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Biomedical subjects

N Otake

Publications and source records attributed to N Otake.

At least 73 records · Page 4Linked to original sources
PubMed1983

Studies on the biosynthesis of bialaphos (SF-1293) Part 3. Production of phosphinic acid derivatives, MP-103, MP-104 and MP-105, by a blocked mutant of Streptomyces hygroscopicus SF-1293 and their roles in the biosynthesis of bialaphos.

During biosynthetic studies on bialaphos to reveal the formation mechanisms of carbon-phosphorous bonds in detail, three new metabolites containing a H-P-C bond structure were isolated from the fermentation broth of a mutant of Streptomyces hygroscopicus SF-1293. Based on the spectroscopic analysis, the structures of these compounds have been determined as shown in Fig. 1. Transformation experiments of these metabolites to bialaphos suggested that the reduction of the phosphorous atom in phosphate will take place at an early biosynthetic stage.

Biotransformation↗
PubMed1983

A new family with beta-thalassemia intermedia.

In a Japanese family several members in three generations had, on hemoglobin analysis, typical findings of heterozygous beta-thalassemia. However, hemoglobin concentrations, red cell morphology, splenic size and clinical histories indicated that the disorder was more severe than in the usual beta-thalassemia trait. From the previous and the present studies folic acid supplements appeared to be beneficial in ameliorating the anemia. The findings may provide an apparent pathophysiologic and genetic explanations for the more severe anemia and red-cell abnormalities present in a small proportion of families with beta-thalassemia trait.

Hemoglobins↗
PubMed1983

Studies on biosynthesis of pentalenolactone. V isolation of deoxypentalenylglucuron.

Deoxypentalenylglucuron was isolated from the culture broths of three different strains, such as Streptomyces omiyaensis, S. albofaciens and S. viridifaciens. The structure of deoxypentalenylglucuron has been determined by 1H and 13C NMR, mass spectroscopy and by chemical correlation to be an oxidation product of pentalenene 1. Deoxypentalenylglucuron (1) has some antitumor activity against Sarcoma 180 in mice.

Animals↗