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Biomedical subjects

N Nelson

Publications and source records attributed to N Nelson.

At least 307 records · Page 17Linked to original sources
PubMed1968

A novel apical corpuscle in hypahe of Mucor rouxii.

Median longitudinal sections of germ tube apices of Mucor rouxii revealed the presence of a single, roughly hemispherical, electron-dense organelle, in intimate contact with the apical cell wall. Conceivably, this "apical corpuscle" may be responsible for the emission of the germ tube and its continued apical growth.

Microscopy, Electron↗
PubMedDate not supplied

Laminar air flow isolation and decontamination: a prospective randomized study of the effects of prophylactic systemic antibiotics in bone marrow transplant patients.

122 patients with hematologic malignancies underwent allogeneic marrow transplantation from HLA-matched sibling donors and received one of two forms of infection prophylaxis while granulocytopenic: 1) decontamination and laminar air flow isolation (LAF, 68 patients), and 2) LAF plus prophylactic systemic antibiotics (LAF + PSA, 54 patients). Patients were evaluated for infection acquisition while in isolation. Septicemia occurred in 11 (16%) of the patients in the LAF group and in three (6%) patients in the LAF + PSA group. Fourteen (21%) of the patients in the LAF group and four (7%) patients in the LAF + PSA group had a major local infection. There was no difference in the incidence and severity of graft-versus-host disease or incidence and duration of fever. The addition of prophylactic intravenous broad-spectrum antibiotics for patients isolated in LAF rooms significantly decreased infection acquisition.

Adolescent↗
PubMedDate not supplied

The effects of infection prevention regimens on early infectious complications in marrow transplant patients: a four arm randomized study.

Three hundred and forty-two patients with hematological malignancies underwent allogeneic marrow transplantation from family donors and were allocated to receive 1) no specific infection prophylaxis in a conventional hospital room (control, 100 patients), 2) prophylactic systemic antibiotics (PSA) in a conventional hospital room (PSA group, 101 patients), 3) decontamination and isolation in a laminar air flow (LAF) room (LAF group, 65 patients) and 4) PSA in an LAF room (LAF+PSA group, 76 patients). Patients were studied for bacterial and fungal complications from the day of admission and until engraftment. LAF isolation was discontinued before engraftment in 27% (LAF+PSA group) to 32% (LAF group) of isolated in 26% (LAF+PSA group) to 27% (PSA group) of patients on prophylactic antibiotics. Septicemia occurred in 41%, 22%, 25% and 10% of patients in the control, PSA, LAF and LAF+PSA group, respectively. The incidence of septicemia was significantly less in the LAF+PSA group than in the control and LAF group with the incidence of septicemia significantly higher in the control group than in any of the other three groups. No other risk factors analyzed in proportional hazards regression tests were associated with septicemia acquisition. It is concluded that effective infection prevention modalities significantly reduce infection morbidity in transplant patients. Since most granulocytopenic transplant patients not receiving PSA will receive empiric or therapeutic broad spectrum antibiotics. The use of PSA in or out of LAF isolation is recommended as an effective modality to reduce septicemia acquisition.

Adolescent↗
PubMedDate not supplied

Patient and staff views of factors influencing assaults on psychiatric hospital employees.

This study compares the viewpoints of psychiatric hospital employees and patients as to situational and interactional factors that are related to patient assaults on staff. Sixty-nine patients from eight high-assault wards in two state psychiatric hospitals were interviewed to identify hospital practices and aspects of the physical environment that they believed to be related to assaultive behavior. One hundred thirty-seven nursing staff members on the same wards were surveyed. Patients and staff had many concerns in common, including restrictions on patient smoking and access to the outdoors, staff clinical skills and patients' being treated with respect, and the use of seclusion and restraint on the wards. Additionally, patients were concerned about rules not being explained. Staff believed that the single most important issue was an adequate number of personnel. A considerable portion of assaults may relate to circumstances that are amenable to intervention, and assaults may be reduced in severity or number by changes in hospital practices.

Attitude of Health Personnel↗