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Biomedical subjects

N Mutsuga

Publications and source records attributed to N Mutsuga.

At least 37 records · Page 2Linked to original sources
PubMed1979

Microneurosurgery for aneurysms of the basilar artery.

The authors report microsurgical treatment in 32 cases of basilar artery aneurysms, operated on with good results in 28 cases, fair results in one, and poor results in one; there were two deaths. Twenty-nine patients (91%) were able to return to social activities. Characteristics of the surgical techniques include 1) taking a transsylvian route; 2) retracting the M1 portion of the middle cerebral artery (occasionally the C1 portion of the internal carotid) medially with tapered brain retractors; and 3) approaching the aneurysm through and between perforators arising from the posterior cerebral artery in cases of high-placed basilar bifurcation. With regard to instrument improvements, tapered brain retractors, a multipurpose head frame, and bayonet clips (Sugita design) proved very helpful.

Basilar Artery↗
PubMed1978

A newly designed multipurpose microneurosurgical head frame. Technical note.

A new multipurpose head frame has been designed for microneurosurgery. It consists of a head holder with a frame to hold self-retaining brain retractors, hand rests, instrument holders, a plate for cotton patties, and skin-flap retractors. It has been satisfactorily used in 100 operations for 1 year.

Humans↗
PubMed1977

Intracellular recording from pulsating cerebral cortex.

An instrument has been developed for recording intracellulary from cortical neurons in an exposed pulsating brain. The electrode moves with the brain pulsations maintaining the electrode within the impaled cell. Stable recordings have been obtained for up to 20 min.

Animals↗
PubMed1977

Potassium clearance and reactive gliosis in the alumina gel lesion.

Potassium accumulation or impaired potassium clearance has been hypothesized to contribute to epileptogenesis in gliotic epileptogenic foci. To test this hypothesis, potassium clearance rates following direct cortical stimulation were measured in the cortex of monkeys rendered epileptic by the injection of alumina gel into the motor area. Reactive gliosis at the sites in which potassium clearance was measured was then quantitated histologically and compared with potassium clearance rates. Dense gliosis was associated with slowed potassium clearance, although the base-line potassium level appeared no different in actively epileptogenic areas or gliotic areas compared with normal areas. Possible mechanisms and significance of slowed potassium clearance in the alumina focus are discussed.

Aluminum↗
PubMed1976

The contribution of local blood flow to the rapid clearance of potassium from the cortical extracellular space.

The transport of potassium to the blood stream following stimulation of the cortex in cats is evaluated by means of a potassium sensitive microelectrode technique. Potassium levels are measured in cortical veins, the sagittal sinus and the extracellular space during and after both pharmacological and electrical stimulation of the cortex. It is concluded that the potassium transport to the blood stream is not a significant factor in the rapid clearance of potassium from the extracellular space following stimulation.

Animals↗
PubMed1975

Temporal-lobe seizures with additional foci treated by resection.

The authors describe the use of temporal lobectomy following careful and repeated electroencephalogram (EEG) evaluation (with implanted electrodes in otherwise unresolvable cases) in the epileptic group characterized by automatisms (psychomotor seizures) with temporal epileptiform activity complicated by EEG foci in the opposite temporal lobe or by extratemporal activity. They found that this can render a significant number of patients (between 25% and 50%) either seizure-free or with significant and useful reduction in their seizure frequency. The cure and improvement rates of cases followed up after temporal resection with or without prior study with implanted electrodes were approximately equal. However, the implanted electrodes permitted surgical treatment of certain cases which would have been rejected on the basis of evidence derived from the scalp recordings alone. Of 28 of these 34 patients with persisting EEG epileptiform activity in the postoperative period, only one had such activity in a different location in a follow-up period of 6 years. No evidence of spreading epileptic activity or appearance of "mirror foci" was seen during a follow-up period averaging 8.2 years. Seizure remission up to 15 years with eventual recurrence of the original seizure type may occur following surgical therapy. Follow-up studies of surgical epileptic treatment of less than 3 to 5 years are of doubtful value.

Adolescent↗