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N P Shilkina

Publications and source records attributed to N P Shilkina.

At least 19 recordsLinked to original sources
PubMed2007

Peripheral nervous system lesion syndromes and the mechanisms of their formation in connective tissue diseases.

Systemic rheumatological diseases are often accompanied by the development of central and peripheral nervous system pathology. Data providing evidence of the high incidence of peripheral nervous system lesions in systemic lupus erythematosus and systemic scleroderma are presented. These diseases in particular are characterized by polyneuropathies and tunnel syndromes. Our own observations, along with published data, revealed the following major pathogenetic mechanisms of peripheral nervous system lesions in diffuse connective tissue diseases - ischemic, immunological, and metabolic. Consideration of these mechanisms will lead to pathogenetically based treatment and improved therapeutic outcomes.

Connective Tissue Diseases↗
PubMed2005

[Clinical and laboratory markers of immune dysfunction in patients with rheumatoid arthritis and their blood relatives].

AIM: To ascertain clinical and laboratory signs of immune disorders in patients with rheumatoid arthritis (RA), their healthy blood relatives and healthy females without autoimmune disease family history. MATERIAL AND METHODS: Immune status was studied in 66 RA patients, their 56 female relatives of the first and 10 female relatives of the second degree of kinship, 63 healthy females without family history of autoimmune disorders. Immune response was assessed conventionally. RESULTS: 87.5% relatives of the first degree had symptoms of immune dysfunction (control--50.8%). Combinations of immunopathological syndromes were registered in 41.1% examinees of this group (control--17.5%). Autoimmune syndrome was most frequent (64.3%, control--19%). Infectious syndrome occurred in 51.8% relatives and 33.3% controls (the difference is significant). Despite immunosuppressive therapy, occurrence of infectious syndrome in RA (18.6%) was much lower than in controls. It was found that before RA onset 81.4% patients suffered from frequent long-term infections. RA onset reduced the infections frequency. Allergy was in 12.5, 19 and 6.2% of the relatives, controls and patients, respectively. The relatives demonstrated a significant decline of compliment activity close to such in patients. CONCLUSION: Immune disorders in blood relatives of women suffering from RA are more frequent and severe than in women without autoimmune disorders in family history. However, subclinical immunopathological symptoms in them did not realize in certain disease during the observation period. This may be explained by weaker congenital defects of immune system functioning or the existence of compensatory mechanisms suppressing development of pathological autoimmune processes.

Adult↗
PubMed2005

[Syndromes of peripheral nervous system lesions and mechanisms of their formation in disorders of connective tissue].

Systemic rheumatoid diseases are often concomitant with the development of central and peripheral systems pathologies. Presented are the results revealing high frequency of peripheral nervous system lesions (lupus erythematosus and systemic scleroderma), which characterized by polyneuropathy and tunnel syndromes. Based on the results of literature and own studies, pathological mechanisms of peripheral nervous system lesions in diffusion disorders of connective tissue were singled out as follows: ischemic, immunological and metabolic. Taking these mechanisms into account will permit to conduct pathogenetically valid therapy and to improve its results.

Connective Tissue Diseases↗
PubMed2005

[Systemic manifestations of rheumatoid arthritis, echostructural changes in brachiocephalic arteries].

AIM: To define echostructural and hemodynamic features of vascular lesions in rheumatoid arthritis (RA) with systemic manifestations. MATERIAL AND METHODS: Of 125 patients included in the study 70 had RA. They were compared to 40 patients with deforming osteoarthritis (DOA) and 15 patients with atherosclerosis of major cerebral arteries. Extra-articular systemic manifestations were diagnosed in 18 RA (25.7%) patients. Carotid, vertebral arteries and cerebral circulation were studied with ultrasonic duplex scanning on the unit "Vingmed system 5, Norway, 2002". RESULTS: The study group exhibited a significant reduction of linear perfusion velocity (LPV) with increased vascular resistance indexes in the carotids and vertebral arteries on the right and left. It was more evident in RA patients with systemic manifestations. Scanning carotids in RA with SM patients and RA patients without extra-articular manifestations showed differences suggesting that thickness of intima-media complex was larger when systemic manifestations were present. CONCLUSION: The revealed changes in circulation may indicate the systemic process.

Adult↗
PubMed2004

[Systemic vasculitis as an interdisciplinary problem].

Systemic vasculitis (SV) is characterized by generalized vascular bed lesion involving vessels of different sizes into a pathological process. The paper presents the results of a follow-up of 500 patients with different forms of SV, by making studies of immunity and the hemostatic system, angioscanning, Doppler ultrasound study of vessels, electrophysiological studies (rheoencephalography, encephalography), computed and magnetic resonance imaging of the brain, and visceral ultrasonography. A variety of clinical symptoms and involvement of different organs determine the interest of physicians of different specialties in the diagnosis and treatment of SV. The involvement of the nervous system in the process occurs in all forms of vasculitis, by afflicting the central, peripheral, and autonomic nervous systems with the development of regulatory and functional disorders. Lesions of the visual organ are typical of nonspecific aortoarteritis (Takayasu's disease), Wegener's granulomatosis, giant-cell arteritis. Recurrent uveitis is characterized in Behcet's syndrome. Cutaneous manifestations are included into the classification criteria of nodal polyartheritis, hemorrhagic vasculitis, and Kawasaki's disease. ENT and oral involvement are observed in Wegener's granulomatosis.

