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PubMed1977

Acquired chronic candidiasis treated with transfer factor.

A patient with acquired chronic oral and vaginal candidiasis resistant to topical and parenteral therapy was found to have impaired cell mediated immunity to Candida antigen and loss of skin test response to tuberculin (Mantoux). Treatment with Candida-active transfer factor produced clinical remission lasting 1 year and restitution of in vitro and in vivo immune parameters. Relapse occurred while receiving a second lot of transfer factor from the same donor. Subsequent treatment with levamisole was associated with onset of agranulocytosis.

Adult↗

PubMedDate not supplied

Development of a non-viable particulate monitoring system for drugs manufactured in an aseptic environment.

Automated non-viable particulate monitoring systems can significantly reduce sampling costs while providing increased assurance that pharmaceutical products are free of microbial contamination. The need for consistently reliable data in the batch release process requires incorporating adequate fail-safes to detect operator error and hardware malfunction. Use of the "Life Cycle Approach" in system design and validation is also needed to provide assurance that the system will continue to meet its specifications. The author has collaborated with an instrument vendor to design, install and validate a data gathering and reporting system. Test function design is also discussed.

Asepsis↗