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Biomedical subjects

N Oka

Publications and source records attributed to N Oka.

At least 235 records · Page 13Linked to original sources
PubMed1983

[Postoperative regression speed of chronic subdural hematoma, with special reference to the subsequent study by CT xray].

Thirty-one adult patients with chronic subdural hematoma were treated surgically and followed Up by CT. In these cases, the postoperative regression of the hematoma cavity on CT was analysed in relation to patient's age, timing of operation, operative method, preoperative CT findings and postoperative clinical courses. In patients with older age and/or low density type of hematoma, slow reduction of subdural space was observed after operation. In five of these cases, the follow-up CT scans revealed reaccumulation of hematoma. Patients with high density type of hematoma and/or early operation from the onset showed a rapid reduction of hematoma cavity and clinical improvement.

Adult↗
PubMed1983

[Activities of phospholipase A1, A2, lysophospholipase and acylCoA: lysophospholipid acyltransferase in ischemic brain of the dog].

In this report, the sequential changes of phospholipase A1, A2, lysophospholipase and acylCoA: lysophospholipid acyltransferase activities in ischemic dog brain were investigated. The purpose of this study was to examine the enzymic changes of deacylation-reacylation cycle of biomembrane phospholipid in ischemia. Hemispheric non-blood supply models were produced by occlusion of main intracranial trunk arteries in dogs according to Suzuki's method. The sample was spooned out and frozen immediately with liquid nitrogen at the predetermined time. The assay of phospholipase A1, A2 and lysophospholipase activities was done by our method and acylCoA: lysophospholipid acyltransferase activity was according to Corbin and Sun's method. The activities of phospholipase A1, A2 and lysophospholipase did not show significant changes within 60 minutes after arterial occlusion. However these activities showed significant high value at 120 minutes and decreased gradually after then. On the other hand, acylCoA: lysophospholipid acyltransferase activity showed gradual decrease. These findings show that enzymic degradiation of acyl group of phospholipid in the brain is highest at about 120 minutes after complete ischemia. The importance of acyl groups of phospholipids for biomembrane structure and the function is well recognized. The turnover of these acyl groups in normal brain biomembrane is also well known. Some types of enzymic system related to this turnover has been investigated. Phospholipase A1, A2, lysophospholipase and acylCoA: lysophospholipid acyltransferase belong to these enzymic systems. There have been some reports that the content of free fatty acids in the ischemic brain increases in early stage.(ABSTRACT TRUNCATED AT 250 WORDS)

1-Acylglycerophosphocholine O-Acyltransferase↗
PubMed1983

[Copper needle insertion for the treatment of spontaneous carotid cavernous fistula].

Electrothrombosis by copper needle insertion was applied to three cases of spontaneous carotid cavernous fistula. These cases had been observed conservatively for about six months or more, but their symptoms did not improve. On angiogram, the feeding arteries were branches of both the ipsilateral internal and the external carotid artery. Frontotemporal craniotomy was performed and copper needles were inserted transdurally into the cavernous sinus. The closure of fistula was verified by intra-operative angiography in all cases and their symptoms improved after operation. However, postoperatively one case had transient third nerve palsy. Another case had Gerstmann syndrome due to narrowing of the internal carotid artery by one needle and the preoperative six nerve palsy became worse. In one case, the procedure could be uneventfully performed. Based on our experiences, several problems of this technique were discussed in this paper.

Arteriovenous Fistula↗
PubMed1982

[Sleep in vegetative state patients and recuperated cases from vegetative states (author's transl)].

Twenty-four hours polygraphic recording of EEG, electrooculogram and EMG were performed on 8 vegetative state patients and 4 recuperated cases, and the differences of the sleep pattern between two groups were discussed. It was difficult to divide the sleep pattern into normal four stages, because the frequency of EEG in vegetative state patients were very slow. So we divided it into the following 4 patterns; awake, shallow sleep, deep sleep and REM sleep. The sleep in vegetative state patients was interrupted by short duration and appeared at random during day and night. The amount of sleep in vegetative state patients increased proportion to severity of vegetative state. Rate of shallow sleep of them was high. REM sleep was seen in all the cases, but its cycle and lasting time were different in each case. The rate of shallow sleep prior to REM sleep was lower than normal pattern and the change of sleep state was atypical. Few hump and spindle wave appeared. For the reasons mentioned above, the sleep pattern in vegetative state patients was far from physiological sleep. On the other hand, the sleep in recuperated patients was more similar to the normal pattern than that of vegetative cases, but the rate of shallow sleep was as high as the vegetative cases. REM sleep was irregular and the change of sleep was also atypical. Therefore, the sleep pattern in recuperated patients was also far from physiological sleep, though it was better than that of vegetative cases.

Adult↗
PubMed1982

Construction of internal arteriovenous fistulas for hemodialysis using Inokuchi's vascular stapler.

Using Inokuchi's vascular stapler, arteriovenous fistulas with an end-to-end fashion for hemodialysis were constructed in 80 patients (82 limbs) with chronic renal failure. In 76 patients and 76 limbs (95%) of a total of 80 patients, the fistulas were patent and hemodialysis could be effectively carried out. Use of Inokuchi's vascular stapler facilitated a rapid construction of subcutaneous end-to-end arteriovenous fistulas, and no particular training in vascular surgery was required for the operator. Since the anastomosis was constructed in an end-to-end fashion, complications such as swollen hand, peripheral steal syndrome and cardiac failure were nil.

