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Biomedical subjects

N N Piatovskaia

Publications and source records attributed to N N Piatovskaia.

12 recordsLinked to original sources
PubMed1991

[Effect of emulsions of carbon perfluoride compounds on the blood plasma complement system and functional state of the rabbit brain].

Experiments were conducted in vitro on rabbits to study the effect of emulsions based on composition of carbon perfluorides (decalin perfluoride/methyl cyclohexyl piperidine perfluoride) and proxanol (P-268) on the blood complement system. It is shown that despite preservation of the composition some emulsions activate complement others fail to do this. Intravenous infusion of complement-activating emulsion in a test-dose leads to early neutropenic reaction in the peripheral blood of rabbits and intensified power of low frequency rhythms in the electrocorticogram.

Animals↗
PubMed1990

[Activation of the complement system of plasma and the changes in various parameters of homeostasis in rats after intravenous administration of emulsion of organoperfluorine compounds].

Anticomplementary activity of emulsion based on the organoperfluorine compounds (PFC) perfluorodecalin and perfluorotripropylamine (7:3) has been shown in vitro. A temporary reduction of the neutrophil number up to 25% of the initial level was recorded 5 min after intravenous plethoric administration of 1.0 ml of this emulsion to rats. A drop in the arterial pressure and blood minute volume was observed in half of the animals, 30 and 60 min later impairment of the body oxygen regimen resulting in tissue hypoxia was recorded in all the rats. It has been suggested that the disorders observed in the animals are caused by the action of varying mediators produced due to the intravascular activation of the complement by PFC.

Animals↗
PubMedDate not supplied

[Microfluorimeter for biomedical research].

A new microfluorimeter built on the basis of the fluorescence microscope scheme is described. The study object is illuminated on the reading side. The device is highly sensitive and allows small amounts of fluorescent agents to be investigated. The microfluorimeter has been used to study the absorptive activity of the gastrointestinal tract.

Animals↗