Search PubMed⌕ Search

Biomedical subjects

N Nand

Publications and source records attributed to N Nand.

49 records · Page 3Linked to original sources
PubMed1986

Left ventricular performance after blood transfusion in cases of chronic severe anemia. A study of systolic time intervals.

Left ventricular performance was studied by measuring systolic time intervals (STIs) in 15 adult cases of chronic severe anemia (CSA) before and after transfusion of 350 and 700 ml of whole blood at a moderately rapid rate of 5 ml/min. Cases with systemic disease and congestive heart failure were excluded. STIs before blood transfusion (BT) showed wide variations, but these were within normal limits in 80% of the cases. Following BT, left ventricular ejection time (LVET) increased significantly (p less than 0.001) without much change in the pre-ejection phase (PEP). There was no significant change in the PEP/LVET ratio after BT. It is concluded that transfusion of 700 ml of whole blood at a rate of 5 ml/min to patients with CSA is devoid of any risk, so far as myocardial contractile function is concerned.

Adolescent↗
PubMed1985

A comparative study of conventional vs rapid speed of blood transfusion in cases of chronic severe anemia.

Pulmonary capillary 'wedge' pressure (PCWP) was studied in 20 cases of chronic severe anemia before and after transfusing one unit of blood. They were divided into 2 groups of 10 age and sex matched cases. Blood was transfused at a speed of 2 ml/min in group A and 5 ml/min in group B. Pretransfusion PCWP was normal in all the cases. Following blood transfusion (BT) 'wedge' pressure increased significantly (p less than 0.001) in both the groups being 17.2% and 29.2% in group A and B respectively. The difference in the rise of PCWP between the two groups was not statistically significant (p greater than 0.05). All the cases tolerated BT very well. It is therefore, concluded that transfusion of one unit of blood at a speed of 5 ml/min is nearly as safe as when it is transfused at a rate of 2 ml/min (conventional speed) so far as the cardiopulmonary haemodynamics are concerned.

Adult↗
PubMed1985

Hemodynamic evaluation of blood transfusion in chronic severe anemia with special reference to speed of transfusion.

Left ventricular filling pressure (LVFP) as reflected by pulmonary capillary wedge pressure (PCWP) was measured in 40 adult cases of chronic severe anemia (CSA) before and after transfusion of 1 unit of whole citrated blood, using Swan-Ganz monitoring catheters. The cases were randomized into 4 groups of 10 each. Blood was transfused at a rate of 2 ml, 5 ml and 10 ml/min in groups A, B and C, respectively. In group D, blood transfusion (BT) was given at 5 ml/min but this group received, in addition, 40 mg furosemide intravenously just prior to the transfusion. Pretransfusion PCWP was normal in all the cases. Following BT the "wedge" pressure increased significantly in the first 3 groups, the rise being proportionately greater with faster transfusions (15.8, 20.9 and 32.2% in groups A, B and C, respectively). In group D, however, PCWP actually decreased by 21.7% (p less than 0.001). As far as we know, this is the first study in which a definite and significant rise in PCWP has been documented following transfusion of blood even at conventional speed (group A). The implications of such an increase in "wedge" pressure as well as the observation that it can be completely blocked by furosemide are discussed. On the basis of these observations it is recommended that intravenous furosemide should be administered routinely before any BT in cases of CSA. Such practice will also permit blood to be transfused at a comparatively faster speed, without jeopardizing patient safety.

Adolescent↗
PubMed1983

Cardiovascular complications of enteric fever.

A case of a young female having salmonella typhi infection with cardiovascular complications in the form of myocarditis and femoral artery occlusion is reported. The relevant literature on the subject is reviewed, and possible mechanisms discussed.

Adult↗
PubMed1983

Haemodynamic changes following blood transfusion in cases of chronic severe anemia: increased safety with simultaneous furosemide administration.

Left ventricular filling pressures as reflected by pulmonary capillary wedge pressure (PCWP) were measured in 20 adult subjects of chronic severe anemia before and after transfusing one unit of blood. The cases were divided into two groups of ten each. In both groups blood was transfused at a speed of 5 ml/mt; group II cases received, in addition, 40 mg furosemide intravenously just before the start of the transfusion. Pretransfusion PCWP was normal in all the cases. Following transfusion, 'wedge' pressure increased significantly (P less than 0.001) in group I but not in group II patients, in whom it actually decreased (P less than 0.001). It is concluded that prior administration of furosemide completely prevents any increase in LVFP following transfusion of one unit of blood at a moderately rapid speed, and makes such a transfusion quite safe, at any rate, so far as pulmonary haemodynamics are concerned.

Adolescent↗
PubMed1982

Left ventricular filling pressures after rapid blood transfusion in cases of chronic severe anemia.

Left ventricular filling pressure as reflected by pulmonary artery wedge pressure was measured in 15 adult cases of chronic severe anemia before and after rapid and large blood transfusion, using Swan-Ganz monitoring catheters. Pre-transfusion PAWP was normal in 80% of the cases but increased significantly after blood transfusion (P less than 0.001), reaching more than 18.0 mm Hg in 3 cases. No correlation was found between right atrial pressure and PAWP. In is concluded that administration of 2 units of blood at a rapid speed (8.92 +/ 1.73 ml/minute) in cases of CSA is not always quite safe so far as pulmonary hemodynamics are concerned and should therefore be avoided.

Adolescent↗
PubMedDate not supplied

Evaluation of left ventricular functions in chronic renal failure before and after acute hemodialysis.

Left ventricular functions were evaluated in 25 adult patients of chronic renal failure by 2-D echocardiography before and after four hours of standard hemodialysis session. Eighteen patients showed clinical evidence of fluid overload. Predialysis left ventricular end-diastolic diameter, left ventricular end-diastolic volume, left ventricular end-systolic diameter and left ventricular end-systolic volume were comparable in patients with or without fluid overload. Similarly, predialysis stroke volume and left ventricular ejection fraction were not significantly different in the two subsets. However, following hemodialysis there was a significant decrease in the left ventricular systolic and diastolic volumes and diameters in patients with fluid overload. The improvement in the left ventricular ejection fraction was of the same magnitude in the two subsets. The significant improvement in the left ventricular functions both in patients with and without fluid overload indicates that fluid overload may not be the only determinant of left ventricular functions in patients of chronic renal failure, but other factors, such as various uraemia toxins and metabolic changes might also be inhibiting the myocardial functions.

Adult↗