Arteriovenous Shunt, Surgical↗
PubMed1982

Long-term administration of prostaglandin E1: report of two cases with tetralogy of Fallot and esophageal atresia.

The authors continuously administered prostaglandin E1 (PGE1) iv to 2 infants with tetralogy of Fallot (TOF) and esophageal atresia with tracheoesophageal fistula (TEF) for more than 30 days, and observed side effects which could be attributed to the long-term administration of PGE1. After division of the TEF and anastomosis of the esophagus, leakage from the anastomosis developed in both cases. Because of the infectious foci in the thorax, Blalock's procedure was postponed and PGE1 was continued for 49 and 37 days. The authors believe radiographs of long bones and ribs demonstrated cortical hyperosteosis in both cases. Bone abnormalities became apparent approximately 30 days after the start of PGE1 and were associated with increases in serum alkaline phosphatase (peak value of about 2000 IU/L). Roentgenographic changes reverted toward normal and alkaline phosphatase values decreased after the cessation of PGE1 in both cases.

Alkaline Phosphatase↗
PubMed1981

[Superior Foville syndrome after clipping of basilar bifurcation aneurysm--case report (author's transl)].

The patient was a 48-year-old housewife, who had a sudden onset of severe headache followed by loss of consciousness for a few hours on the day of admission. Initially she showed slight restlessness due to headache, neck stiffness and subhyaloid hemorrhage. Four-vessel study revealed a basilar aneurysm on right retrograde brachial angiography and anterior communicating aneurysm on left carotid angiography. Two weeks after the onset, when she had no neurological deficit except for intermittent appearance of disorientation, both aneurysms were successfully clipped through right pterional approach of Yasargil. The subarachnoid hemorrhage was apparently due to basilar bifurcation aneurysm. Postoperatively, she showed right hemiparesis including her face, aniscocoria (left, 4 mm, oval: right, 1.5 mm, round) and conjugate deviation toward the left. The disturbance of conjugate eye movement and the hemiparesis completely disappeared in 2 and 7 days respectively. The patient was discharged 4 weeks postoperatively with mild left 3rd nerve palsy. At present, one year postoperatively, she is fully engaged in her housewife life without any neurological deficits. A case of superior Foville syndrome combined with Weber syndrome after clipping of basilar bifurcation aneurysm was reported and its anatomicoclinical mechanism was reviewed. The pathogenesis was supposed to be left midbrain ischemic lesion due to circulatory disturbance of P-1 perforators (P-1: proximal posterior cerebral artery); e.g., occlusion on clipping of vasospasm. This P-1 perforator syndrome after aneurysmal clipping has been reported only little. The importance of preservation of these perforators with careful dissection and manipulation under microscopy was emphasized.

Basilar Artery↗
PubMed1981

[A case of hematoma localized to midbrain tegmentum following closed head injury (author's transl)].

UNLABELLED: CASEs of primary brain stem lesion following closed head injury, verified on CT scan, have been increasingly reported recently. However, most of them have supratentorial lesions in addition to brain stem, resulting in a poor outcome. In this paper, a case of localized brain stem hematoma following closed head injury, is reported based on CT findings. CASE: A 26-year-old man slipped down on his back and hit the right occipital area with following loss of consciousness for several minutes. Since then, he continued to have gait disturbance and visited our hospital on the next day. On admission, he presented truncal ataxia, left trochlear nerve palsy, right Horner's syndrome and left hemihypesthesia. CT scan revealed a small hematoma localized to the right midbrain tegmentum at the level of inferior colliculus, well correlating with his clinical presentation. He gradually improved on conservative treatment and returned to his former work one month after the accident. This case suggests that there may be cases of primary brain stem injury with no other intracranial lesion based on CT findings and with a good prognosis. Shear strain is said to be a probable mechanism for explaining brain stem injury, which is usually combined with other parenchymal lesions. In our case, however, more focal factor--nervous and/or vascular compression against the tentorial edge--is suspected for producing this localized midbrain lesion.

Adult↗
PubMed1980

A case of a developmental anomaly of the femoral artery: persistent sciatic artery.

A case of a persistent sciatic artery in a 68-year-old farmer, showing symptoms of acute arterial occlusive lesion of the right lower limb is presented. The persistent sciatic artery was joined to the internal iliac artery proximally and to the popliteal artery distally. The anomalous artery was occluded by atheromatous thrombi. The superficial femoral artery was hypoplastic and terminated in the descending genicular artery at the midthigh level. A successful bypass was performed between the common femoral artery and proximal popliteal artery utilizing a woven teflon graft.

Acute Disease↗
PubMed1980

DNA damage induced with near-ultraviolet light irradiation in the presence of quinoxaline-1,4-dioxide.

When Bacillus subtilis transforming DNA was irradiated with near-ultraviolet light in the presence of quinoxaline-1,4-dioxide, the activity of DNA decreased rapidly. This loss of activity was ascribed to damages on DNA that lead to chain cleavages of the molecule. A feature of this phototoxic action of the reagent is that it takes place in nitrogen atmosphere and is inhibited by oxygen.

Bacillus subtilis↗