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Biomedical subjects

N O Salako

Publications and source records attributed to N O Salako.

At least 19 recordsLinked to original sources
PubMed2005

High frequency of isolation of antibiotic-resistant oral Viridans streptococci from children in Kuwait.

Antimicrobial resistance among the Viridans group of streptococci (VGS) has emerged as a hindrance to effective antibiotic therapy. Our objective was to evaluate the prevalence of antibiotic-resistant VGS in healthy children. Plaque samples were collected from tooth and tongue surfaces of 102 healthy subjects. Serially diluted samples were inoculated onto BHI agar plates and Mitis Salivarius Agar (MSA) plates and incubated as appropriate. Representative colonies were identified to species level by standard methods. Susceptibility of the VGS was performed by determining the minimum inhibitory concentrations (MICs) of 11 antibiotics using Etest. Of the 540 VGS isolates from both sites, 58% were from the tooth surfaces and 42% from the tongue. The most prevalent were S. salivarius (21.5%) and S. sanguis (16.3%). Imipenem and vancomycin had excellent activities. Resistance rates to trimethoprim, amoxicillin, piperacillin, erythromycin, cefuroxime and cephalothin, were 60.7, 40.8, 34.7, 32.6, 27.5 and 25.3%, respectively. Resistance rates to penicillin and clindamycin were 15.9% and 15.4%, respectively. The majority of the erythromycin-resistant isolates were from the tongue; 41% versus 29%. At the species level, 26% and 23% of S. salivarius and 23% and 14% of S. mutans from the tooth and tongue, respectively were resistant to penicillin. The data show species-related and site-related variations in the susceptibility pattern and an emerging high prevalence of antibiotic-resistant VGS. The difference in the susceptibilities between the species underscores the importance of accurate-identification and the need for surveillance of antimicrobial resistance among clinical isolates in our hospitals.

Anti-Bacterial Agents↗
PubMed2004

Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait.

OBJECTIVES: The use and abuse of antibiotics have been of concern to the medical and the dental profession for sometime now, due mainly to the emergence of antibiotic-resistant bacteria. The objective of this project was to determine the rationale and the pattern of antibiotic prescription for dental management in Kuwait. METHODS: A questionnaire was distributed to 200 dental practitioners working in the Ministry of Health dental centers in Kuwait. The questionnaires sought answers to the clinical and non-clinical factors; signs, clinical conditions and dental treatment modalities for which the practitioners would prescribe antibiotics. RESULTS: Of the 200 questionnaires sent out, 168 (84%) respondents returned fully completed forms. A total of 107 (63.7%) of the respondents were males. Of respondents, 90% would prescribe antibiotics for patients with elevated body temperatures and evidence of systemic involvement, gross or diffuse facial swelling and closure of the eye due to inflammatory swelling. However, over 50% would prescribe antibiotics for cases with localized fluctuant swelling without any systemic involvement, while 59.6% would prescribe for patients with difficulty in swallowing as a result of an oral infection. Many respondents would consider antibiotic prescription for routine dental extraction, and for non-clinical reasons such as uncertainty of diagnosis, convenience, expectation of the patient and lack of time to treat immediately. Amoxicillin was the most frequently prescribed antibiotic. Higher knowledge regarding adequate indications for antibiotic use was associated with longer professional experience. CONCLUSIONS: The results of this analysis suggest that there is lack of uniformity in the rationale for antibiotic use among dental practitioners in Kuwait. There is an urgent need for the formulation of evidence-based guidelines, which should take into account the peculiar behavioral characteristics of the community.

Adult↗
PubMed1998

Prevalence of the Carabelli trait in Saudi Arabian children.

This study was carried out to evaluate the prevalence of trait of Carabelli in Saudi Arabian children. 250 children, aged 7 to 10 years were examined. The criterion of inclusion was caries free maxillary second deciduous and first permanent molars. The prevalence of the trait was 58.7% with almost similar distribution between males and females. The tubercular variety was the commonest type, which was significantly more in males than females. The frequency of the trait was similar to that of Malaysians but less than for other population groups.

Chi-Square Distribution↗
PubMed1998

Temporomandibular disorders among school children.

A large volume of literature is available on the Temporomandibular Disorders (TMD) in adults. However, relatively little information is available on this condition in children. The present study is aimed at providing a comprehensive survey on Temporomandibular Joint Status in Saudi Arabian Children in the Western Region of the Kingdom. This is a report on the prevalence of TMDs in children. Five hundred and two children aged 3-7 years old were examined for signs and symptoms of TMDs in a classroom setting. Eighty-three (16.53%) presented with TMDs, with 34 (14.46%) males 49 (18.35%) female (This difference between sexes is significant P < 0.001); 39 (7.8%) of the children had TMJ sounds; 34 (6.77%) had associated muscle tenderness; 13 (2.59%) had pain during TMJ movement; 17 (3.39%) had deviation of the mandible during movement; and 9 (1.7%) had a restricted mouth opening. There is a general tendency for these signs and symptoms to be more significantly prevalent in females. None of the children had sought dental treatment for these conditions. The importance of TMJ examinations in the overall clinical assessment of the pediatric patient should not be overlooked. Identifying this subject early in life would allow us to follow up the patient and intervene in the appropriate time to avoid future problem in the TMJ apparatus.

Age Distribution↗
PubMed1996

Caries experience of children aged 6-9 years in Jeddah, Saudi Arabia.

