Search PubMed⌕ Search

Biomedical subjects

N O'Connor

Publications and source records attributed to N O'Connor.

At least 55 records · Page 3Linked to original sources
PubMed1988

Low intelligence and special abilities.

In summary, our research enables us to conclude that specific talents are found in people who differ widely in general intelligence levels and such talents should therefore be regarded as at least partly intelligence-independent. However, between normal and mentally handicapped populations and even within the idiot savant group, general cognitive capacity plays some part in determining the manner in which talents manifest themselves. Idiot savant special abilities can neither be regarded as the sole consequence of practice and training, nor are such skills based only on an efficient rote memory. Instead, idiots savants use strategies which are founded on the deduction and application of rules governing the material upon which their special ability operates. They also generate novel or new examples of such rule based structures just as we do in our use of language. Because of the much greater prevalence of idiots savants in the autistic than in the mentally handicapped population, some characteristic common to both autism and specific giftedness might be assumed. An obsessional pre-occupation with a limited section of the environment might be a common factor to both. It may be this rather than autism itself which is relevant to the idiot savant phenomenon.

Aptitude↗
PubMed1987

Visual and graphic abilities of the idiot savant artist.

Five idiots savants whose artistic output was judged to be at art school entrance standard were matched for performance and verbal IQ with control subjects who had no special artistic talent. Each subject was given tests of reproductive skill with both concrete pictures and unfamiliar and unnameable geometric designs. They were also asked to draw a man, and a test of picture completion was given which involved constructive imagination. In all tests the idiots savants proved clearly superior to IQ-matched controls, indicating the presence of an IQ-independent talent. The results are interpreted in terms of a superior image memory and ready access to a 'picture lexicon'. In addition, the existence of superior graphically directed motor programmes must be assumed.

Adult↗
PubMed1987

Musical inventiveness of five idiots-savants.

Accounts of musical ability in idiots-savants have up till now been confined to stressing the astounding musical memory which such persons may possess. The present study investigates compositional and improvisational skills in five idiots-savants. The findings interpreted as indicating that a representational system of musical rules and structures is accessible to persons of low general intelligence, and that such a system may underlie reproductive as well as generative musical capacity.

Adolescent↗
PubMed1987

Cognitive psychology and mental handicap.

The psychology of mental handicap has been influenced by two traditions in general psychology, pychometric measurement following Binet and experimental psychology first initiated by Wundt. The weakness of the former is its lack of explanatory power and, of the latter, its lack of sound alignment with the neuropathology of mental handicap. A closer association of experimental psychology and neuropathology might help us to reframe our concepts of intelligence, cognitive functions and their handicaps.

Education of Persons with Intellectual Disabilitie↗
PubMed1987

Visual memory and motor programmes: their use by idiot-savant artists and controls.

Artistically gifted children of normal intelligence and idiot-savant artists as well as two groups of IQ-matched controls were tested for their perception of and recognition memory for shapes. They were also tested for their capacity to graphically reproduce the shapes on sight (copying) or from memory. The material consisted of designs of two levels of complexity and structure. Results showed that while IQ was the determining factor in matching and recognition performance, copying and reproduction ability depended on artistic ability and was independent of level of intelligence. These results are interpreted in terms of access to an intelligence-independent system of graphic representations which can evoke appropriate motor programmes.

Adolescent↗
PubMed1986

Idiot savant calendrical calculators: rules and regularities.

The three experiments described aimed to establish whether the achievements of idiot savant calendrical calculators were based solely on rote memory and arithmetical procedures, or whether these subjects also used rule-based strategies. It was found that, although different structural calendar regularities were tested by using differing experimental paradigms, all subjects could at least use some of the rules under investigation. The more cognitively able subjects could make use of all the three structural regularities of the calendar tested here. It was concluded that idiot savant calendrical calculators can use rule-based strategies to aid them in the calculation of the days on which past and future dates fall.

Adolescent↗
PubMed1986

A prospective study of acute hypoxic respiratory failure.

A prospective study of acute hypoxic respiratory failure was carried out by nine centers in a collaborative NIH study from 1 September 1975 to 1 March 1977. Serious hypoxic respiratory failure was defined in 713 patients by the presence of (1) endotracheal intubation and positive airway pressure for at least 24 hours, and (2) the administration of at least 50 percent oxygen. The 490 patients between 12 to 65 years of age had a mortality of 61 percent. Mortality increased with increasing organ failure: one organ system failure (lung only) 40 percent; two, 54 percent; three, 72 percent; four, 84 percent, five, 100 percent. Only 103 patients died with isolated lung failure, whereas 353 died of a combination of lung and other organ failures. Both the overall mortality (66 percent) and the mortality of those with only isolated lung failure (40 percent) were much higher than anticipated for the selection criteria.

