Search PubMed⌕ Search

Biomedical subjects

N Moore

Publications and source records attributed to N Moore.

At least 145 records · Page 8Linked to original sources
PubMed1987

Is initial sensitivity to ethanol correlated with alcohol preference in alcohol-drinking and non-drinking rats?

The initial sensitivity to ethanol was determined by hypothermia and sleeping time induced by an injection of ethanol (2.5 g/kg, intraperitoneally) in Long-Evans rats whose response to ethanol was later characterized in drinking, non-drinking and other rats. The response to a nociceptive stimulus (electric shock) in drinking rats and non-drinking rats was also studied. There was no correlation between initial sensitivity to ethanol and ethanol consumption and all rats exhibited the same behaviour towards electric shock. Ethanol elimination was not significantly different in both groups after an i.p. injection of a 2.5 g/kg dose of ethanol. These data indicate that our selected drinking and non-drinking rats differ in their ethanol intake behaviour but not in their initial sensitivity to ethanol or their sensitivity to a nociceptive stimulus. Preference for, and initial sensitivity to, ethanol are therefore not related in our rats.

Alcohol Drinking↗
PubMed1987

Carbamazepine versus lithium in mania: a double-blind study.

Thirty-four manic patients were randomly assigned to treatment with carbamazepine or lithium. Clinical response was rated over 4 weeks. Twenty-eight patients, 14 in each group, completed the full protocol. Serum levels for both drugs were within the accepted therapeutic range. The overall response to treatment was not significantly different between the two groups. Comparison of individual Clinical Global Impressions, Brief Psychiatric Rating Scale, and Beigel-Murphy Manic State Rating Scale change scores showed a more consistent level of improvement across patients in the lithium-treated group compared to a minority of good responders in the carbamazepine-treated group. The findings suggest that carbamazepine has antimanic potential in specific bipolar patients whose clinical characteristics remain to be clearly defined.

Adult↗
PubMed1987

Effects of hypoxia and cytidine (5') diphosphocholine on the concentrations of dopamine, norepinephrine and metabolites in rat hypothalamus and striatum.

Experiments were performed in order to determine whether exogenous cytidine (5') diphosphocholine (CDP-choline) opposes the effects of an acute hypobaric hypoxia on the metabolism of catecholamines in rat striatum and hypothalamus. Hypoxia decreased striatal HVA, DOPAC, 3 MT, hypothalamic norepinephrine (NE), and increased both striatal and hypothalamic dopamine (DA). CDP-choline (1000 mg X kg-1 p.o.; 1 or 3 days) was devoid of effects in normoxia, but partially reversed 3 MT, NE and DA changes, potentiated the HVA and DOPAC decrease in hypoxic rats. Our results suggest that hypoxia could impair neurotransmitter release and that treatment with CDP-choline (acute, and especially subacute administration) opposes this impairment.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1986

Complete atrio-ventricular block after furosemide.

We report a case of nonfatal complete atrio-ventricular (A-V) block after injection of 125 mg of furosemide by a central vena cava catheter. Accidents with this diuretic are very rare but this observation shows that it could induce A-V conduction disturbances. When large quantities of this diuretic must be used, we would recommend a slow injection rate to avoid such accidents.

Aged↗
PubMed1986

Dynamic characteristics of dopamine, norepinephrine and serotonin metabolism in axonal endings of the rat hypothalamus and striatum during hypoxia: a study using HPLC with electrochemical detection.

The metabolism of dopamine, norepinephrine and serotonin was studied in normoxic or hypobaric hypoxic rats, using HPLC with electrochemical detection. The changes in serotonin and its metabolite 5 hydroxy indolacetic acid (5 HIAA) levels in the hypoxic striatum and hypothalamus suggest an inhibition of 5 HIAA formation and a complex interaction between synthesis, release and uptake. Hypoxia caused a decrease of the striatal levels of homovanillic acid (HVA), dihydroxy 3-4 phenylacetic acid (DOPAC) [inhibition of tyrosine hydroxylase (TH) and monoamine oxidase (MAO)] and 3-methoxytyramine (3 MT) (inhibition of release). Striatal dopamine levels were increased, suggesting an increase in granular dopamine storage, with an impaired release. Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)].

3,4-Dihydroxyphenylacetic Acid↗
PubMed1986

Survival time in hypoxic mice: differentiation between apomorphine-induced hypothermia and antihypoxic properties.

The effects of apomorphine on survival time of mice during lethal anoxic hypoxia were studied. Apomorphine induced hypothermia and an increase in survival time. Both these effects were mediated by cerebral dopamine receptors, however with different affinity for the neuroleptics haloperidol and sulpiride. These data suggest that apomorphine's antihypoxic effect is not only mediated by the classical effect of hypothermia but also by slowing of oxydative metabolism.

Animals↗
PubMed1985

Isolation and striatal (3H) serotonin uptake: role in the voluntary intake of ethanol by rats.

Ethanol preferring rats were selected and showed a constant voluntary intake of a 12 percent ethanol solution during 14 days (about 5 g/kg body weight daily). Analysis of 3H serotonin uptake by striatal synaptosomes showed that steady state 3H serotonin synaptosomal levels were lower in alcohol preferring rats. Grouping these rats (5 per cage) reduced both voluntary intake of ethanol and synaptosomal 3H serotonin uptake. Furthermore, blocking the serotonin uptake by clomipramine 5 mg X kg-1 or 10 mg X kg-1 also reduces voluntary intake of ethanol. These data are in agreement with the hypothesis of a modulation of the voluntary intake of ethanol both by chemical and housing stimulation of striatal receptors for serotonin.

Alcohol Drinking↗