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Biomedical subjects

N N Zakharova

Publications and source records attributed to N N Zakharova.

At least 19 recordsLinked to original sources
PubMed1995

[The characteristics of the cognitive defect in patients with different variants of late paranoia].

Evoked cortical activity in response to acoustic stimuli (oddball paradigm) was studied in patients with different paranoid disorders. The analysis covered the N150 negative wave and positive complex P300. In patients with paranoid schizophrenia and paranoid form of involutional psychosis cortical responses to the stimuli and cortex effects were not recorded. Such cognitive deficiency is believed to be typical for schizophrenia.

Aged↗
PubMed1994

[The psychophysiological criteria for assessing the excitable type of psychopathy].

In the excitable psychopaths and persons with some psychopathic traits (Leonard's "accentuated personality") the study was made of a cognitive function of discriminating microintervals and event-related potentials to visual stimuli. A qualitative difference in the accomplishment of the cognitive task between the two groups was found. Disturbances of the cognitive function, learning deficiency and reduction of the P300 wave provide grounds for referring this ""antisocial personality disorder" to pathology of the limbic system of the brain.

Adult↗
PubMed1993

[Disorders in the mechanism of information selection in schizophrenic patients].

Two groups of schizophrenics with negative and positive syndromes were studied by registering cortical evoked potentials in response to acoustic stimuli of different meaning (odd-ball paradigm). Disfunction of selective attention is related to the impaired ability to differentiate relevant and irrelevant information. Disturbances of information selection were more pronounced in the patients with paranoid schizophrenia.

Acoustic Stimulation↗
PubMed1991

[Relation between cognitive activity of excitable psychopathic personalities and the pattern of reinforcement].

Excitable psychopathic personalities manifest qualitative and quantitative disorders of cognitive activity directly unrelated to emotional reactions. If the result of the activity is estimated by some other person with the aid of positive and negative reinforcement stimuli, deficit of the training is marked to a much greater degree than in cases where the excitable personality itself draws, on the basis of information available in the feedback stimulus, the conclusion whether its decision was right or erroneous.

Adult↗
PubMed1990

[Differences in the effect of diazepam on realized and non-realized conditioned emotional reactions].

Evoked cortical potentials in response to conditioned visual stimuli were recorded in excitable psychopathic personalities in the course of formation and reproduction of temporary relations with a realized or non-realized emotional word. Diazepam (10 mg intramuscularly) suppresses cortical reaction worked out previously with the aid of a realized emotional word and fails to produce and action if that word was non-realized. The fact of the lack of the diazepam effect on conditioned emotional reactions formed at the non-realized level should be taken into consideration in the treatment of patients with disturbances in the emotional sphere.

Adult↗
PubMed1982

[Functional changes in the central nervous system during music perception (study of positive emotions)].

Music as a factor of creating a certain emotional state, may be used for studying neurophysiological bases of human positive emotions. Investigations of conservatory students and people without special musical education have shown that music exerts complex influences on the CNS, manifested in changes of a number of neurophysiological reactions attesting changes in the flow of excitations in the cortico-thalamic and cortico-limbic circles. Listening to music is accompanied with a partial replacement of the dominating alpha-rhythm by activity in the frequency range of beta-, theta- and delta-waves and with a change of some vegetative reactions. It was possible to define some qualitative differences in the action of music on the CNS depending on the interpretation of the composition as well as the presence or absence of musical education of the listeners.

Adult↗
PubMed1979

[Effect of small doses of alcohol on emotional stress in patients with late sequelae of cranio-cerebral injuries].

An experimental study of individuals with late sequelae of closed cerebrocranial trauma, demonstrated that diverse signs of CNS activity to a different extent may be under the influence of small doses of alcohol. For instance, the sensorial process does not change significantly, which may indicate a relative independence of specific sensorial pathways (including the cortical area) from small doses of alcohol. Changes in cortical electro-activity and the threshold of the orientation reflex, the mechanisms of which are connected with the function of the brain stem reticular formation, points to an inhibitory action of alcohol on it. Against the background of alcoholic influence the socially significant emotionally negative stimula intensify emotional stress, the action of which is related to the activity of the limbic system structures and a weakening of the function of associative cortical fields. The results of this study permit to assume that different functional-structural mechanisms may lie at the basis of an emotional background (mood) and emotional stress.

Adult↗