Acute Disease↗
PubMed1985

The psychosexual histories of young women with bulimia.

While it is known that anorexia nervosa patients show a wide range of sexual knowledge, attitudes and practices, the psychosexual histories of bulimia patients have not been studied. In this paper the psychosexual histories of 20 bulimic patients and 20 matched control subjects are presented. Bulimic patients were more likely to experience orgasm with masturbation, were more likely to have experimented with anal intercourse, and were more likely to describe their libido as 'above average.' Control subjects were more likely to experience orgasm during sexual intercourse. Bulimic patients associated high body weights with unattractiveness, and tended to withdraw from social and sexual activity at high weights. In other aspects of their sexual behaviour, and in their attitudes to sexual matters, the two groups were similar.

Adolescent↗
PubMed1985

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.

Ki-1 is a monoclonal antibody (raised against a Hodgkin's disease-derived cell line) that, in biopsy tissue affected by Hodgkin's disease, reacts selectively with Reed-Sternberg cells. The expression of Ki-1 antigen has been analyzed by immunocytochemical techniques in a wide range of human tissue and cell samples, including fetal tissue, malignant lymphomas (290 cases), and mitogen- and virus-transformed peripheral blood lymphocytes. The antigen was detectable on a variable proportion of cells in all cases of lymphomatoid papulosis and angio-immunoblastic lymphadenopathy and in 28% of the cases of peripheral T cell lymphomas (including lympho-epithelioid lymphomas). It was also expressed (more strongly) on tumor cells in 45 cases of diffuse large-cell lymphoma, most of which had originally been diagnosed as malignant histiocytosis or anaplastic carcinoma, because of their bizarre morphology. However, all of these cases lacked macrophage and epithelial antigens. Thirty-five cases expressed T cell-related antigens (associated in nine cases with the coexpression of B cell-related antigens), seven bore B cell-related antigens alone, and three were devoid of T and B cell markers. DNA hybridization with a JH specific probe showed a germline configuration in 11 cases of T cell phenotype, in two cases lacking T and B cell antigens, and in one case of mixed T/B phenotype, while rearrangement was found in two cases of clear B cell type and in one mixed T/B case. Expression of the Ki-1 antigen could be induced, together with interleukin 2 (IL 2) receptor, on normal lymphoid cells of both T and B cell type by exposure to phytohemagglutinin, human T leukemia viruses, Epstein-Barr virus, or Staphylococcus aureus. The results obtained indicate that Ki-1 antigen is an inducible lymphoid-associated molecule that identifies a group of hitherto poorly characterized normal and neoplastic large lymphoid cells. Tumors comprised solely of these cells show both morphological and immunological similarities to the neoplastic cells in Hodgkin's disease. This suggests that both disorders represent the neoplastic proliferation of activated lymphoid cells of either T cell or, less commonly, B cell origin. Disorders in which only a minority of cells express Ki-1 antigen (lymphomatoid papulosis, angio-immunoblastic lymphadenopathy, and certain T cell lymphomas) probably represent lesions in which only some of the abnormal cells have transformed into an "activation state." In direct support of this view is the finding that the Ki-1 expression in these lesions is accompanied by the expression of HLA-DR and IL 2 receptors.

Adolescent↗
PubMed1984

Idiot savant calendrical calculators: maths or memory?

Eight idiot savant calendrical calculators were tested on dates in the years 1963, 1973, 1983, 1986 and 1993. The study was carried out in 1983. Speeds of correct response were minimal in 1983 and increased markedly into the past and the future. The response time increase was matched by an increase in errors. Speeds of response were uncorrelated with measured IQ, but the numbers were insufficient to justify any inference in terms of IQ-independence. Results are interpreted as showing that memory alone is inadequate to explain the calendrical calculating performance of the idiot savant subjects.

Adolescent↗
PubMed1983

Peripheral and central handicap and encoding.

A linear model of information processing led to many experiments on learning difficulties in the subnormal and severely subnormal. It assumes learning can result from a break in the chain of information flow at any point but overlooks compensatory mechanisms common to a developing organism. To compensate for the model's difficulties, we compared blind and deaf children with subnormal and subnormal autistic children (i.e. localized with general cognitive incapacities). Absence of a modality led to alternative encoding strategies, but in certain circumstances they also occurred in the centrally handicapped. Reasons for the similarities and differences are discussed.

Adolescent↗