Arterial Occlusive Diseases↗
PubMed2001

[Stroke in rheumatic disease: risk factors].

The aim of this paper is to detect stroke risk factors in rheumatic diseases. The authors performed clinical and neurological investigations using MRI and CT tomography, ultrasound dopplerography, electrophysiological (reoencephalography, electroencephalography) techniques in 233 patients with rheumatic diseases. 197 patients (84.5%) presented cerebro-vascular disease, 93 (39.9%) of them had stroke. We divided all patients into two groups: group 1 included patients with "stroke at onset" (19%) and group 2 included patients with "delayed stroke" (21%). Patients with "stroke at onset" had such risk factors as vascular immune inflammation and unstable arterial hypertension. Patients with "delayed stroke" had such risk factors as hypercholesterolemia, stable arterial hypertension, asymmetric cerebral flow, hypercoagulation and vertebral syndrome.

Antibodies, Anticardiolipin↗
PubMed1999

[Cardiolipin antibodies in pregnancy of high risk].

Cardiolipin IgG and IgM antibodies (CAb) were studied in 116 cases of high-risk pregnancy. All the women were undergoing examination or treatment in regional perinatal center. CAb occurred more frequently in antenatal fetal death (50%). In blood hypertension, habitual abortions, history of infertility, gestational gestosis, CAb were encountered in 21.4, 20, 20 and 15.2% of cases, respectively. Intrauterine growth retardation was associated with CAb in 33.3% of cases. CAb occurred in pregnant women of different groups who had high uterine vascular resistance. The above findings indicate CAb contribution to genesis of gestational complications in high risk pregnancy.

Adolescent↗
PubMed1999

[Clinical significance of myeloperoxydase and proteinase 2 antibodies in patients with systemic lupus erythematosus].

Content of antibodies to neutrophil cytoplasma--myeloperoxidase (MPO)--and proteinase-3 (PR-3) was measured in the sera of 65 patients with SLE and 20 donors. Antibodies to MPO (a-MPO) and proteinase-3 (a-PR-3) significantly outnumbered those of the control. The number of a-MPO appeared elevated in 13, lowered in 7, moderate in 6 cases and directly correlated with anemia, pulmonary lesions, a-PR-3 level, inversely correlated with cerebrovasculitis and polyneuritis. The number of a-PR-3 was elevated in 14 cases (10 low titers and 4 moderate titers). High levels of both a-PR-3 and a-MPO were recorded in 8 sera. The content of a-PR-3 correlated directly with age of SLE onset but inversely with leukocyte count. Neither course of the disease nor inflammation activity were related to level of neutrophil antibodies. Factor analysis has identified groups of elements influencing the value of a-MPO and a-PR-3.

Acute Disease↗
PubMed1997

[Serum neopterin in hemorrhagic vasculitis].

Out of 12 patients with hemorrhagic vasculitis (HV) having the disease for 3-3.2 years (5 males and 7 females aged 18-55 years, mean age 34 +/- 13.8 years) renal affection was found in 3 (25%) patients. Renal function was normal in all the patients. One patient had nephrotic and two had mixed nephritis. One patient had gastrointestinal lesions. Serum neopterin was measured by radioimmunoassay. Mean concentration of serum neopterin was significantly higher than in donors (9.15 +/- 6.82 nmol/l and 5.2 +/- 2.1 nmol/l, respectively). A high neopterin level was found in 2 (67%) of 3 patients with nephritis and in 1(11%) of 9 patients free of nephritis. Mean neopterin was significantly higher in 3 patients with renal disorders than in the comparison group. A positive correlation existed between neopterin level and the clinical activity index, ESR, IgA, IgG CIC concentrations.

Adolescent↗
PubMed1997

[Clinical significance of Willebrand's factor antigen in patients with primary Sjogren's syndrome].

Concentration of von Willebrand's factor antigen (WFAg) was measured by solid phase enzyme immunoassay in the blood serum of 17 female patients (mean age 56.7 +/- 12.1 years) with primary Sjogren's syndrome (PSS) lasting, on the average, 4.1 +/- 1.5 years. Mean WFAg level in patients with PSS was equal to 2.56 +/- 1.4 IU/ml and exceeded significantly that of donors' (1.06 +/- 0.34, p < 0.001). In 9(53%) of 17 patients WFAg concentration was higher than normal (> 2.1 IU/ml). WFAg mean levels and frequency of its elevation did not differ significantly in patients with chronic parotitis, enlarged salivary glands, arthralgia/arthritis, lymphadenopathy, lung lesions, polyneuropathy and patients free of the above symptoms. In patients with myalgia, Raynaud's syndrome, skin vasculitis and vascular diseases WFAg concentrations were higher than in patients without them. There was no significant correlation between WFAg level and ESR, concentration of C-reactive protein, presence of rheumatoid and antinuclear factors.

Adult↗