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Biomedical subjects

N P Rosenthal

Publications and source records attributed to N P Rosenthal.

12 recordsLinked to original sources
PubMed1976

Familial neurological disease associated with spongiform encephalopathy.

In a family in whom susceptibility to neurological diseases was transmitted in autosomal dominant fashion, the diseases affecting different family members ranged from subacute and chronic dementias to various motor system abnormalities without dementia. The propositus suffered a typical clinical course of Creutzfeldt-Jakob disease. Neuropathological observations revealed spongiform encephalopathy. A first cousin had a chronic dementia; no spongiform changes were present at autopsy. Both patients had PAS-positive, eosinophilic plaques throughout the brain. Muscle biopsy of the propositus revealed some changes suggestive of "ragged-red" myopathy. The heterogeneity of disease and the inheritance pattern in this family suggests that general susceptibility to neurological disease is a genetic trait.

Adult↗
PubMed1976

Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish.

The kinetics of the membrane current during the anomalous or inward-going rectification of the K current in the egg cell membrane of the starfish Mediaster aequalis were analyzed by voltage clamp. The rectification has instantaneous and time-dependent components. The time-dependent increase in the K conductance for the negative voltage pulse as well as the decrease in the conductance for the positive pulse follows first-order kinetics. The steady-state conductance increases as the membrane potential becomes more negative and reaches the saturation value at about -40 mV more negative than the K equilibrium potential, V(K). The entire K conductance can be expressed by g(K).n; g g(K) represents the component for the time-independent conductance which depends on V-V(K) and [K+]o, and n is a dimensionless number (1 is greater than or equal to n is greater than or equal to 0) and determined by two rate constants which depend only on V-V(K). Cs+ does not carry any significant current through the K channel but blocks the channel at low concentration in the external medium. The blocking effect increases as the membrane potential is made more negative and the potential-dependent blocking by the external Cs+ also has instantaneous and time-dependent components.

Animals↗
PubMed1974

Efferent axons in the fish optic nerve and their effect on the retinal ganglion cells.

Recordings were taken from small bundles of axons dissected away from the otherwise intact optic nerve of the trigger fish, Hemibalistes chrysopterus. Proximal nerve stumps showed unitary activity of efferent axons which are activated by visual, vestibular, vibratory and tactile stimuli. Distal stumps showed predominantly the discharges of retinal ganglion cells which have a sustained response in either the light or dark and which are inhibited by the opposite condition. These retinal ganglion cells are also excited by vestibular, vibratory and tactile stimuli provided the optic nerve is almost intact. It is inferred that the excitation of the retinal ganglion cells by non-visual stimuli is effected by the centrifugal fibres mentioned above. Ablation of various lobes of the brain shows that the efferent fibres continue to respond after ablation of the frontal lobes and the cerebellum. The response is weakened by the ablation of the ipsilateral optic tectum and abolished when the contralateral tectum is removed.

Animals↗