This study was conducted to examine the caries experience of children aged 6-9 years in Jeddah, Saudi Arabia. Overall, 1522 children were examined from six primary schools located in different areas of the city. Results showed that the mean dmft and DFT were 4.23 and 1.85, respectively. The mean dmft and DFT values excluding caries-free children, however, were 5.71 and 2.95, respectively. Only 26.1% of the children were caries free. There was a high proportion of untreated dental caries and most of the carious teeth were treated by extraction. The need for effective preventive measures was stressed.

Age Distribution↗
PubMed1995

Oral findings in a child with Prader-Labhart-Willi syndrome.

This case report highlights the dental implications of some features of Prader-Labhart-Willi syndrome. A 5-year-old child with this syndrome presented with a severe form of dental caries. The need for early dental consultation and preventive dental procedures is stressed.

Child Behavior Disorders↗
PubMed1994

Effect of aqueous extract of miswak on the in vitro growth of Candida albicans.

Chewing sticks (miswak) which are the roots of Salvadora persica plant have been used for centuries as oral hygiene tools in many parts of the world particularly in Saudi Arabia. Many studies have demonstrated the antiplaque, antiperiopathic, anticaries and antibacterial effect of these sticks. This study was designed to investigate the antimycotic effect, if any, of the aqueous extract of the plant roots. Various concentrations of aqueous extract of miswak prepared with Sabouraud medium were inoculated with Candida albicans (oral isolate). These were incubated at 37 degrees C and the turbidity was determined by OD at 600 nm wavelength measured at specific intervals over a period of 48 h. Data show that the extract at a concentration of 15% and above, has a fungistatic effect for up to 48 h. This antimycotic effect was probably due to one or more of the root contents which included chlorine, trimethylamine, and alkaloid resin, and sulphur compounds.

Antifungal Agents↗
PubMed1992

Comparison of the effects of galactose and glucose on the pH responses of human dental plaque, salivary sediment and pure cultures of oral bacteria.

Comparisons made in dental plaque in vivo demonstrated that galactose produces a significantly smaller decrease in pH than does glucose. In vitro studies with plaque, salivary sediment and pure cultures of oral bacteria done in the absence of intraoral factors such as flowing saliva confirmed this lesser acidogenicity of galactose. Pure culture showed that most of the bacteria tested produce a moderate to large decrease with glucose but only a few do so with galactose; most produced a moderate to little or no pH response with this sugar. This suggested that the smaller decreases in pH seen in plaque in vivo with galactose were largely due to bacterial differences, basically that resident micro-organisms individually have less galactolytic than glucolytic capability. Variance in capability was attributed to differences in membrane transport processes and metabolic pathways normally available to bacteria for galactose and glucose catabolism. In the in vitro experiments, because plaque and sediment can produce base as readily as they can produce acid, the nitrogenous substrates identified earlier as major stimulants of base formation, urea and arginine, were concurrently examined for their attenuating effects on the galactose and glucose pH responses. These showed, consistent with its lesser acidogenicity, that galactose could be countered more readily in its ability to reduce the pH by either of these two base-forming substrates than could glucose. The effects were different with urea and with arginine, urea attenuation occurred sooner and arginine attenuation later in both plaque and sediment. The corresponding acid-base pH profiles for pure cultures were different.(ABSTRACT TRUNCATED AT 250 WORDS)

Actinomyces↗
PubMed1990

Distribution of oral tumors in Nigerian children based on biopsy materials examined over an 11-year period.

A survey of biopsied lesions of patients aged 0-16 yr who presented with oral swellings at the Lagos University Teaching Hospital over a period of 11 yr was conducted to determine the pattern of presentation of these lesions in 203 Nigerian children, 123 boys and 80 girls. 21% of the lesions were fibro-osseous lesions. There were more non-odontogenic than odontogenic tumors and very few salivary gland tumors.

Adolescent↗
PubMed1989

Incidence of selected ureolytic bacteria in human dental plaque from sites with differing salivary access.

Saliva is the main source of urea in the human mouth and may be responsible for the predilection of ureolytic bacteria for certain tooth sites. As a test of this hypothesis, the ureolytic bacteria, Haemophilus parainfluenzae, Actinomyces naeslundii, Actinomyces viscosus and coagulase-negative oral staphylococci, were enumerated in supragingival plaque from various sites in each of 10 subjects. The sites sampled included the maxillary and mandibular incisors (chosen because the lower incisors are more exposed to the submandibular-sublingual secretion than the upper) and the maxillary and mandibular molars (the upper molars being closer to the source of parotid saliva). After dispersion of the plaque samples in saline, subsamples of each suspension were plated on appropriate selective media and other subsamples were taken for nitrogen analysis to measure the amount of plaque sampled. H. parainfluenzae that used urea was present in the largest numbers, A. viscosus was next and A. naeslundii and coagulase-negative staphylococci were least. The staphylococci and H. parainfluenzae were more numerous from mandibular than from maxillary incisors and from maxillary than mandibular molars, a pattern which suggests that salivary access favours their selection. The numbers of A. viscosus and A. naeslundii were not related to salivary access: A. viscosus was most numerous from the maxillary incisors, possibly because this site is normally the most acidic of the four studied and A. viscosus is strongly acidogenic and aciduric; the incidence of A. naeslundii had no relationship with site.(ABSTRACT TRUNCATED AT 250 WORDS)

Actinomyces↗