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Biomedical subjects

N Morris

Publications and source records attributed to N Morris.

At least 73 records · Page 4Linked to original sources
PubMed1982

Valproic acid and immune thrombocytopenia.

During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may reflect the structural similarity between valproic acid and constituents of cell membranes.

Adolescent↗
PubMed1982

Management of the first 20 weeks of pregnancy.

The general practitioner is involved in many aspects of patient care during the first 20 weeks of pregnancy. The first visit involves a thorough history and examination, intelligently chosen investigations, and careful planning of antenatal care and the confinement. Even if specialist care is indicated, the family doctor may be consulted about many problems including morning sickness, abnormal bleeding and abdominal and pelvic pain.

Abortion, Spontaneous↗
PubMed1981

Birth centre confinement at the Queen Victoria Medical Centre. I. Obstetric and neonatal outcome.

A review of hte first 175 confinements at the Queen Victoria Medical Centre Birth Centre is presented. The design, structure and function of hte Birth Centre is described and the safety of the programme demonstrated. Seventy-four pregnancies (42%) accepted for Birth Centre confinement required transfer because of antepartum or intrapartum complications. There were satisfactory obstetric and neonatal outcomes in all pregnancies. The first year's experience has allowed a reassessment of the risk factors, which will permit greater use of the Birth Centre without any increases risk to mothers or babies.

Australia↗
PubMed1979

Retroperitoneal lipomatosis--report of two cases with an unusual distribution.

Two cases of retroperitoneal lipomatosis with an unusual distribution are reported. In the first case the fat was confined to the perirectal soft tissues and the sigmoid mesentery, whereas in the second case it was peripancreatic and extended into the small bowel mesentery. The lipomatous nature of these retroperitoneal masses was suggested by the lucency of the fat on the plain abdominal roentgenograms. These cases were studied prior to the availability of computed tomography, so that the diagnoses were confirmed by surgical exploration, which may have been avoided by this currently available noninvasive technique.

Adult↗
PubMed1978

Cerebral radionuclide scintigraphy in the stroke syndrome.

The cerebral scans of 365 patients with the stroke syndrome were reviewed retrospectively over a 30-month period. Positive static studies occurred in 140 patients )38%), of which 73 (52%) had an associated reduction of flow to the affected hemisphere on the dynamic study. Positive dynamic studies alone accurred in 69 patients (19%), increasing the positive yield by 50%. Dynamic studies also differentiate extracranial (carotid) occlusion from intracranial vascular occlusion, and may contribute to prognosis and management. Infarction in the middle cerebral artery territory is five times as common as infarction in any other arterial territory. An unexpected finding was the high incidence (5%) of watershed infarctions. These are more common than posterior cerebral artery strokes (4%), and anterior cerebral artery strokes (1%). When patients with vertebrobasilar and lacunar strokes, and those scanned within one week or after six weeks from the onset of symptoms are excluded, the positive yield was 54% for static studies, and 67% over all.

Basilar Artery↗
PubMed1976

Defective phagocyte adherence in acute poststreptococcal glomerulonephritis: clinical and laboratory observations.

The adherence of circulating phagocytes to glass was studied in 15 children with acute poststreptococcal glomerulonephritis and in 27 healthy adults, 21 healthy children, and 14 children with normocomplementemic renal disease. The phagocytic adherence to glass in the patients with hypocomplementemic PSGN differed significantly from that of the control groups (p=less than 0.001). There was a positive correlation of phagocyte adherence with plasma C3 but not with plasma C4, C3, properdin factor B, severity of illness, or drugs administered. In addition, the adherence defect was present in two normocomplementemic PSGN patients. The defect gradually resolved in all patients with clinical improvement: it was useful as an index of recovery. The in vitro addition of functional C3 to whole blood produced the adherence defect in normal subjects and failed to correct the defect in patients with PSGN. It was postulated that a fragment of activated complement may have blocked a membrane receptor on these phagocytes and interfered with their adherence to glass.

Adolescent↗
PubMed1976

Temporal relationship between basal body temperature nadir and luteinizing hormone surge in normal women.

Basal body temperature (BBT) as a predictor of ovulation was assessed by examining the temporal relationship between the BBT shift and the luteinizing hormone (LH) surge in individual cycles of 27 normal women. For 22 of the subjects, the LH surge occurred on the same day or within one day of the BBT nadir. For the remaining five subjects, the surge fell within 2 days after or 3 days before the nadir. Despite the BBT nadir's close temporal association with the LH surge, daily examination of BBT for the purpose of predicting the day of ovulation during a given cycle is unsatisfactory. By 48 hours following the nadir, when one could usually be certain that temperature elevation had occurred, all subjects had already exhibited the LH surge.

Adult↗