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Biomedical subjects

N N Iezuitova

Publications and source records attributed to N N Iezuitova.

At least 19 recordsLinked to original sources
PubMed2002

[Effects of thyroxine and dexamethasone on kinetic characteristics of the small intestine enzymes in rat pups following a low-protein diet in female rats during lactation].

It is shown, that the value of Km for maltase, alkaline phosphatase, aminopeptidase M and glycyl-L-leucinedipeptidase, prepared from the jejunum and ileum of 10-day rat litter in membrane and soluble forms in most cases differed but a little in control animals and the rat litter whose mothers in the period of lactation had a diet with 2.5-fold reduced content of protein, and did not change under action of injected thyroxin and dexamethasone. It may be assumed that in the given experimental conditions each of the investigated digestive hydrolases in membrane and soluble forms represents the same enzyme. In conditions of the protein insufficiency in lactating females diet and under action of exogene hormones, apparently, no significant changes occur in structure of synthesised enzymes.

Animal Feed↗
PubMed2002

[Delayed effects of protein deficiency in nutrition of the pregnant rats on development of the enzymatic system in digestive and nondigestive organs of offspring].

It has been found for the first time that protein deficit in female's nutrition during prenatal development of the offspring is accompanied by considerable changes in the activity of intestinal digestive enzymes and of the same hydrolases in the colon, liver and kidneys both in early and in late ontogenesis. It seems possible that changes of the small intestine enzyme functions and hydrolytic functions of other digestive and non-digestive organs in result of an unfavorable early "metabolic/nutritional programming" may be crucial in disorders of metabolic processes leading to development of diseases of risk in adult life.

Animals↗
PubMed2000

[Hydrolases in the large intestine in rats with various experimental pathologies].

In the colon mucous membrane, activity of a wide range of membrane and mainly intracellular enzymes was studied in the organism at different conditions. The data obtained suggest participation of digestive hydrolases in the colon not only on postdigestive processes but, in certain states of the organism, in digestive processes too.

Animals↗
PubMed1999

[Effect of protein deficiency in the female rat diet during pregnancy and lactation on the activity of the membrane and soluble forms of digestive enzymes in the offspring small intestine].

Protein deficiency in female rats diet during pregnancy and lactation resulted in deceleration of induction of sucrase both forms in the jejunum and ileum; in acceleration of induction of the maltase membrane from in the jejunum; and in suppression of the lactase membrane form in the ileum; in earlier forming of the adult-type distribution of activity of the membrane form of intestinal alkaline phosphatase and in a decrease in activity of the enzyme soluble form. The findings are corroborated by a suppression of activities of the membrane and soluble forms of the small intestine digestive enzymes in 30-day old rat pups fed with a control (adequate) ration starting 21 days after the birth.

Alkaline Phosphatase↗
PubMed1996

[The enzyme systems of the epithelial and subepithelial layers of the rat small intestine after the transposition of its sections].

At different times after the transposition of the jejunum and ileum of rats bidirectional changes in the mass and activity of digestive enzymes were observed not only in the epithelial but also in the subepithelial layers of various parts of the small intestine and in the duodenal mucosa. The greatest increase in the mucosal mass was revealed in the duodenum. The activity of membrane enzymes changed insignificantly in the epithelial and subepithelial layers. The activity of cytosolic peptidases was increased to the greatest extent in the subepithelial layers of the small intestine, especially at the early terms after surgical interventions. It is concluded, that the enzyme systems (particularly, peptidase) of the subepithelial layers of the small intestine are an integral part of the enzymatic barrier and perform an important protective function.

Animals↗
PubMed1996

[Digestive enzyme activity in growing rats consuming nitrates against a background og protein insufficiency].

The effects of sodium nitrate on the activity of digestive enzymes in mucosal and submucosal layers of the small intestine as well as in liver and kidney were studied in the growing rats maintained on either standard or protein-free diets. The enzyme systems were more sensitive in the growing rats to protein deprivation than in adult animals. However, the digestive enzymes were more resistant against nitrate intoxication in the growing rats.

Animals↗
PubMed1996

[Hydrolases of the digestive and nondigestive organs in rhesus macaque monkeys].

Distribution of activity of a wide range of hydrolases was characterised in the duodenum, ileum, jejunum, and colon, as well as in the liver, kidney and spleen in Macaca rhesus. The findings suggest presence of a complex enzyme system performing the membrane and intracellular hydrolysis of nutritional substances, in the small intestine of the primates as well as other mammals. This system, along with the hydrolases of the colon and non-digestive organs, seems to function as an enzymatic barrier.

Animals↗
PubMed1994

[Protein starvation and the trophic barrier functions of the enzymatic and transport systems of the digestive and nondigestive organs in adult and growing rats].

A reduced activity of cytosol dipeptidases was revealed both in epithelial and subepithelial layers of the small intestine against the background of protein deprivation in adult and maturing rats. The latters' enzyme systems of the small intestine and kidneys' layers proved to be particularly sensitive to protein deprivation. The disturbance of the digestive-barrier functions provides favourable conditions for penetration of foreign protein and peptide substances into the organism's inner milieu which can be dangerous for a maturing organism.

Animals↗
PubMed1992

[The enzymatic barrier of the small intestine].

The small intestine's barrier functions are reviewed. The data on mechanical (passive) and active protective systems of the organism against various antigens, toxic substances and proteins, is presented. An important role of these protective systems as an enzyme apparatus of epithelial and postepithelial layers of the small intestine's mucose, is shown.

Animals↗
PubMed1992

[The enzyme-transport characteristics of the small intestine of rats during aging].

Ageing was shown to be accompanied by changes of the activity levels of the small intestine's carbohydrases, dipeptidases, and alkaline phosphatases. The changes occurred both under normal conditions and after operations on the small intestine. In ageing, the small intestine's capacity for the homeomorphosis decreases irrespective of either increase or decrease in the functional loading. The age involution of the gastrointestinal tract is followed by disturbances not only in hydrolytic processes but in transport those as well: particularly deceleration of glucose accumulation in preparations of the rat intestine mucose. Regulatory properties of some enzymes were changed, too, in old rats.

Aging↗
PubMed1992

[The digestive enzymes in the gastrointestinal tract, kidney, liver and spleen in different functional states].

A wide range of digestive enzymes with different cellular location (membrane, intracellular, Lysosomal) was determined in gastrointestinal organs (stomach, duodenum, jejunum, ileum, colon) as well as in undigestive organs (liver, kidney, spleen) in normal conditions and in altered functional states (fasting, refeeding). High levels of peptidase activity was noted in undigestive organs and the colon as compared to that in the small intestine. Adaptive responses were (revealed not only for a number of membrane enzymes but also for intracellular ones including those in undigestive organs.

Adaptation, Physiological↗