patients with large vessel peripheral vascular disease who lack the typical findings of the more common predisposing causes.

Adult↗
PubMedDate not supplied

The clinical significance of protein-bound hydroxyproline fractions in sera of patients with adult rheumatoid arthritis.

Clq levels in sera of adult patients with rheumatoid arthritis (RA) were found to be significantly higher than corresponding levels of normal subjects (p less than 10(-3)) The increase in Clq observed in RA was not seen in systemic lupus erythematosus, chronic polyarticular gouty arthritis, ankylosing spondylitis, Paget's disease of bone, or Hodgkin's disease. Clq levels were determined both chemically (calculated) from the protein-bound hydroxyproline content of the euglobulin fraction) and by radial immunodiffusion. Although the estimates of Clq by these 2 methods did not agree, the increase of Clq in RA was found by the use of either method.

Adult↗