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Biomedical subjects

N Ohba

Publications and source records attributed to N Ohba.

At least 163 records · Page 9Linked to original sources
PubMed1981

Congenital hereditary retinoschisis: evolution at the initial stage.

Two male infants with congenital hereditary retinoschisis are presented. The disease was detected when they were 11 and 20 months old, respectively, and they were followed up during the subsequent months. Initially, they both revealed a tremendously elevated retinoschisis lesion in both equatorial an peripheral retina, which was associated with foveal retinoschisis. The peripheral ballooning retinoschisis regressed gradually in the following months, and a relatively flat retinoschisis was left. It was proposed that the early stage of the disease is characterized by a bullous retinoschisis followed by its spontaneous regression during the first several years of life. A survey of the literature favors our view.

Child, Preschool↗
PubMed1981

Primary vitreoretinal dysplasia transmitted as an autosomal recessive disorder.

A sibship of a brother and sister with congenital bilateral pseudoglioma is described. The most prominent abnormality was a greyish-white vascularised mass in the retrolental spaces, which was noted as early as the first weeks of life. Corneal opacities, posterior synechiae, and complicated cataracts developed within 1 to 2 years age. The sibship showed normal chromosomes and had no systemic disorders, including mental and hearing impairment. The parents and other relatives were normal. Autosomal recessive disease, rather than Norrie's disease, was the most probable explanation for the dysplasia of the vitreous and retina in the sibship. This is probably the third report of familial occurrence with autosomal recessively inherited vitreoretinal dysplasia without systemic anomalies. The importance of the disease in genetic counselling is discussed.

Blindness↗
PubMed1980

Blood staining of the cornea in Hansen's disease. A light- and electron-microscopic study.

Blood staining of the cornea was studied by light and electron microscopy: a 55-year-old male with Hansen's disease had blood staining of the cornea due to intracorneal hemorrhage; he received a partial-thickness keratoplasty following 1 year after the onset of the staining. The excised specimens revealed deposits of degraded erythrocytes in the stroma. Numerous dense granules, probably of erythrocytic breakdown products, were phagocytosed by macrophages as well as parenchymal cells. The presence of macrophages was limited to the middle part of the stroma in which newly formed vessels were remarkable.

Cornea↗
PubMed1979

Effects of topically applied bupranolol on the intraocular pressure. Effects on the untreated eye.

Topically applied bupranolol, a beta-adrenergic blocking agent, has been shown to have a marked effectiveness in lowering the intraocular pressure of the normal and glaucomatous eyes. The effects were not only seen in the treated eyes but also in the untreated, contralateral eyes. The contralateral response was independent of the ongoing diurnal variation of the intraocular pressure. Instillation of the drug into the nasal cavity induced decrease of the intraocular pressure in both eyes, the extent of which was comparable to the contralateral response induced by ocular instillation. These observations suggest that the contralateral response is caused by systemically absorbed drug, probably due to the action on the central locus regulating the intraocular pressure. Instillation of pilocarpine did not show any similar contralateral response.

Absorption↗
PubMed1977

[Investigations on retinopathia pigmentosa. Statistical analysis of perimetry results (author's transl)].

Kinetic perimetry was carried out using the Goldmann perimeter in 201 patients with primary pigmentary retinal dystrophy, 156 autosomal recessive and 45 autosomal dominant cases. "The advanced stage" of the isopter deterioration was defined as the isopter area with the test object I-4 being 1 cm2 or less on the chart of Goldmann. The frequency of "the advanced stage" cases in creased with age in both hereditary forms, but it was higher in the recessive than in the dominant form throughout all age groups. The frequency-age relationship was exponential as is found in various aging phenomena. Fifty per cent of the patients were in "the advanced stage" at the age of 30 years in the recessive and at the age of 56 years in the dominent form.

Adolescent↗
PubMed1976

Unilateral colour vision defect resembling tritanopia.

A case of unilateral tritan defect is described. Colour-naming experiments showed that the tritanopic eye could perceive multiple colour hues. Although the defect resembled congenital tritanopia, it was considered to be acquired secondary to retinal pathology.

Adult↗