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N Nikolić

Publications and source records attributed to N Nikolić.

At least 19 recordsLinked to original sources
PubMed2003

Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime.

The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)(2) and formation of mixed ternary complex. The optimal mole ratio of Cu(II):l-DM-PhA is 1:4, the pH should be between 4.1 and 4.2 and up to 0.8 mM of triethylamine is added for column presaturation with the initial complex. The elution order has been defined using isolated l-HM-PAO via l-HM-PAO L(+)tartrate and meso-HM-PAO obtained by repeated recrystallization from the isomeric mixture of HM-PAO. Complete resolution between all isomers (R(S) from 2.14 to 3.91) and partial resolution for meso(EE)/l-HM-PAO (R(S)=0.83) has been obtained. This means that the proposed chiral ligand-exchange chromatography (CLEC) can be used for determination of the isomeric purity of HM-PAO. This as an alternative method for resolution measurements with chiral columns.

Butanones↗
PubMed2001

Viewpoint--Travel medicine and maritime medicine.

Although travel medicine and maritime medicine study health problems of different populations of travelers, they have many common interests. Seafarers are a special kind of travelers and for them traveling is the essential part of their professional lives, so the health risks during travel are basically the risks of their profession and their working environment. In this paper similarities and differences between the practice of work in these two specialities of medicine are presented and discussed.

Global Health↗
PubMed1992

Health care for nautical tourist.

Nautical tourism is one of the developing branches of tourism in Europe. It differs from other forms of tourism. Conditions under which nautical tourists live are similar to those of seamen employed on vessels in costal shipping. The health care for nautical tourists should be organized according to the principles of health care for crews of merchant ships engaged in constal shipping.

Emergency Medical Services↗
PubMed1990

Ship's medicine chest on Yugoslav ship.

An insufficient medical care during sea voyage presents a great risk for the health and life seafarers at sea. Apart from an appropriate education of seamen, radio-medical services, and a good medical guide, ship's medicine chest is an important component of the primary health care on ships. The standardization and unification of these medicine chests, which all major maritime countries except Yugoslavia have already accepted, is essential. The authors present a proposal for the standardization of the list of drugs carried on Yugoslav ships.

Naval Medicine↗
PubMed1990

[Hypoglycemia in childhood. I. Physiology, pathophysiology and the classification of hypoglycemia].

Regardless of age and body mass, hypoglycemia is defined as the glycemia value below 2.6 mmol/l. This is the borderline glycemia value, below which the suffering begins which directly endangers the CNS development in the newborn period. The fact that we registered hypoglycemias in 2/3 of premature infants and in 3/4 of low birth weight infants at registration on the ward for premature infants at the Institute for Mother and Child Health Protection, in the course of 1988, tells of the complexity and seriousness of the situation with which we meet during the depopulation of the inhabitants. The paper gives physiological basics for the understanding of glucose homeostasis in the organism, as the most frequent forms of hypoglycemia with which the physician meets in practice. A diagnosing and hypoglycemia treatment algorithm is given.

Child↗
PubMed1990

[Hypoglycemia in childhood. II. Clinical aspects and therapy of hypoglycemia in childhood].

Regardless of age and body weight, hypoglycemia is defined as the glycemia value below 2.6 mmol/l. This is the borderline glycemia value, below which the suffering begins which directly endangers the CNS development in the newborn period. The fact that we registered hypoglycemias in 2/3 of premature infants and in 3/4 of low birth weight infants at registration on the ward for premature infants at the Institute for Mother and Child Health Protection, in the course of 1988, tells of the complexity and seriousness of the situation with which we meet during the depopulation of the inhabitants. The paper gives physiological basics for the understanding of glycose homeostasis in the organism, as the most frequent forms of hypoglycemia with which the physician meets in practice. A diagnosing and hypoglycemia treatment algorithm is given.

Child↗
PubMed1979

[Evaluation of certain hemostasis parameters in premature infants].

In order to evaluate the specificity of hemostatic mechanism in premature Infants, the following examinations of coagulation and fibrinolytic parameters have been done: platelet number, concentrations of fibrinogen prothrombin, factors V, VII X, X, VIII, IX and XIII, antithrombin III, plasminogen, euglobulin lysis time, fibrin degradation products, alpha-1 antiplasmin and alpha-2 macroglobulin. The examinations have been done in the whole of 18 premature infants of both sexes. The obtained results show that lowered level of coagulant activity was not exclusively the consequence of low activity of vitamin-K dependent factors, but the result of more complex disorders partly connected with the transient reduction of factors VIII, XIII and fibrinogen. The total fibrinolytic activity, in the meantime, was of the normal intensivity. The established disorder of coagulation-fibrinolytic balance probably represents the certain contributing factor in more frequent occurrence of haemorrhagic syndrome in premature infants.

Antithrombins↗
PubMedDate not supplied

Sailing safely.

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Humans↗